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Genome Damage and Stability Centre (GDSC)

@gdsc-sussex.bsky.social

210 followers 39 following 11 posts

The GDSC is a University of Sussex ‘Centre of Excellence’ which brings together world-leading experts and innovative approaches to create a critical mass of knowledge, skills and training, to prove that a ‘challenge is only impossible until it is done’

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Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · 8d

Prof. Tim Humphrey and Dr. Rhys Morgan both gave talks at the recent "Science Café" hosted by the Sussex Cancer Fund in partnership with the Macmillan Horizon Centre. A fabulous series of short talks for anyone interested in hearing a little more about the latest developments in cancer research.

Tim Humphrey @humphreylab.bsky.social · 9d

Delighted to wave the flag for @gdsc-sussex.bsky.social
@sussexcancer.org
@sussexbcr.bsky.social
sussexcancerfund.co.uk together with Rhys Morgan at the Science Cafe, MacMillan Horizon centre today. Thanks to Rebecca Herbertson and Stephen Robinson for organizing.
@rhysmorganlab.bsky.social

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Sep 3

#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.

doi.org/10.1038/s415...

DNA2 enables growth by restricting recombination-restarted replication - Nature

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

doi.org

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Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Aug 29

#NEW_PAPER
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

Nature Communications - The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify...

rdcu.be

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Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Aug 27

#NEW_PAPER

In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).

rdcu.be/eCGxF

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

Nature Communications - Centromeres play an essential function in faithful chromosome segregation. Here, the authors demonstrate the mechanism by which human cells dynamically modulate the activity...

rdcu.be

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Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Jul 21

Sussex is the host for this year's South West Structural Biology Consortium meeting [we snuck in... !]. Looking forward to hearing talks from Universities of Bath, Bristol, Cardiff, Exeter, Portsmouth, Southampton and of course, Sussex!

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Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Jul 18

Great post-doctoral opportunity in the laboratory of Dr Jasmeen Oberoi — who has just joined us as a team leader in the GDSC.

Jasmeen Oberoi @jasmeenoberoi.bsky.social · Jul 17

📢 New Postdoc opportunity

🧬🧪🩸 Excited to share an MRC funded Research Fellow position is available in my lab @gdsc-sussex.bsky.social to investigate novel approaches to disrupt the function of fusion kinases and their regulation by the HSP90 molecular chaperone system in leukaemia.

Research Fellow in Cancer Research at University of Sussex

An academic position as a Research Fellow in Cancer Research is being advertised on jobs.ac.uk. Click now to find more details and explore additional academic job opportunities.

www.jobs.ac.uk

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Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Jun 24

Dr. Luke Yates, along with Prof. Zhang and Prof. Burgers, summarise our current mechanistic understanding of the DNA damage checkpoint; inc. structural studies of ATM and ATR and how these work together to prevent cancer.
doi.org/10.1146/annu...
@layates.bsky.social @crick.ac.uk @washu.bsky.social

DNA Damage and Replication Stress Checkpoints | Annual Reviews

DNA damage checkpoints are key regulatory signaling cascades that arrest cell cycle progression upon DNA damage or upon DNA replication stalling and allow time for repair or correction. Failure to eli...

doi.org

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Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Jun 23

Prof. Evi Soutoglou describing what happens when DNA breaks, and when to cut, and when not to — on Brighton seafront, as part of Soapbox Science 2025 — a public outreach platform that promote women and non-binary scientists and the science that they carry out. ‪@soapboxscience.bsky.social‬

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Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · May 23

We are pleased to annouce that a 3.5-year PhD position is available in the GDSC, for a project jointly supervised by Prof. Hochegger and Dr. Oliver. For additional details, inc. candidate eligibility, and how to apply:
www.sussex.ac.uk/study/fees-f...

Life Sciences PhD Genome Stability - Understanding and Targeting Cell Cycle Control in Cancer : University of Sussex

www.sussex.ac.uk

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Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Feb 28

Many congratulations to Dr. Will Foster on succesfully defending his PhD thesis on Greatwall Kinase (GWL); co-supervissed by Tony Oliver and Helfrid Hochegger.

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Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Dec 6

The Genome Damage and Stability Centre at the University of Sussex has now joined BlueSky! Follow us here, for news, views and publications.

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