Some MDVs contribute to the de novo peroxisome #biogenesis through interactions between mitochondria and the ER, a process dependent on DRP1 and peroxisomal proteins. These vesicles enable vesicle-mediated transport and inter-organelle communication essential for maintaining neuronal homeostasis.

vesicles involved in the removal of damaged mitochondrial components, small functional #
mitochondria that support cellular energy processes, and vesicles that transport newly synthesized proteins for local organelle formation.

With multicolor #STED nanoscopy, we identified 3 structurally and functionally distinct types of #MDVs in primary neurons: