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NEJM.org @nejm.org · 1h

Case Record of the MGH: A 36-year-old man was admitted because of fever, hypoxemia, and bacteremia. Imaging revealed pulmonary opacities, thickening of the duodenal wall, and a thrombus in the right renal vein. A diagnosis was made. Full case details: nej.md/3KYBaAE

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NEJM.org @nejm.org · 4h

Targeted Indoor Spraying to Prevent Aedes-Borne Diseases nej.md/46J4e7O

Permethrin-Treated Wraps for Prevention of Malaria nej.md/4msFwwX

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NEJM.org @nejm.org · 4h

New in the October 9, 2025, issue of NEJM:

Baxdrostat Efficacy and Safety in Uncontrolled Hypertension (BaxHTN phase 3 trial) nej.md/4my7xUZ

Nexiguran Ziclumeran in ATTR with Polyneuropathy nej.md/46Qhur7

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Images and descriptions of what's new on NEJM.org this week

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NEJM.org @nejm.org · 19h

Idiopathic intracranial hypertension — high cerebrospinal fluid pressure most common in women of reproductive age with obesity — threatens vision. Treatment includes weight loss, medication, and surgery. Learn more in a new review: nej.md/3KJlVvk

#MedSky #NeuroSky #Ophthalmology

Panel A: Funduscopic images showing severe papilledema in the right and left eyes with hemorrhages and exudates.
Panel B: The right and left fundi 3 months later, with resolving papilledema after reduction in intracranial pressure (ICP) by venous sinus stenting followed by shunt repair.

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NEJM.org @nejm.org · 20h

𝘈𝘦𝘥𝘦𝘴 𝘢𝘦𝘨𝘺𝘱𝘵𝘪 mosquitoes spread chikungunya, dengue, and Zika. In a trial in Mexico, targeted indoor residual spraying led to lower mosquito levels but not lower disease risk. Full trial results: nej.md/46J4e7O

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NEJM.org @nejm.org · 20h

In a national cohort of veterans, the 2024–2025 Covid-19 vaccine was linked to reduced risks of emergency department visits, hospitalizations, and deaths from Covid-19 across the overall cohort and in various subgroups. Full study results: nej.md/47anKdz

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A graph showing the Covid-19–associated composite outcome over 180 days in the 2024–2025 vaccination season

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NEJM.org @nejm.org · 22h

GASTROSAM trial: Many children with severe acute malnutrition have complications such as gastroenteritis, often with severe dehydration. Whether intravenous rehydration is safe in such children has been unclear. Research findings are summarized in a new Quick Take video. nej.md/4pTKHJy

A visual representation of the GASTROSAM trial, which assessed intravenous rehydration therapy for children with severe acute malnutrition with gastroenteritis and severe dehydration.

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Reposted by NEJM.org

Larry Au @larryau.bsky.social · 4d

Our new NEJM commentary argues on the need to preserve state autonomy for Emergency Medicaid, and the critical role EM plays in supporting undocumented immigrants and safety net hospitals

www.nejm.org/doi/full/10....

Emergency Medicaid at Risk — Preserving State Authority and Access to Care | NEJM

States that use federal dollars to provide health care to unauthorized immigrants, beyond narrowly defined emergency services, will now face enforcement actions and potential recoupment of funds.

www.nejm.org

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NEJM.org @nejm.org · 1d

Management of Monoclonal Gammopathy of Undetermined Significance.

In low-risk patients who are younger than 50 years of age, bone marrow biopsy and imaging may be considered a baseline evaluation, given the anticipated life expectancy. Learn more: nej.md/473uOsj

#MedSky #Hematology

A diagram showing the management of monoclonal gammopathy of undetermined significance.

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NEJM.org @nejm.org · 1d

In rural South Africa, home-based hypertension care — delivered by community health workers and supported by remote nurses — led to a lower mean systolic blood pressure than clinic-based care. Full IMPACT-BP trial results and Research Summary: nej.md/4lHJ4ek

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The New England Journal of Medicine
Home-Based Care for Hypertension in Rural South Africa
A Research Summary based on Siedner MJ et al. | 10.1056/NEJMoa2509958 | Published on September 1, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

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NEJM.org @nejm.org · 1d

Plague is a high-consequence infectious disease with epidemic potential.

The latest video in our partnership with @glaucomflecken.bsky.social summarizes new research evaluating ciprofloxacin versus aminoglycoside–ciprofloxacin for bubonic plague in Madagascar. 👉 nej.md/DrG27

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NEJM.org @nejm.org · 2d

A 29-year-old woman presented with a 2-day history of painful swallowing. One week earlier, she had had a fever and sore throat. Upper endoscopy revealed multiple “volcano-like” ulcers in the middle esophagus. Read the full case details: nej.md/4nUkSqY

#MedSky #GastroSky

Panel A: Upper endoscopy revealing multiple discrete, shallow, “volcano-like” ulcers with raised edges in the middle esophagus.
Panel B: Widespread whitish exudates and friable mucosa seen in the distal esophagus.
Panel C: Histopathological testing of a biopsy specimen from an ulcer showing viral cytopathic effects in the squamous epithelial cells of the esophageal lining.

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NEJM.org @nejm.org · 2d

Clesrovimab is a long-acting monoclonal antibody against respiratory syncytial virus fusion protein. In the CLEVER phase 2b–3 trial involving 3614 healthy infants, clesrovimab reduced RSV disease and associated hospitalization. Full trial results and Research Summary: nej.md/48jpBO4

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The New England Journal of Medicine
Clesrovimab for Prevention of RSV Disease in Healthy Infants
A Research Summary based on Zar HJ et al. | 10.1056/NEJMoa2502984 | Published on September 17, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

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NEJM.org @nejm.org · 2d

IMPACT-BP trial: Poorly controlled hypertension is common, particularly in areas with structural barriers to health care. Research findings on home-based hypertension care in one such area — rural South Africa — are summarized in a new Quick Take video. nej.md/42V3hH2

#MedSky #CardioSky

A visual representation of the IMPACT-BP trial, which assessed whether home-based hypertension care would improve blood pressure in populations with numerous barriers to care in South Africa.

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NEJM.org @nejm.org · 3d

Monoclonal gammopathy of undetermined significance (MGUS) is important not only because it is the precursor to plasma-cell cancers, but also because it is causally related to numerous serious nonmalignant disorders. Learn more in a new review: nej.md/473uOsj

#MedSky #Hematology

Key points from the Review Article "Monoclonal Gammopathy of Undetermined Significance"

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NEJM.org @nejm.org · 3d

Among patients with moderate hypertriglyceridemia and high cardiovascular risk, monthly olezarsen injections resulted in significantly greater reduction in triglyceride levels at 6 months than placebo. Full Essence–TIMI 73b phase 3 trial results and Research Summary: nej.md/4mws7Vt

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The New England Journal of Medicine
Targeting APOC3 with Olezarsen in Moderate Hypertriglyceridemia
A Research Summary based on Bergmark BA et al. | 10.1056/NEJMoa2507227 | Published on August 30, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

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NEJM.org @nejm.org · 3d

CLEVER phase 2b–3 trial: The burden of severe RSV disease is highest in the first 6 months of life, when prevention is needed. Research findings on clesrovimab ― a long-acting investigational monoclonal antibody against RSV fusion protein ― are summarized in a new Quick Take video. nej.md/42FOKzd

An illustration of a healthy infant receiving a single dose of clesrovimab before or during the first RSV season.

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NEJM.org @nejm.org · 4d

A 52-year-old woman with hypertension presented with fatigue, vomiting, and confusion. Examination was notable for powdery, crystalline deposits on the arms, legs, trunk, and scalp. Read the full case details: nej.md/4pKf6tL

#MedSky #DermSky #Nephrology

Images in Clinical Medicine
Uremic Frost

Photos of the patient's right arm and left leg

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NEJM.org @nejm.org · 4d

The GASTROSAM trial involving children with severe acute malnutrition and gastroenteritis showed no evidence of a difference in mortality at 96 hours between oral and intravenous rehydration strategies. Full trial results and Research Summary: nej.md/3TjfSP7

#MedSky #PedSky #GastroSky

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NEJM.org @nejm.org · 4d

Essence–TIMI 73b phase 3 trial: Patients with hypertriglyceridemia have an increased risk of atherosclerosis and acute pancreatitis, but highly effective treatments to reduce triglyceride levels are lacking. Research findings are summarized in a new Quick Take video. nej.md/3VKPiQl

A visual representation of the Essence–TIMI 73b phase 3 trial, which evaluated olezarsen for treating patients with hypertriglyceridemia.

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NEJM.org @nejm.org · 5d

📖 Further reading 
Original Article by M.J. Bolland et al.: Fracture Prevention with Infrequent Zoledronate in Women 50 to 60 Years of Age nej.md/4g6wlz3

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NEJM.org @nejm.org · 5d

Most fragility fractures occur in patients without osteoporosis. Should we rethink who gets treated? On the latest episode of Beyond Journal Club from @coreimpodcast.bsky.social and NEJM Group, the hosts address this question and more. Listen now: nej.md/4q7hOK3

#MedSky #OrthoSky

An illustration explaining pathways to bisphosphonates

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NEJM.org @nejm.org · 5d

3️⃣ Pharmaceutical Wholesalers — Under-the-Radar Middlemen? nej.md/42QGpIM

4️⃣ “You Still Going to Be Doing This?” nej.md/42Haafl

Subscribe to NEJM for the latest medical research: nej.md/subscribe

NEJM.org @nejm.org · 5d

Weekend Briefing for October 4, 2025:

New Images in Clinical Medicine: Oral Verruciform Xanthomas nej.md/4mH8U2I

Four New Perspectives:

1️⃣ Occupational Health and Safety on the Chopping Block nej.md/3VMcttz

2️⃣ Emergency Medicaid at Risk nej.md/46MQec6

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NEJM.org @nejm.org · 5d

She reported no history of back pain. Computed tomography of the chest is shown. What is the most likely underlying etiology? nej.md/IC10022025 2/2