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Follow @ai.nejm.org for medical AI content.
Follow @ai.nejm.org for medical AI content.
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What is the appropriate antithrombotic regimen for patients with chronic coronary syndrome who are at high atherothrombotic risk and receiving long-term oral anticoagulation?
View the full results of the AQUATIC trial: nej.md/45AU4Wp
#MedSky #CardioSky
View the full results of the AQUATIC trial: nej.md/45AU4Wp
#MedSky #CardioSky
In patients with cardiovascular disease and an implantable cardioverter–defibrillator, increasing potassium levels to the high-normal range reduced the risk of arrhythmia events, hospitalizations, and death. Full POTCAST trial results: nej.md/4oQtHTN
#MedSky #CardioSky
#MedSky #CardioSky
November 23, 2025 at 8:01 PM
In patients with cardiovascular disease and an implantable cardioverter–defibrillator, increasing potassium levels to the high-normal range reduced the risk of arrhythmia events, hospitalizations, and death. Full POTCAST trial results: nej.md/4oQtHTN
#MedSky #CardioSky
#MedSky #CardioSky
Influenza remains an important cause of illness and death. In a phase 3 trial, a nucleoside-modified mRNA (modRNA) quadrivalent vaccine was found to be superior to a standard quadrivalent vaccine in preventing influenza illness. Full trial results and Research Summary: nej.md/43udoTG
November 23, 2025 at 2:00 PM
Influenza remains an important cause of illness and death. In a phase 3 trial, a nucleoside-modified mRNA (modRNA) quadrivalent vaccine was found to be superior to a standard quadrivalent vaccine in preventing influenza illness. Full trial results and Research Summary: nej.md/43udoTG
What are the challenges of recommending bisphosphonates to patients who have normal bone density? Dr. Ann Garment discusses this in the latest episode of Beyond Journal Club, a collaboration between @coreimpodcast.bsky.social and NEJM Group. Full episode: nej.md/4q7hOK3
#MedSky
#MedSky
November 22, 2025 at 8:01 PM
What are the challenges of recommending bisphosphonates to patients who have normal bone density? Dr. Ann Garment discusses this in the latest episode of Beyond Journal Club, a collaboration between @coreimpodcast.bsky.social and NEJM Group. Full episode: nej.md/4q7hOK3
#MedSky
#MedSky
Among older adults with frailty, evidence on the benefits and risks of discontinuing antihypertensive drugs is limited. Research findings from the RETREAT-FRAIL trial are summarized in a new Quick Take video. nej.md/482WnBv
#MedSky #CardioSky
#MedSky #CardioSky
November 22, 2025 at 5:02 PM
Among older adults with frailty, evidence on the benefits and risks of discontinuing antihypertensive drugs is limited. Research findings from the RETREAT-FRAIL trial are summarized in a new Quick Take video. nej.md/482WnBv
#MedSky #CardioSky
#MedSky #CardioSky
Joshua A. Boyce, MD, describes two studies implicating intestinally generated cysteinyl leukotrienes in food anaphylaxis. Learn more: nej.md/4rp7MEL
#MedSky #PedSky #Immunology
#MedSky #PedSky #Immunology
November 22, 2025 at 2:02 PM
Joshua A. Boyce, MD, describes two studies implicating intestinally generated cysteinyl leukotrienes in food anaphylaxis. Learn more: nej.md/4rp7MEL
#MedSky #PedSky #Immunology
#MedSky #PedSky #Immunology
Reposted by NEJM.org
A new NEJM paper just dropped evaluating a quadrivalent modified mRNA (modRNA) influenza vaccine in a phase 3 trial. This is the largest test yet of whether the mRNA platform that transformed COVID-19 vaccination can improve our fight against flu.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Efficacy, Immunogenicity, and Safety of Modified mRNA Influenza Vaccine | NEJM
Influenza remains a major health burden despite the use of licensed vaccines. Nucleoside-modified
messenger RNA (modRNA) influenza vaccines have shown promising immunogenicity against
influenza and...
www.nejm.org
November 20, 2025 at 12:26 PM
A new NEJM paper just dropped evaluating a quadrivalent modified mRNA (modRNA) influenza vaccine in a phase 3 trial. This is the largest test yet of whether the mRNA platform that transformed COVID-19 vaccination can improve our fight against flu.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
New from NEJM Catalyst Innovations in Care Delivery:
A pilot randomized controlled trial exploring the link between receiving a preferred safety device and a change in firearm-storage behavior.
Read the full article: nej.md/3JYujr2
#PublicHealth
A pilot randomized controlled trial exploring the link between receiving a preferred safety device and a change in firearm-storage behavior.
Read the full article: nej.md/3JYujr2
#PublicHealth
November 21, 2025 at 8:01 PM
New from NEJM Catalyst Innovations in Care Delivery:
A pilot randomized controlled trial exploring the link between receiving a preferred safety device and a change in firearm-storage behavior.
Read the full article: nej.md/3JYujr2
#PublicHealth
A pilot randomized controlled trial exploring the link between receiving a preferred safety device and a change in firearm-storage behavior.
Read the full article: nej.md/3JYujr2
#PublicHealth
Presented at #SVIN25:
CREST-2: In high-grade asymptomatic carotid stenosis, addition of stenting to medical therapy led to a lower risk of stroke over a 4-year period. Endarterectomy did not lead to a significant benefit. Full results: nej.md/3LK9kst
CREST-2: In high-grade asymptomatic carotid stenosis, addition of stenting to medical therapy led to a lower risk of stroke over a 4-year period. Endarterectomy did not lead to a significant benefit. Full results: nej.md/3LK9kst
November 21, 2025 at 3:38 PM
Presented at #SVIN25:
CREST-2: In high-grade asymptomatic carotid stenosis, addition of stenting to medical therapy led to a lower risk of stroke over a 4-year period. Endarterectomy did not lead to a significant benefit. Full results: nej.md/3LK9kst
CREST-2: In high-grade asymptomatic carotid stenosis, addition of stenting to medical therapy led to a lower risk of stroke over a 4-year period. Endarterectomy did not lead to a significant benefit. Full results: nej.md/3LK9kst
In patients with cardiovascular disease and low or low-normal potassium levels, whether increasing levels to the high-normal range lowers the risk for ventricular arrhythmias is unclear. Research findings from the POTCAST trial are summarized in a new Quick Take video. nej.md/49JTckP
November 21, 2025 at 2:23 PM
In patients with cardiovascular disease and low or low-normal potassium levels, whether increasing levels to the high-normal range lowers the risk for ventricular arrhythmias is unclear. Research findings from the POTCAST trial are summarized in a new Quick Take video. nej.md/49JTckP
Dr. Wright Clarkson, a family medicine resident at Virginia Mason Franciscan Health in Washington, shares how microaggressions and attitudes toward primary care physicians shaped his experience as a medical student.
November 20, 2025 at 8:35 PM
Dr. Wright Clarkson, a family medicine resident at Virginia Mason Franciscan Health in Washington, shares how microaggressions and attitudes toward primary care physicians shaped his experience as a medical student.
Case Record of the Massachusetts General Hospital: A 27-year-old man with bipolar I disorder was admitted to the hospital with abnormal behaviors and confusion. Tachycardia was present, and the patient had a seizure. A diagnosis was made. Read the full case details: nej.md/4oGQxg8
November 20, 2025 at 5:01 PM
Case Record of the Massachusetts General Hospital: A 27-year-old man with bipolar I disorder was admitted to the hospital with abnormal behaviors and confusion. Tachycardia was present, and the patient had a seizure. A diagnosis was made. Read the full case details: nej.md/4oGQxg8
New in the November 20, 2025, issue of NEJM:
Potassium for High Risk of Ventricular Arrhythmias (POTCAST trial) nej.md/4oQtHTN
Reducing Antihypertensive Drugs in Nursing Home Residents (RETREAT-FRAIL trial) nej.md/45NUK9v
#MedSky
Potassium for High Risk of Ventricular Arrhythmias (POTCAST trial) nej.md/4oQtHTN
Reducing Antihypertensive Drugs in Nursing Home Residents (RETREAT-FRAIL trial) nej.md/45NUK9v
#MedSky
November 20, 2025 at 2:06 PM
New in the November 20, 2025, issue of NEJM:
Potassium for High Risk of Ventricular Arrhythmias (POTCAST trial) nej.md/4oQtHTN
Reducing Antihypertensive Drugs in Nursing Home Residents (RETREAT-FRAIL trial) nej.md/45NUK9v
#MedSky
Potassium for High Risk of Ventricular Arrhythmias (POTCAST trial) nej.md/4oQtHTN
Reducing Antihypertensive Drugs in Nursing Home Residents (RETREAT-FRAIL trial) nej.md/45NUK9v
#MedSky
A new review summarizes the genetics, diagnosis, and treatment of long QT syndrome, a major cause of sudden death in young people. Risk stratification and genotype-guided therapy are essential. Learn more in a new Review Article: nej.md/44cxXnN
#MedSky #CardioSky
#MedSky #CardioSky
November 19, 2025 at 11:01 PM
A new review summarizes the genetics, diagnosis, and treatment of long QT syndrome, a major cause of sudden death in young people. Risk stratification and genotype-guided therapy are essential. Learn more in a new Review Article: nej.md/44cxXnN
#MedSky #CardioSky
#MedSky #CardioSky
Influenza remains an important cause of illness and death. In a phase 3 trial, a nucleoside-modified mRNA (modRNA) quadrivalent vaccine was found to be superior to a standard quadrivalent vaccine in preventing influenza illness. Full trial results: nej.md/43udoTG
#MedSky #IDSky
#MedSky #IDSky
November 19, 2025 at 10:40 PM
Influenza remains an important cause of illness and death. In a phase 3 trial, a nucleoside-modified mRNA (modRNA) quadrivalent vaccine was found to be superior to a standard quadrivalent vaccine in preventing influenza illness. Full trial results: nej.md/43udoTG
#MedSky #IDSky
#MedSky #IDSky
This cluster-randomized trial in Malawi and Uganda showed a significant benefit of an intervention to support health care providers in hand washing, preventing and managing maternal infection, and detecting and treating sepsis. Full APT-Sepsis trial results: nej.md/4o6xhaF
#MedSky #OBGYN
#MedSky #OBGYN
November 19, 2025 at 10:10 PM
This cluster-randomized trial in Malawi and Uganda showed a significant benefit of an intervention to support health care providers in hand washing, preventing and managing maternal infection, and detecting and treating sepsis. Full APT-Sepsis trial results: nej.md/4o6xhaF
#MedSky #OBGYN
#MedSky #OBGYN
The authors of a new review current knowledge of the pathophysiology and pathogenesis of acromegaly, as well as its clinical features, diagnosis, treatment, and disease course, focusing on the general clinician’s key role in early diagnosis and management. Full review: nej.md/3JPVdBg
November 19, 2025 at 8:01 PM
The authors of a new review current knowledge of the pathophysiology and pathogenesis of acromegaly, as well as its clinical features, diagnosis, treatment, and disease course, focusing on the general clinician’s key role in early diagnosis and management. Full review: nej.md/3JPVdBg
Reposted by NEJM.org
In the latest episode of the NEJM AI Grand Rounds podcast, cognitive psychologist Dr. Laura Zwaan discusses how machines inherit our biases and why both need transparency and reflection. Listen to the full episode now: nejm.ai/ep36
#AI #MedSky
#AI #MedSky
November 19, 2025 at 2:43 PM
In the latest episode of the NEJM AI Grand Rounds podcast, cognitive psychologist Dr. Laura Zwaan discusses how machines inherit our biases and why both need transparency and reflection. Listen to the full episode now: nejm.ai/ep36
#AI #MedSky
#AI #MedSky
In untreated, advanced triple-negative breast cancer, sacituzumab govitecan led to significantly longer progression-free survival than chemotherapy (9.7 months vs. 6.9 months). Full ASCENT-03 phase 3 trial results and Research Summary: nej.md/4ncuUCV
#MedSky #Oncology
#MedSky #Oncology
November 19, 2025 at 2:03 PM
In untreated, advanced triple-negative breast cancer, sacituzumab govitecan led to significantly longer progression-free survival than chemotherapy (9.7 months vs. 6.9 months). Full ASCENT-03 phase 3 trial results and Research Summary: nej.md/4ncuUCV
#MedSky #Oncology
#MedSky #Oncology
Could clesrovimab, a human RSV monoclonal antibody, reduce the incidence of RSV infection in preterm and full-term infants? Find out in the latest video in our partnership with @glaucomflecken.bsky.social. Read the full results of the CLEVER trial for free: nej.md/DrG30
November 18, 2025 at 8:03 PM
Could clesrovimab, a human RSV monoclonal antibody, reduce the incidence of RSV infection in preterm and full-term infants? Find out in the latest video in our partnership with @glaucomflecken.bsky.social. Read the full results of the CLEVER trial for free: nej.md/DrG30
ASCENT-03 phase 3 trial: Treatment options are limited for patients with advanced triple-negative breast cancer who are not eligible for PD-1 or PD-L1 inhibitors. Research findings on sacituzumab govitecan as first-line therapy are summarized in a new Quick Take video. nej.md/4oHgOLm
November 18, 2025 at 2:03 PM
ASCENT-03 phase 3 trial: Treatment options are limited for patients with advanced triple-negative breast cancer who are not eligible for PD-1 or PD-L1 inhibitors. Research findings on sacituzumab govitecan as first-line therapy are summarized in a new Quick Take video. nej.md/4oHgOLm
An 89-year-old woman with severe tricuspid regurgitation presented with fever and cough after a recent diagnosis of influenza. Prominent forehead venous pulsations were noted on examination. Read the full case details: nej.md/3LtKUn3
#MedSky #CardioSky
#MedSky #CardioSky
November 17, 2025 at 8:01 PM
An 89-year-old woman with severe tricuspid regurgitation presented with fever and cough after a recent diagnosis of influenza. Prominent forehead venous pulsations were noted on examination. Read the full case details: nej.md/3LtKUn3
#MedSky #CardioSky
#MedSky #CardioSky
Bedside clinical skills have been diminished by an overreliance on technology. A new Review Article presents educational strategies for reinvigorating the bedside encounter and shows how much can be learned from it. Learn more: nej.md/4nUirnP
#MedSky #MedEd
#MedSky #MedEd
November 17, 2025 at 2:09 PM
Bedside clinical skills have been diminished by an overreliance on technology. A new Review Article presents educational strategies for reinvigorating the bedside encounter and shows how much can be learned from it. Learn more: nej.md/4nUirnP
#MedSky #MedEd
#MedSky #MedEd
Opioid deprescribing is advised when risks of opioid use outweigh benefits. A tailored, patient-centered plan with gradual dose reduction, monitoring, and support can improve outcomes and reduce harm.
Learn more in these key points and read the full article: nej.md/4oL3fu2
#MedSky
Learn more in these key points and read the full article: nej.md/4oL3fu2
#MedSky
November 16, 2025 at 8:01 PM
Opioid deprescribing is advised when risks of opioid use outweigh benefits. A tailored, patient-centered plan with gradual dose reduction, monitoring, and support can improve outcomes and reduce harm.
Learn more in these key points and read the full article: nej.md/4oL3fu2
#MedSky
Learn more in these key points and read the full article: nej.md/4oL3fu2
#MedSky
A previously healthy 8-year-old boy presented with a 7-day history of an itchy rash on both cheeks and a lacy rash on his chest and arms. Read the full case details in the Images in Clinical Medicine article “Erythema Infectiosum”: nej.md/47XEGDv
#MedSky #PedSky #DermSky
#MedSky #PedSky #DermSky
November 16, 2025 at 5:02 PM
A previously healthy 8-year-old boy presented with a 7-day history of an itchy rash on both cheeks and a lacy rash on his chest and arms. Read the full case details in the Images in Clinical Medicine article “Erythema Infectiosum”: nej.md/47XEGDv
#MedSky #PedSky #DermSky
#MedSky #PedSky #DermSky
𝗠𝗮𝗶𝗻 𝗖𝗮𝗿𝗱𝗶𝗮𝗰 𝗙𝗲𝗮𝘁𝘂𝗿𝗲𝘀 𝗼𝗳 𝗔𝗰𝗿𝗼𝗺𝗲𝗴𝗮𝗹𝘆.
Panel A shows the main cardiac features of acromegaly. The exclamation point (middle image) indicates aortic insufficiency. Panel B shows cardiac ultrasound findings in a representative patient with acromegaly.
Learn more: nej.md/3JPVdBg
Panel A shows the main cardiac features of acromegaly. The exclamation point (middle image) indicates aortic insufficiency. Panel B shows cardiac ultrasound findings in a representative patient with acromegaly.
Learn more: nej.md/3JPVdBg
November 16, 2025 at 2:01 PM
𝗠𝗮𝗶𝗻 𝗖𝗮𝗿𝗱𝗶𝗮𝗰 𝗙𝗲𝗮𝘁𝘂𝗿𝗲𝘀 𝗼𝗳 𝗔𝗰𝗿𝗼𝗺𝗲𝗴𝗮𝗹𝘆.
Panel A shows the main cardiac features of acromegaly. The exclamation point (middle image) indicates aortic insufficiency. Panel B shows cardiac ultrasound findings in a representative patient with acromegaly.
Learn more: nej.md/3JPVdBg
Panel A shows the main cardiac features of acromegaly. The exclamation point (middle image) indicates aortic insufficiency. Panel B shows cardiac ultrasound findings in a representative patient with acromegaly.
Learn more: nej.md/3JPVdBg