Lightnews — Scholar-powered news

DNA Bendability Regulates Transcription Factor Binding to Nucleosomes (PIONEAR-seq)

1 3 5

GenomeTDCC @genometdcc.org · 21d

New video! Discover how transcription factors find their way through tightly packed DNA. 🧪🧬💻👩‍🔬

www.youtube.com/watch?v=gOta...

Luca Mariani & Martha Bulyk introduce PIONEAR-seq, revealing how DNA flexibility shapes gene regulation.

Recently published in @natsmb.nature.com

Non-profits wade in where for-profit life science investment fears to tread - Nature Biotechnology

2 3

GenomeTDCC @genometdcc.org · Sep 8

SO many great talks from leading scientists who develop and use various genomic technologies. 🧪🧬💻👩‍🔬

Genome architecture, RNA regulation + modification identification, nanopores, DNA writing, statistics, sequencing!

It's all there on the GenomeTDCC YouTube channel!
www.youtube.com/playlist?lis...

9

Reposted by GenomeTDCC

Nature Biotechnology @natbiotech.nature.com · Sep 5

Non-profits wade in where for-profit life science investment fears to tread nature.com/articles/s41...
rdcu.be/eyzXy

For decades, and in the exceptional instance of the Institut Pasteur for over a century, non-profit organizations have augmented R&D to advance scientific understanding and develop affordable and ...

nature.com

7 7

GenomeTDCC @genometdcc.org · Sep 3

Don't miss hearing from Shubham Khetan and Martha Bulyk in this publication highlight video where they discuss their work developing PADIT-seq. 🧪
youtu.be/45hdZ6R9fX4

PADIT-seq: Protein affinity to DNA by in vitro transcription and RNA sequencing

PADIT-seq: Protein affinity to DNA by in vitro transcription and RNA sequencing

2 2

GenomeTDCC @genometdcc.org · Sep 3

Martha Bulyk & Shubham Khetan just dropped a @nature.com paper redefining how we think about transcription factor binding, noncoding variants, and disease.
PADIT-seq, reveals that multiple overlapping binding sites drive TF occupancy and gene expression 🧪🧬💻👩‍🔬

Highlight 📽️https://youtu.be/45hdZ6R9fX4

Technology Development for Genome Analysis - Rob Mitra, PhD

2 5

GenomeTDCC @genometdcc.org · Aug 29

🧪

Scripps Research @scripps.edu · Aug 29

Join us Oct. 2, 2025, for this year's Biotech Innovation Summit—featuring keynotes, fireside chats and one-on-one networking with investigators pioneering early-stage breakthroughs.

Spots are limited! Register now: ow.ly/rcGM50WN8Uc or contact [email protected] for more info.

1 2

GenomeTDCC @genometdcc.org · Aug 27

What if doing something poorly could lead to something great?
Rob Mitra, @washugenetics.bsky.social, dives into the evolution of genome tech, short-read sequencing, and how his lab is fighting rising drug costs with innovation. 🧪🧬💻 #STS

📺 Watch the keynote: youtu.be/C8U5WDA9ri4
#genomics #Biotech

Sequencing a DNA analog composed of artificial bases

1 5

GenomeTDCC @genometdcc.org · Aug 25

What if DNA didn’t use ACGT, but had PZSB instead? UW and FfAME researchers describe how they were able to sequence a synthetic DNA molecule made from 4 artificial bases in @natcomms.nature.com 🧪🧬🖥️

Check out the publication highlight on “ALIEN DNA” 👇
www.youtube.com/watch?v=S6tE...

Peeking Behind the Curtain: Technologies to Unveil RNA Modification Landscape - Kristin Koutmou, PhD

2

GenomeTDCC @genometdcc.org · Aug 22

RNA isn’t just a messenger. It’s a modified masterpiece! 🧪
Over 10,000 sites in mRNA are chemically tagged, and we’re only beginning to understand why.

Kristin Koutmou @umich.edu explores the tools that reveal this hidden layer of gene regulation. Must-watch! 🎥👇
www.youtube.com/watch?v=s5Bt...
👩‍🔬🧬🖥️

Nanopore Sequencing Beyond ACGT - Andrew Laszlo, PhD

1 1 4

GenomeTDCC @genometdcc.org · Aug 21

DNA beyond ACGT? But how do you sequence? 🧬 🖥️
youtu.be/GN6_Hc9tYow
Andrew Laszlo explains how #nanopore sequencing reads modified and synthetic bases like Z, P, B, and S by measuring ion current shifts instead of chemical pairing.

This technology could reshape synthetic biology and epigenetics. 🧪

Decoding the Centra Dogma with Single Molecule Sequencing - Winston Timp, Ph.D.

2

GenomeTDCC @genometdcc.org · Aug 20

Winston Timp @timp0.bsky.social explains how single-molecule seq is transforming our understanding of gene regulation and epigenetic complexity 🧪🖥️🧬

www.youtube.com/watch?v=fj1_...

Direct detection of 5mC and 5hmC, supports cell-type deconvolution, and reveals tissue-specific regulatory features

From Typewriters to Code Editors: The History and Future of DNA Writing Tools - Sasha Levy, PhD

1

GenomeTDCC @genometdcc.org · Aug 13

DNA has become programmable. 🧬🖥️
Sasha Levy (BacStitch DNA) discusses how #DNA engineering has evolved from basic cut-and-paste to programmable systems. Learn how enzymatic synthesis and in vivo assembly are shaping the future of synthetic biology 🧪 #STS
youtu.be/kSAm-2FbNus

Making Genomics More Reliable with Statistics - Jingyi Jessica Li, PhD

1 2

GenomeTDCC @genometdcc.org · Aug 8

Jingyi Jessica Li @jsb-ucla.bsky.social (@fredhutch.bsky.social) (formerly @ UCLA) explains how statistics can make genomics more reliable
From RNAseq to single-cell data, she shows how permutation testing reveals flaws in popular methods and can help make better decisions 🧪🖥️🧬👩‍🔬
youtu.be/t2pxOsJ9mgE

Sequencing a DNA analog composed of artificial bases - Nature Communications

4

GenomeTDCC @genometdcc.org · Aug 7

Not that kind of Alien!👽
De novo #nanopore sequencing of ALIEN (ALternative Isoinformational ENgineered) #DNA. Direct, label-free, single-molecule sequencing. @natcomms.nature.com
www.nature.com/articles/s41...

Funded in part by an NHGRI Opportunity Fund (genometdcc.org/opportunity-...)
🧪🧬🖥️ #STS

The ability to sequence oligonucleotides which consist entirely of artificial bases will facilitate their ongoing development and use. Here authors demonstrate de novo nanopore sequencing of DNA oligo...

www.nature.com

1 1

GenomeTDCC @genometdcc.org · Aug 5

RNA is never naked 🧪🖥️🧬
Gene Yeo @ucsandiego.bsky.social reveals how RNA-binding proteins (RBPs) shape gene expression, drive disease, and can unlock new therapies. From splicing to synthetic RBPs, this talk is packed with insights
youtu.be/AnhbGp-pA-w
#RNA #AcademicSky
@sanfordstemcell.bsky.social

RNAs are not naked - Gene Yeo, PhD, MBA

1 9

GenomeTDCC @genometdcc.org · Aug 4

📢Job Opening! 🧪🖥️🧬👩‍🔬
Ready to hire qualified candidates to map #RNA modifications in human transcriptomes using #nanopore direct sequencing.
Dr. Ya-Ming Hou at Thomas Jefferson University
houlaboratory.com/research

#HigherEd #EDUSky #AcademicSky #STS

2 5

GenomeTDCC @genometdcc.org · Aug 1

Happy #RNADay!
What happens to RNA after transcription?
@stirlingchurchman.bsky.social tracks RNA flow through the cell, revealing key insights into gene regulation, nuclear degradation & RNA kinetics. A fascinating look into #RNA biology! 🧪🧬🖥️👩‍🔬
youtu.be/XAKMASk_fc4

The Many Lives of mRNA

University labs help power America's biotech innovation ecosystem

2 7

GenomeTDCC @genometdcc.org · Jul 31

🧪👩‍🔬

Dr. Jean Fan @jef.works · Jul 31

In this interview, I explain how university research, when funded by independent #NIH #NSF federal grants, brings oversight to biotech to fuel innovation while keeping science transparent, reliable, and in service of the public good: hub.jhu.edu/2025/07/30/j...

#ResearchMatters

Hopkins researcher Jean Fan and her team create open-source tools that help bridge the gap between academic discoveries and life-saving treatments. Cuts to federal funding threaten to break this criti...

hub.jhu.edu

3

GenomeTDCC @genometdcc.org · Jul 30

How does 6ft of #DNA fit inside a cell only 10 microns wide?

@sstevenwang.bsky.social provides a brief history of contemporary 3D #genomics technologies. Learn how spatial organization of DNA plays a vital role in gene regulation, development, and disease. 🧬🖥️🧪 #STS
www.youtube.com/watch?v=gXCO...

A Brief History of Contemporary 3D Genomics Technologies