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A new Double Take video reviews evidence-based recommendations on measles prevention and management and explores commonly asked questions about the measles virus and infection. Watch on YouTube: youtu.be/PI6M680p9i0
StepUp trial: The addition of combined oral and topical antimicrobial therapy for male partners to treatment of women for bacterial vaginosis resulted in a lower rate of recurrence within 12 weeks than treatment of the woman alone. Download the 15 Notable Articles of 2025: nej.md/49td1Lq
January 9, 2026 at 7:13 PM
StepUp trial: The addition of combined oral and topical antimicrobial therapy for male partners to treatment of women for bacterial vaginosis resulted in a lower rate of recurrence within 12 weeks than treatment of the woman alone. Download the 15 Notable Articles of 2025: nej.md/49td1Lq
VESALIUS-CV trial: Lowering LDL cholesterol levels with evolocumab reduces the risk of cardiovascular events in patients with a previous MI or stroke, but the effect in patients without a previous MI or stroke is unknown. Research is summarized in a new Quick Take video. nej.md/4jwRuGa
January 9, 2026 at 5:03 PM
VESALIUS-CV trial: Lowering LDL cholesterol levels with evolocumab reduces the risk of cardiovascular events in patients with a previous MI or stroke, but the effect in patients without a previous MI or stroke is unknown. Research is summarized in a new Quick Take video. nej.md/4jwRuGa
Serogroup switching away from serogroup Y has been identified in the major ciprofloxacin-resistant 𝘕𝘦𝘪𝘴𝘴𝘦𝘳𝘪𝘢 𝘮𝘦𝘯𝘪𝘯𝘨𝘪𝘵𝘪𝘥𝘪𝘴 strain, which may impede identification of ciprofloxacin-resistant cases of 𝘕. 𝘮𝘦𝘯𝘪𝘯𝘨𝘪𝘵𝘪𝘥𝘪𝘴 infection. Learn more: nej.md/3YoBs7B
January 9, 2026 at 2:29 PM
Serogroup switching away from serogroup Y has been identified in the major ciprofloxacin-resistant 𝘕𝘦𝘪𝘴𝘴𝘦𝘳𝘪𝘢 𝘮𝘦𝘯𝘪𝘯𝘨𝘪𝘵𝘪𝘥𝘪𝘴 strain, which may impede identification of ciprofloxacin-resistant cases of 𝘕. 𝘮𝘦𝘯𝘪𝘯𝘨𝘪𝘵𝘪𝘥𝘪𝘴 infection. Learn more: nej.md/3YoBs7B
Case Record of the Massachusetts General Hospital: A 50-year-old woman was admitted to the hospital because of fever and abdominal pain after visiting rural Brazil. Shock and disseminated intravascular coagulation developed. A diagnosis was made. Full case details: nej.md/3L2HIyT
#MedSky
#MedSky
January 8, 2026 at 8:02 PM
Case Record of the Massachusetts General Hospital: A 50-year-old woman was admitted to the hospital because of fever and abdominal pain after visiting rural Brazil. Shock and disseminated intravascular coagulation developed. A diagnosis was made. Full case details: nej.md/3L2HIyT
#MedSky
#MedSky
The 2025 edition of our annual Notable Articles collection, selected by NEJM editors, showcases the most significant contributions to clinical medicine and patient care. Download your free copy of this exclusive collection: nej.md/49td1Lq
January 8, 2026 at 4:08 PM
The 2025 edition of our annual Notable Articles collection, selected by NEJM editors, showcases the most significant contributions to clinical medicine and patient care. Download your free copy of this exclusive collection: nej.md/49td1Lq
New in the January 8, 2026, issue of NEJM:
Evolocumab in Patients without Previous MI or Stroke (VESALIUS-CV trial) nej.md/4oWrIN6
Fish Oil, Cardiovascular Events, and Hemodialysis (PISCES trial) nej.md/49zWuqo
#MedSky
Evolocumab in Patients without Previous MI or Stroke (VESALIUS-CV trial) nej.md/4oWrIN6
Fish Oil, Cardiovascular Events, and Hemodialysis (PISCES trial) nej.md/49zWuqo
#MedSky
January 8, 2026 at 2:03 PM
New in the January 8, 2026, issue of NEJM:
Evolocumab in Patients without Previous MI or Stroke (VESALIUS-CV trial) nej.md/4oWrIN6
Fish Oil, Cardiovascular Events, and Hemodialysis (PISCES trial) nej.md/49zWuqo
#MedSky
Evolocumab in Patients without Previous MI or Stroke (VESALIUS-CV trial) nej.md/4oWrIN6
Fish Oil, Cardiovascular Events, and Hemodialysis (PISCES trial) nej.md/49zWuqo
#MedSky
A 5-week-old boy was brought to the hospital with a painful scalp lump that had been present since birth. On examination, there was a tense, nonpulsatile round mass on the occiput surrounded by a ring of dark, coarse hair. Read the full case details: nej.md/3N4jkgV
#MedSky #NeuroSky #PedSky
#MedSky #NeuroSky #PedSky
January 7, 2026 at 11:00 PM
A 5-week-old boy was brought to the hospital with a painful scalp lump that had been present since birth. On examination, there was a tense, nonpulsatile round mass on the occiput surrounded by a ring of dark, coarse hair. Read the full case details: nej.md/3N4jkgV
#MedSky #NeuroSky #PedSky
#MedSky #NeuroSky #PedSky
Functional dyspepsia is a common, heterogeneous syndrome that is linked to microinflammation and overlaps with other GI disorders. Management relies on symptom-directed medications, nutrition, and psychological support. Learn more: nej.md/4aOcRjV
#MedSky #GastroSky
#MedSky #GastroSky
January 7, 2026 at 10:10 PM
Functional dyspepsia is a common, heterogeneous syndrome that is linked to microinflammation and overlaps with other GI disorders. Management relies on symptom-directed medications, nutrition, and psychological support. Learn more: nej.md/4aOcRjV
#MedSky #GastroSky
#MedSky #GastroSky
An 80-year-old man presented with a 4-day history of a rash on his abdomen. Physical examination was notable for periumbilical erythema and a small gray protrusion in the umbilicus. Read the full case details: nej.md/4pYF5NO
@i-med.ac.at #MedSky #DermSky
@i-med.ac.at #MedSky #DermSky
January 7, 2026 at 8:23 PM
An 80-year-old man presented with a 4-day history of a rash on his abdomen. Physical examination was notable for periumbilical erythema and a small gray protrusion in the umbilicus. Read the full case details: nej.md/4pYF5NO
@i-med.ac.at #MedSky #DermSky
@i-med.ac.at #MedSky #DermSky
A 50-year-old woman was admitted to the hospital because of fever and abdominal pain after visiting rural Brazil. Shock and disseminated intravascular coagulation developed. What is the most likely diagnosis?
Challenge closing soon... Cast your vote now! nej.md/3Yfizns
#MedSky
Challenge closing soon... Cast your vote now! nej.md/3Yfizns
#MedSky
January 6, 2026 at 11:24 PM
A 50-year-old woman was admitted to the hospital because of fever and abdominal pain after visiting rural Brazil. Shock and disseminated intravascular coagulation developed. What is the most likely diagnosis?
Challenge closing soon... Cast your vote now! nej.md/3Yfizns
#MedSky
Challenge closing soon... Cast your vote now! nej.md/3Yfizns
#MedSky
The authors of a new review summarize recent advances in the management and diagnosis of cardiogenic shock, including staging and therapies, and describe needs that warrant further research. Read the full review: nej.md/49ohKyV
#MedSky #CardioSky
#MedSky #CardioSky
January 6, 2026 at 8:03 PM
The authors of a new review summarize recent advances in the management and diagnosis of cardiogenic shock, including staging and therapies, and describe needs that warrant further research. Read the full review: nej.md/49ohKyV
#MedSky #CardioSky
#MedSky #CardioSky
A new Case Study in NEJM Catalyst Innovations in Care Delivery reports the results of a multiyear study of efforts to increase engagement with eligible patients through documented PrEP discussion in the primary care. Full study results: nej.md/4jjSYDL
Explore the full issue: nej.md/4j0CAHN
Explore the full issue: nej.md/4j0CAHN
January 6, 2026 at 5:06 PM
A new Case Study in NEJM Catalyst Innovations in Care Delivery reports the results of a multiyear study of efforts to increase engagement with eligible patients through documented PrEP discussion in the primary care. Full study results: nej.md/4jjSYDL
Explore the full issue: nej.md/4j0CAHN
Explore the full issue: nej.md/4j0CAHN
A 6-month-old boy was referred to a pediatric neurology clinic in Brazil for evaluation of developmental delay. CT of the head at 1 month of age had shown lissencephaly and intracranial calcifications. Read the full case details: nej.md/4qeRoVC
@ucsandiego.bsky.social #MedSky
@ucsandiego.bsky.social #MedSky
January 6, 2026 at 2:03 PM
A 6-month-old boy was referred to a pediatric neurology clinic in Brazil for evaluation of developmental delay. CT of the head at 1 month of age had shown lissencephaly and intracranial calcifications. Read the full case details: nej.md/4qeRoVC
@ucsandiego.bsky.social #MedSky
@ucsandiego.bsky.social #MedSky
Three must-read articles that made news in December:
1️⃣ Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia nej.md/48wiyQL
𝗡𝗼𝘁𝗮𝗯𝗹𝗲 𝗵𝗲𝗮𝗱𝗹𝗶𝗻𝗲:
Pioneering new treatment reverses incurable blood cancer in some patients (BBC) nej.md/497Tgdp
1️⃣ Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia nej.md/48wiyQL
𝗡𝗼𝘁𝗮𝗯𝗹𝗲 𝗵𝗲𝗮𝗱𝗹𝗶𝗻𝗲:
Pioneering new treatment reverses incurable blood cancer in some patients (BBC) nej.md/497Tgdp
Blood cancer therapy reverses incurable leukaemia in some patients
Seven out of 11 patients with incurable cancer who had the treatment appear to be cancer-free.
nej.md
January 5, 2026 at 10:45 PM
Three must-read articles that made news in December:
1️⃣ Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia nej.md/48wiyQL
𝗡𝗼𝘁𝗮𝗯𝗹𝗲 𝗵𝗲𝗮𝗱𝗹𝗶𝗻𝗲:
Pioneering new treatment reverses incurable blood cancer in some patients (BBC) nej.md/497Tgdp
1️⃣ Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia nej.md/48wiyQL
𝗡𝗼𝘁𝗮𝗯𝗹𝗲 𝗵𝗲𝗮𝗱𝗹𝗶𝗻𝗲:
Pioneering new treatment reverses incurable blood cancer in some patients (BBC) nej.md/497Tgdp
Cardiogenic shock is defined as a cardiac disorder that results in both clinical and biochemical evidence of sustained tissue hypoperfusion. Learn more about the management and diagnosis of cardiogenic shock in a new review: nej.md/49ohKyV
#MedSky #CardioSky
#MedSky #CardioSky
January 5, 2026 at 8:02 PM
Cardiogenic shock is defined as a cardiac disorder that results in both clinical and biochemical evidence of sustained tissue hypoperfusion. Learn more about the management and diagnosis of cardiogenic shock in a new review: nej.md/49ohKyV
#MedSky #CardioSky
#MedSky #CardioSky
A 𝐦𝐚𝐬𝐭 𝐜𝐞𝐥𝐥 is a tissue-resident hematopoietic effector cell that resides in vascularized tissues, with greatest densities in mucosal and cutaneous barrier tissues. Full definition of this NEJM Illustrated Glossary term: nej.md/4qnpC9J
#MedSky #PedSky #Immunology
#MedSky #PedSky #Immunology
January 5, 2026 at 5:09 PM
A 𝐦𝐚𝐬𝐭 𝐜𝐞𝐥𝐥 is a tissue-resident hematopoietic effector cell that resides in vascularized tissues, with greatest densities in mucosal and cutaneous barrier tissues. Full definition of this NEJM Illustrated Glossary term: nej.md/4qnpC9J
#MedSky #PedSky #Immunology
#MedSky #PedSky #Immunology
In an update of the BArT study, direct-acting antivirals led to durable responses in HCV-associated indolent B-cell lymphomas, with 6-year progression-free survival of 66% and no relapses after a complete response. Read the full update: nej.md/48OP2qS
#MedSky #Hematology #GastroSky
#MedSky #Hematology #GastroSky
January 4, 2026 at 8:02 PM
In an update of the BArT study, direct-acting antivirals led to durable responses in HCV-associated indolent B-cell lymphomas, with 6-year progression-free survival of 66% and no relapses after a complete response. Read the full update: nej.md/48OP2qS
#MedSky #Hematology #GastroSky
#MedSky #Hematology #GastroSky
A 31-year-old woman presented to the emergency department with a 10-day history of fever, sinus pressure, cough, nausea, and vomiting. Figure 2 from the case shows imaging studies from the skull base to mid-thigh. Read the full case details: nej.md/4sbcTbS
January 4, 2026 at 2:01 PM
A 31-year-old woman presented to the emergency department with a 10-day history of fever, sinus pressure, cough, nausea, and vomiting. Figure 2 from the case shows imaging studies from the skull base to mid-thigh. Read the full case details: nej.md/4sbcTbS
FLAURA2 phase 3 trial: Osimertinib is a preferred first-line therapy for EGFR-mutated advanced NSCLC, but whether combining platinum–pemetrexed chemotherapy with osimertinib can improve overall survival is not known. Research findings are summarized in a Quick Take video. nej.md/3YFyz29
January 3, 2026 at 8:00 PM
FLAURA2 phase 3 trial: Osimertinib is a preferred first-line therapy for EGFR-mutated advanced NSCLC, but whether combining platinum–pemetrexed chemotherapy with osimertinib can improve overall survival is not known. Research findings are summarized in a Quick Take video. nej.md/3YFyz29
Causes of cardiogenic shock can be categorized according to etiologic factors: acute myocardial infarction; factors unrelated to myocardial infarction, such as new or acute-on-chronic heart failure; or secondary nonmyocardial causes and postcardiotomy shock. Learn more: nej.md/49ohKyV
January 3, 2026 at 2:15 PM
Causes of cardiogenic shock can be categorized according to etiologic factors: acute myocardial infarction; factors unrelated to myocardial infarction, such as new or acute-on-chronic heart failure; or secondary nonmyocardial causes and postcardiotomy shock. Learn more: nej.md/49ohKyV
After resistance to epidermal growth factor receptor tyrosine kinase inhibitors develops in EGFR-mutated lung cancer, treatment options are limited. Findings on sacituzumab tirumotecan, an antibody–drug conjugate targeting Trop-2, are summarized in a new Quick Take video. nej.md/49b6oNC
January 2, 2026 at 8:02 PM
After resistance to epidermal growth factor receptor tyrosine kinase inhibitors develops in EGFR-mutated lung cancer, treatment options are limited. Findings on sacituzumab tirumotecan, an antibody–drug conjugate targeting Trop-2, are summarized in a new Quick Take video. nej.md/49b6oNC
A 31-year-old woman presented with 10 days of fever, sinus pressure, cough, nausea, and vomiting. Three episodes of similar symptoms, as well as night sweats, fatigue, and weight loss, had occurred in the previous 5 months. Read the full case details: nej.md/4sbcTbS
#MedSky #IDSky #Immunology
#MedSky #IDSky #Immunology
January 2, 2026 at 2:05 PM
A 31-year-old woman presented with 10 days of fever, sinus pressure, cough, nausea, and vomiting. Three episodes of similar symptoms, as well as night sweats, fatigue, and weight loss, had occurred in the previous 5 months. Read the full case details: nej.md/4sbcTbS
#MedSky #IDSky #Immunology
#MedSky #IDSky #Immunology
New in the January 1, 2026, issue of NEJM:
Sacituzumab Tirumotecan in EGFR-TKI–Resistant NSCLC (OptiTROP-Lung04 phase 3 trial) nej.md/493hVjl
Osimertinib plus Chemotherapy in 𝘌𝘎𝘍𝘙-Mutated NSCLC (FLAURA2 phase 3 trial) nej.md/4opdBzC
Sacituzumab Tirumotecan in EGFR-TKI–Resistant NSCLC (OptiTROP-Lung04 phase 3 trial) nej.md/493hVjl
Osimertinib plus Chemotherapy in 𝘌𝘎𝘍𝘙-Mutated NSCLC (FLAURA2 phase 3 trial) nej.md/4opdBzC
January 1, 2026 at 2:34 PM
New in the January 1, 2026, issue of NEJM:
Sacituzumab Tirumotecan in EGFR-TKI–Resistant NSCLC (OptiTROP-Lung04 phase 3 trial) nej.md/493hVjl
Osimertinib plus Chemotherapy in 𝘌𝘎𝘍𝘙-Mutated NSCLC (FLAURA2 phase 3 trial) nej.md/4opdBzC
Sacituzumab Tirumotecan in EGFR-TKI–Resistant NSCLC (OptiTROP-Lung04 phase 3 trial) nej.md/493hVjl
Osimertinib plus Chemotherapy in 𝘌𝘎𝘍𝘙-Mutated NSCLC (FLAURA2 phase 3 trial) nej.md/4opdBzC