Thank you @fattoquotidiano.bsky.social for covering our @nature.com article.

www.ilfattoquotidiano.it/2025/08/21/m...

Reserach article: doi.org/10.1038/s415...

The STING of death continues!
Thanks to @natrevrheum.nature.com (doi.org/10.1038/s415... & rdcu.be/eJjhl ) for highlighting our recent @nature.com paper (doi.org/10.1038/s415...) cell death inhibition as a therapy for autoinflammatory diseases (SAVI)
#immunity #celldeath #rheumatology #vasculitis

Just found this post from
Nature on the AAP of our paper. Soon the official print version…

Thank you 🙏

Thank you 🙏

Thank you 🙏

This work was funded by BCCologne, SFB1530, SFB1399 and the CANTAR network and supported by the SFB_1403

A special thanks to Henning Walczak for all his support.
Thanks also to all other collaborators: Trifunovic lab, Federica Locci, Martin Peifer , Fabrizio De Bendetti, Giusi Prencipe and Antonella Insalaco.

Our work shows that STING triggers ZBP1-mediated necroptosis independently of TNFR1 and FADD. Inhibiting necroptosis prevents STING-associated vasculopathy with onset in infancy (SAVI), paving the way for cell death inhibition as a therapeutic strategy for STING-driven inflammatory diseases

I am beyond excited and incredibly proud to share that our work is now out in @nature.com This discovery was made possible thanks to the first author Kostas kelepouras, my fantastic lab , and the unique research environment here in Cologne in collaboration with the Hospital bambino Gesu in Rome.

In my lab we are interested in understanding how aberrant activation of cell death & inflammation drive loss of tissue homeostasis and how genetic instability contributes to the loss of this balance. If you are interested in discussing this topic, joining our lab or collaborate please let me know.

Just back from the TNF CONFERENCE in China, Full of ideas and inspiration. Thank you to the organisers for such an amazing conference and line up of fantastic speakers #tnf #celldeath #innateimmunity