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Welcome to the official Bluesky account for the New England Journal of Medicine. Follow for high-quality, peer-reviewed research and clinical content from the world’s leading medical journal, online at NEJM.org.

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A new Double Take video reviews evidence-based recommendations on measles prevention and management and explores commonly asked questions about the measles virus and infection. Watch on YouTube: youtu.be/PI6M680p9i0
Measles | NEJM
YouTube video by NEJM Group
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An 80-year-old woman presented with a skin lesion on her left arm. Examination showed a brown lesion with eccentric hyperpigmented asymmetric globules adjacent to a second, pink lesion with well-defined borders. Read the full case details: nej.md/4ju9kcU

#MedSky #DermSky #Oncology
Images in Clinical Medicine Collision Lesion Panel A: A photo of a brown lesion with irregular borders adjacent to a second, pink lesion with well-defined borders and superficial scaling. Panel B: Dermoscopy of the brown and pink lesions.
January 10, 2026 at 8:01 PM
nejm.org
Published June 2025: Neoadjuvant PD-1 blockade with dostarlimab led to organ preservation in a high proportion of patients with early-stage mismatch repair–deficient tumors, with no compromise of surgical options. Read the abstract and more in the Notable Articles of 2025: nej.md/49td1Lq
Notable Articles of 2025 Nonoperative Management of Mismatch Repair–Deficient Tumors Axial PET images from Patient 25, who had mismatch repair–deficient, localized intrahepatic cholangiocarcinoma. The left image shows the tumor at baseline, and the right image shows a clinical complete response after the administration of dostarlimab therapy for 6 months. The New England Journal of Medicine
January 10, 2026 at 5:03 PM
nejm.org
PISCES trial: More than two thirds of patients receiving hemodialysis for end-stage kidney disease are affected by cardiovascular disease. Research findings on fish-oil supplementation in patients treated with hemodialysis are summarized in a new Quick Take video. nej.md/3YsyWx2

#MedSky
A visual representation of the PISCES trial, which assessed whether fish oil could prevent cardiovascular events in patients on hemodialysis.
January 10, 2026 at 2:01 PM
nejm.org
A 60-year-old man with a 30-pack-year smoking history presented to the dermatology clinic for a 2-year history of a painful rash on his palms and soles. Previous treatment with various antibacterial agents had been ineffective. 1/2

#MedSky #DermSky
January 9, 2026 at 9:06 PM
nejm.org
StepUp trial: The addition of combined oral and topical antimicrobial therapy for male partners to treatment of women for bacterial vaginosis resulted in a lower rate of recurrence within 12 weeks than treatment of the woman alone. Download the 15 Notable Articles of 2025: nej.md/49td1Lq
Notable Articles of 2025 Male-Partner Treatment to Prevent Recurrence of Bacterial Vaginosis A visual representation of the StepUp trial The New England Journal of Medicine
January 9, 2026 at 7:13 PM
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VESALIUS-CV trial: Lowering LDL cholesterol levels with evolocumab reduces the risk of cardiovascular events in patients with a previous MI or stroke, but the effect in patients without a previous MI or stroke is unknown. Research is summarized in a new Quick Take video. nej.md/4jwRuGa
A visual representation of the VESALIUS-CV trial, which examined the effect of evolocumab on the risk of major adverse cardiovascular events in patients without a previous myocardial infarction or stroke.
January 9, 2026 at 5:03 PM
nejm.org
Serogroup switching away from serogroup Y has been identified in the major ciprofloxacin-resistant 𝘕𝘦𝘪𝘴𝘴𝘦𝘳𝘪𝘢 𝘮𝘦𝘯𝘪𝘯𝘨𝘪𝘵𝘪𝘥𝘪𝘴 strain, which may impede identification of ciprofloxacin-resistant cases of 𝘕. 𝘮𝘦𝘯𝘪𝘯𝘨𝘪𝘵𝘪𝘥𝘪𝘴 infection. Learn more: nej.md/3YoBs7B
Maximum-likelihood phylogenetic tree of Neisseria meningitidis ST-3587 CC23 isolates with dual resistance from 2019 through May 1, 2024.
January 9, 2026 at 2:29 PM
nejm.org
Case Record of the Massachusetts General Hospital: A 50-year-old woman was admitted to the hospital because of fever and abdominal pain after visiting rural Brazil. Shock and disseminated intravascular coagulation developed. A diagnosis was made. Full case details: nej.md/3L2HIyT

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Case Records of the Massachusetts General Hospital A 50-Year-Old Woman with Fever and Abdominal Pain Left: An axial image from non–contrast-enhanced CT of the abdomen and pelvis. Right: A coronal reconstruction image.
January 8, 2026 at 8:02 PM
nejm.org
The 2025 edition of our annual Notable Articles collection, selected by NEJM editors, showcases the most significant contributions to clinical medicine and patient care. Download your free copy of this exclusive collection: nej.md/49td1Lq
Notable Articles of 2025 15 groundbreaking studies that will change the way you practice medicine Images from some of the articles
January 8, 2026 at 4:08 PM
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New in the January 8, 2026, issue of NEJM:

Evolocumab in Patients without Previous MI or Stroke (VESALIUS-CV trial) nej.md/4oWrIN6

Fish Oil, Cardiovascular Events, and Hemodialysis (PISCES trial) nej.md/49zWuqo

#MedSky
Images and descriptions of what's new on NEJM.org this week
January 8, 2026 at 2:03 PM
nejm.org
A 5-week-old boy was brought to the hospital with a painful scalp lump that had been present since birth. On examination, there was a tense, nonpulsatile round mass on the occiput surrounded by a ring of dark, coarse hair. Read the full case details: nej.md/3N4jkgV

#MedSky #NeuroSky #PedSky
Images in Clinical Medicine Atretic Cephalocele Panel A: A photo of the tense, nonpulsatile, 1.3-cm round mass was noted on the occiput. Panel B: MRI of the head revealing an extracranial cystic lesion with high signal intensity on T2-weighted sequences and low signal intensity on T1-weighted sequences. Blake’s pouch cyst was also incidentally identified.
January 7, 2026 at 11:00 PM
nejm.org
Functional dyspepsia is a common, heterogeneous syndrome that is linked to microinflammation and overlaps with other GI disorders. Management relies on symptom-directed medications, nutrition, and psychological support. Learn more: nej.md/4aOcRjV

#MedSky #GastroSky
Clinical Practice Functional Dyspepsia A visual representation of the proposed pathophysiological model of functional dyspepsia.
January 7, 2026 at 10:10 PM
nejm.org
An 80-year-old man presented with a 4-day history of a rash on his abdomen. Physical examination was notable for periumbilical erythema and a small gray protrusion in the umbilicus. Read the full case details: nej.md/4pYF5NO

@i-med.ac.at #MedSky #DermSky
Images in Clinical Medicine Periumbilical Erythema Migrans Panel A: A photo of the periumbilical erythema and a small gray protrusion in the umbilicus. Panels B and C: Photos of a tick being extracted from the umbilicus.
January 7, 2026 at 8:23 PM
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Three articles published in NEJM that made headlines in December.
January 7, 2026 at 2:13 PM
nejm.org
A 50-year-old woman was admitted to the hospital because of fever and abdominal pain after visiting rural Brazil. Shock and disseminated intravascular coagulation developed. What is the most likely diagnosis?

Challenge closing soon... Cast your vote now! nej.md/3Yfizns

#MedSky
January 6, 2026 at 11:24 PM
nejm.org
The authors of a new review summarize recent advances in the management and diagnosis of cardiogenic shock, including staging and therapies, and describe needs that warrant further research. Read the full review: nej.md/49ohKyV

#MedSky #CardioSky
Key points from Review Article "Cardiogenic Shock"
January 6, 2026 at 8:03 PM
nejm.org
A new Case Study in NEJM Catalyst Innovations in Care Delivery reports the results of a multiyear study of efforts to increase engagement with eligible patients through documented PrEP discussion in the primary care. Full study results: nej.md/4jjSYDL

Explore the full issue: nej.md/4j0CAHN
Case Study Improved HIV Preexposure Prophylaxis Uptake in New York City A visual representation of "PrEP Express Lane: An Electronic Medical Record Tool to Streamline Care"
January 6, 2026 at 5:06 PM
nejm.org
A 6-month-old boy was referred to a pediatric neurology clinic in Brazil for evaluation of developmental delay. CT of the head at 1 month of age had shown lissencephaly and intracranial calcifications. Read the full case details: nej.md/4qeRoVC

@ucsandiego.bsky.social #MedSky
Panel A: Prenatal ultrasonography at 12 weeks’ gestation. Panel B: Prenatal ultrasonography at 29 weeks’ gestation (axial and sagittal views). Panel C: CT of the head at 1 month of age.
January 6, 2026 at 2:03 PM
nejm.org
Three must-read articles that made news in December:

1️⃣ Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia nej.md/48wiyQL

𝗡𝗼𝘁𝗮𝗯𝗹𝗲 𝗵𝗲𝗮𝗱𝗹𝗶𝗻𝗲:

Pioneering new treatment reverses incurable blood cancer in some patients (BBC) nej.md/497Tgdp
Blood cancer therapy reverses incurable leukaemia in some patients
Seven out of 11 patients with incurable cancer who had the treatment appear to be cancer-free.
nej.md
January 5, 2026 at 10:45 PM
nejm.org
Cardiogenic shock is defined as a cardiac disorder that results in both clinical and biochemical evidence of sustained tissue hypoperfusion. Learn more about the management and diagnosis of cardiogenic shock in a new review: nej.md/49ohKyV

#MedSky #CardioSky
January 5, 2026 at 8:02 PM
nejm.org
A 𝐦𝐚𝐬𝐭 𝐜𝐞𝐥𝐥 is a tissue-resident hematopoietic effector cell that resides in vascularized tissues, with greatest densities in mucosal and cutaneous barrier tissues. Full definition of this NEJM Illustrated Glossary term: nej.md/4qnpC9J

#MedSky #PedSky #Immunology
Visual representation of a "mast cell"
January 5, 2026 at 5:09 PM
nejm.org
In an update of the BArT study, direct-acting antivirals led to durable responses in HCV-associated indolent B-cell lymphomas, with 6-year progression-free survival of 66% and no relapses after a complete response. Read the full update: nej.md/48OP2qS

#MedSky #Hematology #GastroSky
A figure showing overall survival of the 40 enrolled patients.
January 4, 2026 at 8:02 PM
nejm.org
A 31-year-old woman presented to the emergency department with a 10-day history of fever, sinus pressure, cough, nausea, and vomiting. Figure 2 from the case shows imaging studies from the skull base to mid-thigh. Read the full case details: nej.md/4sbcTbS
Imaging studies from the skull base to mid-thigh
January 4, 2026 at 2:01 PM
nejm.org
FLAURA2 phase 3 trial: Osimertinib is a preferred first-line therapy for EGFR-mutated advanced NSCLC, but whether combining platinum–pemetrexed chemotherapy with osimertinib can improve overall survival is not known. Research findings are summarized in a Quick Take video. nej.md/3YFyz29
January 3, 2026 at 8:00 PM
nejm.org
Causes of cardiogenic shock can be categorized according to etiologic factors: acute myocardial infarction; factors unrelated to myocardial infarction, such as new or acute-on-chronic heart failure; or secondary nonmyocardial causes and postcardiotomy shock. Learn more: nej.md/49ohKyV
An illustrated diagram of the causes of cardiogenic shock
January 3, 2026 at 2:15 PM