To reroute a cytokine’s signaling, Abhiraman et al. generated soluble adaptors comprising units that bind to two sites on a cytokine linked to units that bind to and compel dimerization/activation [...] bit.ly/4l0nd2G  @stanfordmedicine.bsky.social  @gitaabhiraman.bsky.social

What is the impact of microplastics on human health? The latest episode of Beyond Journal Club, a collaboration between @coreimpodcast.bsky.social and NEJM Group, takes a deep dive into the APAChE study on microplastics and cardiovascular disease. 🎧 Listen here: nej.md/4igpJQy

#MedSky

Many thanks to Chris Garcia, Karsten Householder, @graysonrodriguez.bsky.social, Caleb Glassman, Robert Saxton, our collaborators @retickerflynn.bsky.social, Cort Breuer, Venu Pillarisetty at UW, and several others in the Garcia lab who contributed to this work!

Conversely, we show that cytokine adaptors can convert inflammatory cytokines into immunosuppressive signals. We show conversion of IL-23 or IL-17 into immunosuppressive IL-10 receptor agonists, with potential applications in autoimmune disease.

As proof of concept, we design cytokine adaptors that convert TGF-b or IL-10 into IL-2 receptor agonists to reverse T cell suppression, with potential applications in cancer therapy.

Excited to share this work from the Garcia Lab out today in @naturecomms.bsky.social! We engineer "cytokine adaptors", molecular immune switches that simultaneously block a target cytokine while inducing local activation of alternative cytokine receptors. rdcu.be/ec7GS

Conversely, we show that cytokine adaptors can convert inflammatory cytokines into immunosuppressive signals. We show conversion of IL-23 or IL-17 into immunosuppressive IL-10 receptor agonists, with potential applications in autoimmune disease.

As proof of concept, we design cytokine adaptors that convert TGF-b or IL-10 into IL-2 receptor agonists to reverse T cell suppression, with potential applications in cancer therapy.

Applications are open for Gates Grand Challenges - funding for projects spanning antibiotic discovery, menstrual bleeding, HIV/TB diagnosis, women’s health, and preeclampsia. Feel free to share. DM me for the email/links.

A crowd-sourced list of changes to grad school admissions and academic hiring: docs.google.com/spreadsheets...