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Reposted by Gerald Denis

Mother Jones @motherjones.com · Aug 26

The DOGE-triggered brain drain has destroyed government science, endangered research, and left America fading to black.

When it comes to Trump's brain drain, “the damage is already done”

How the DOGE-triggered attack on government research left America in the dark.

www.motherjones.com

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Gerald Denis @gdenisboston.bsky.social · Aug 26

>120 million Americans are diabetic or prediabetic, yet if they develop cancer, they are not treated differently in any significant way in oncology, yet they clearly do not do as well, likely because of these diabetes-driven immune defects. Our work was funded by the National Cancer Institute.

Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids - Communications Biology

Exosomal signaling from type 2 diabetes alters tumor–immune crosstalk, driving immunosuppression and tumor aggressiveness in breast cancer organoids through expansion of dysfunctional T cells and activation of invasive programs.

www.nature.com

Gerald Denis @gdenisboston.bsky.social · Aug 26

Our patient-derived organoids are the first to preserve original immune cells from human tumors, which allowed us to study patient primary T cells with single cell RNA sequencing.

Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids - Communications Biology

Exosomal signaling from type 2 diabetes alters tumor–immune crosstalk, driving immunosuppression and tumor aggressiveness in breast cancer organoids through expansion of dysfunctional T cells and activation of invasive programs.

www.nature.com

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Gerald Denis @gdenisboston.bsky.social · Aug 26

www.nature.com/articles/s42...
Excited to announce the most recent paper from my lab.
Ennis and coauthors model the breast cancer microenvironment in obesity-driven diabetes and show that anti-tumor immunity is profoundly suppressed compared to metabolically healthy #breastcancer.

Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids - Communications Biology

Exosomal signaling from type 2 diabetes alters tumor–immune crosstalk, driving immunosuppression and tumor aggressiveness in breast cancer organoids through expansion of dysfunctional T cells and activation of invasive programs.

www.nature.com

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Gerald Denis @gdenisboston.bsky.social · Aug 7

My new interview with WGBH just posted. I talk about the deepening crisis at #NIH in #medical research funding and the devastating impact on #cancer research of #Trump administration priorities.

youtu.be/iKkum-pAoYA

Science for the Public: Save Medical Science! Guest: Gerald Denis, PhD.

YouTube video by Belmont Media Center

youtu.be

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Reposted by Gerald Denis

Anonymous @youranoncentral.bsky.social · Jul 30

Tsunami warning for most pacific coast nations; 8.8 earthquake reported in Russia. Stay informed, and stay safe out there.

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Gerald Denis @gdenisboston.bsky.social · Jul 21

Genetic risk factors affect only a few cases. Family structure and environment are far greater contributors. Data show that the risk of pediatric obesity increases 4X when one parent has obesity, but 13X when both parents have obesity. That should suggest the areas of focus, and it’s not genetics.

Reposted by Gerald Denis

Nick Walden Poublon @nwpinpdx.bsky.social · Jul 10

Cherry farmers in my district in The Dalles are leaving hundreds of tons of cherries to rot because workers are too afraid of ICE raids to come harvest.

This is what happens when cruelty becomes policy. It hurts everyone.

#orpol #immigration #agriculture

www.kptv.com/2025/07/10/c...

Cherry farmer in The Dalles says ICE raid fears costing him workforce, profits

One cherry farm in The Dalles has been forced to leave tons of fruit on the branches over the lack of workforce.

www.kptv.com

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Gerald Denis @gdenisboston.bsky.social · Jul 9

Thrilled to report new findings from our #NIH supported research on breast cancer.
Obesity/ #diabetes are common and increasing across America. We report that blood #exosomes in #obesity drive progression and metastasis of triple negative #breastcancer.

bmccancer.biomedcentral.com/articles/10....

Plasma exosomes in insulin resistant obesity exacerbate progression of triple negative breast cancer - BMC Cancer

Breast cancer, the most common cancer among women worldwide, continues to pose significant public health challenges. Among the subtypes of breast cancer, triple-negative breast cancer (TNBC) is partic...

bmccancer.biomedcentral.com

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Reposted by Gerald Denis

Chris Geidner @chrisgeidner.bsky.social · Jun 15

I missed that Jeff Bezos sold the Post to Donald Trump directly.

The Washington Post @washingtonpost.com · Jun 15

Planes roared over D.C. on Saturday, tanks rolled along the National Mall, brass bands resounded and thousands of soldiers marched past cheering crowds, as the Army put on the largest show of military might in the capital in more than three decades. wapo.st/4dYFOck

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Reposted by Gerald Denis

The Lincoln Project @lincolnproject.us · Jun 6

81 years ago, America's bravest generation stormed the beaches of Normandy in hopes of freeing Europe from the clutches of a brutal authoritarian.

Today, we face authoritarianism on our shores. We owe it to ourselves, our country, and that great generation to fight for freedom here at home.

The Boys of Pointe du Hoc

YouTube video by The Lincoln Project

www.youtube.com

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Reposted by Gerald Denis

Ferric Fang, MD @fangferric.bsky.social · May 29

Two Harvard economists forecast the impact of the administration’s proposed NIH budget cuts- stunning losses in new therapies, life expectancy, and economic output with a “social cost 16 times greater than the savings the administration is attempting to achieve."

jamanetwork.com/journals/jam...

Cutting the NIH—The $8 Trillion Health Care Catastrophe

This JAMA Forum discusses the recent budget cuts to National Institutes of Health (NIH), the effects of these cuts on scientific research and health of individuals in the US, and the prospects for cha...

jamanetwork.com

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Reposted by Gerald Denis

Congresswoman Jasmine Crockett @crockett.house.gov · May 27

NPR is suing Trump.

Why? Because he slashed their funding just for doing their job—which is political retaliation.

He’s trying to silence public media because they don’t bow down to his ego.

News flash: the First Amendment doesn’t disappear just because you don’t like the coverage, Donnie.

NPR @npr.org · May 27

BREAKING: NPR and three Colorado public radio stations are suing the Trump administration over the president's executive order seeking to ban the use of federal money for NPR and PBS.

NPR and Colorado public radio stations sue Trump White House

NPR and three Colorado public radio stations are suing the Trump administration over the president's executive order seeking to ban the use of federal money for NPR and PBS.

www.npr.org

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Reposted by Gerald Denis

Ferric Fang, MD @fangferric.bsky.social · May 23

"We condemn the US government's use of extortion to coerce independent institutions to act in accordance with the administration's preferences. . . it's punishing of researchers unrelated to the charges against their universities. . . (and) its short-sighted and senseless cuts to basic research."

Steffen Mau @steffenmau.bsky.social · May 23

Skytte prize winners speak out www.ft.com/content/939b...

Letter: Prize-winning political scientists speak out

From Francis Fukuyama and others

www.ft.com

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Reposted by Gerald Denis

Neil deGrasse Tyson @neildegrassetyson.com · May 19

If a foreign adversary snuck into our Federal budget and cut science research and education the way we’re cutting it ourselves — strategically undermining America’s long-term health, wealth, and security — we would likely consider it an act of war.

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Reposted by Gerald Denis

Congresswoman Jasmine Crockett @crockett.house.gov · May 14

Marjorie, I know the truth confuses you and facts ain’t your strong suit—so let me break it down real slow:

George Floyd didn’t die from drugs. He died because Derek Chauvin knelt on his neck for 9 minutes. That’s called murder.

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Gerald Denis @gdenisboston.bsky.social · May 10

Excited to share new #NIH funded research showing that #insulin resistance drives aggressiveness of #breastcancer.
Women with #obesity and metabolic complications have higher risk of #metastasis. Model systems show we should consider this risk in #TNBC.
#NCI

www.biorxiv.org/content/10.1...

Plasma Exosomes in Insulin Resistant Obesity Exacerbate Progression of Triple Negative Breast Cancer

Breast cancer, the most common cancer among women worldwide, continues to pose significant public health challenges. Among the subtypes of breast cancer, triple-negative breast cancer (TNBC) is partic...

www.biorxiv.org

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Reposted by Gerald Denis

Christophe Veltsos @drinfosec.bsky.social · May 9

From Twitter
"You know how they say the 3rd generation to inherit wealth squanders it? That is what we are doing with public health right now. People living with all the benefits of it are dismantling it because they think it's just natural to not have constant disease..."

OP: x.com/wonderartsy/...

You know how they say the 3rd generation to inherit wealth squanders it? That is what we are doing with public health right now. People living with all the benefits of it are dismantling it because they think it's just natural to not have constant disease and death... about to FIND OUT aren't we?

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Gerald Denis @gdenisboston.bsky.social · May 2

Considering Trump‘s cabinet picks, each of whom we see are dedicated to destruction of their own agencies, I’ve been taking bets on which one will injure and kill the largest number of Americans over time.

I’m thinking that this guy will be the sweepstakes winner. 🦠

Gerald Denis @gdenisboston.bsky.social · May 2

The reviewer is a troll and should not be trusted with future grant applications.

Gerald Denis @gdenisboston.bsky.social · May 2

This is outrageous policy.

Gerald Denis @gdenisboston.bsky.social · May 1

A placebo arm for a randomized clinical trial of measles vaccine is profoundly unethical and wrong because it will cause avoidable harm.
Such a no brainer.
We are being led by an amoral idiot.

Jennifer Nuzzo, DrPH, SM @jennifernuzzo.bsky.social · May 1

"Vaccines for new pathogens are often tested this way. But for well-researched diseases...public health experts say it makes little sense to do that and can be unethical, because the placebo group would not receive a known effective intervention."

www.washingtonpost.com/health/2025/...

RFK Jr. will require shift in how new vaccines are tested, HHS says

The potential change outlined in a statement would require all new vaccines to undergo placebo testing, sparking concerns among medical experts.

www.washingtonpost.com

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Gerald Denis @gdenisboston.bsky.social · May 1

This work is important because obesity/diabetes considerations do not inform standards of care and breast medical oncology. At the moment 120 million American adults are diabetic or prediabetic. We know that adults with breast cancer and diabetes do less well, but the mechanisms are not understood.

Reposted by Gerald Denis

💙❤️💙Mia💙❤️💙 @mommamia.bsky.social · May 1

🚨🚨🚨
This is serious.
PLEASE READ:
🚨🚨🚨
RFK Jr plans to EXPERIMENT ON OUR CHILDREN.

“…Would subject all new vaccines, including vaccines for children & vaccines for WELL RESEARCHED DISEASES like measles & polio to placebo testing…they would take a bunch of kids, divide them into two groups
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Gerald Denis @gdenisboston.bsky.social · May 1

Excited to share a revised pre-print of Christina Ennis‘s work: obesity-driven #diabetes reveals immune dysfunction and tumor aggressiveness in #breastcancer patient-derived #organoids.
We preserved primary tumor immune infiltrates for the first time.
Thanks to #NCI.
www.biorxiv.org/content/10.1...

Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids

Women with obesity-driven diabetes (T2D) are predisposed to more aggressive breast cancers, yet patient metabolic status does not fully inform current standards of care. We previously identified plasm...

www.biorxiv.org

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