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Jan Gebauer @gebauer.bsky.social · Jul 7

First full day of the #GRC #Collagen, obviously can't share anything, but there were already amazing talks!

Photo into the lecture hall of for the GRC Collagen

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Jan Gebauer @gebauer.bsky.social · Jun 9

This sounds really interesting! Eager to test it with some structures we have lying around. 👍

Gabriele Corso @gcorso.bsky.social · Jun 6

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

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Jan Gebauer @gebauer.bsky.social · May 12

Okay, it's officially summer in Cologne, when I have to move our CryoEM machine from my office to an air conditioned room... ☀️(In Winter I am using it's heat for saving a little on heaters)

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Reposted by Jan Gebauer

Richard M. Carpiano, PhD, MPH @rmcarpiano.medsky.social · Apr 16

Do we really age in bursts like that recent study suggests? @drjenndowd.bsky.social yet again provides a terrific overview and explainer of that study.
🛟🧪 medsky 😷demography sociology

Are we really aging in bursts?

If you are nearing 44 or 60, don't panic.

jenndowd.substack.com

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Jan Gebauer @gebauer.bsky.social · Apr 16

Thanks for this! The study was all over the news in Germany, but somehow I never cared to check. As a scientist myself I really should have 🙄 Overselling scientific findings is really a problem in our days - it decreases trust in the scientific process...

Jan Gebauer @gebauer.bsky.social · Apr 11

Und ich dachte es sei ein Witz... 😂 Olli glaube ich auch, oder zumindest hat er so getan...

Jan Gebauer @gebauer.bsky.social · Apr 8

There is an #science feed and #ML in structural biology feed, but is there an protein #crystallography feed? And if not would we need one 🤔

Jan Gebauer @gebauer.bsky.social · Apr 8

Only have some slides to explain protein domains and the importance to predict those to a public audience. Not sure if those help... 🤷‍♂️

Jan Gebauer @gebauer.bsky.social · Apr 8

Full ack... Sadly the AI proponents often do not share our caution 😉

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Jan Gebauer @gebauer.bsky.social · Apr 7

I see your point, but I've heard this argument to often. "AF is different? - maybe just an important different confomer!" I do agree that crystal artefact exists and maybe this one deviation is upsold a little bit in the article, but in principle it's important to strengthen experimental strubio.

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Jan Gebauer @gebauer.bsky.social · Apr 6

Is Folding@Home still a thing? I have the impression neuronal network based methods have outpaced the energy based prediction software so far....or did they change the basis for the client? 🤔

Jan Gebauer @gebauer.bsky.social · Apr 4

Not so fond of the war theme, but I agree with the message👍. I see so many projects just doing fancy -omics, trying to solve mechanisms - but sometimes you just have to get your hands dirty and purify that f*** protein.

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Jan Gebauer @gebauer.bsky.social · Apr 2

room for improvement - it is an essential part of the scientific progress... So, is this just me?

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Jan Gebauer @gebauer.bsky.social · Apr 2

Don't get me wrong, the study seems legit and I am eager to dig into it. Although every bit of focus on collagens research is great. But I don't like this "new" trend on reporting on practically unpublished results. I think we have a peer-review system for a reason and while there might be (2/n)

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Jan Gebauer @gebauer.bsky.social · Apr 2

I am a structural biologist working with collagens, so naturally I am very interested. I only had time to skim over the paper, but I have to admit I currently fail to see why this is _major_ news. Especially, as it is not yet peer-reviewed. I frankly have more questions than answers (1/n)

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Jan Gebauer @gebauer.bsky.social · Mar 29

I have the feeling that we lived in the golden age of medicine, already before AF. Knockouts mice, crispr/cas, mRNA vacs.These are all tremendous developments - independent of AF. Don't get me wrong: I am a structural biologist and use AF every day. It's great, but medicine was great already before

Reposted by Jan Gebauer

DGMB @matrixbiologie.bsky.social · Mar 28

Congratulations to this year’s winner of the Young Investigator Award: Kristina Bubb from Cologne! @nystromlab.bsky.social

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Jan Gebauer @gebauer.bsky.social · Mar 12

Thank you 🙏

Jan Gebauer @gebauer.bsky.social · Mar 10

Thanks! Finally I found it... 🥰 Somehow, expected it would be coot-1 or something along that line...

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Jan Gebauer @gebauer.bsky.social · Mar 10

Thanks 👍

Jan Gebauer @gebauer.bsky.social · Mar 9

Hi, could you please add me to the science feed? I am a structural biologist. You'll find the University facility I supervise here px.uni-koeln.de and papers on my own page Gebauer.koeln thanks a lot!

RG Baumann

px.uni-koeln.de

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Jan Gebauer @gebauer.bsky.social · Mar 9

I also thought about protein structures, but there is no left-handed alpha helix 🤔 but maybe that's the point? On the other hand the zigzag is not disordered... Frankly no idea... From which science area is it?

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Jan Gebauer @gebauer.bsky.social · Mar 9

And still, it's relatively often wrong - at least for protein complexes 😉

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Reposted by Jan Gebauer

Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · Mar 8

I added support for Boltz1 so we can calculate ipSAE and other scores for pairwise protein-protein interactions on AF2, AF3, and Boltz1 models. Will add nucleic acids eventually. github.com/DunbrackLab/...

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Jan Gebauer @gebauer.bsky.social · Mar 9

This sounds interesting and maybe exactly what I need. Plan to di some screening with #AF3 and a proper implementation ofna scoring function was still missing 👍 thanks!

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