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NEJM.org @nejm.org · 1m

Management of Monoclonal Gammopathy of Undetermined Significance.

In low-risk patients who are younger than 50 years of age, bone marrow biopsy and imaging may be considered a baseline evaluation, given the anticipated life expectancy. Learn more: nej.md/473uOsj

#MedSky #Hematology

A diagram showing the management of monoclonal gammopathy of undetermined significance.

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NEJM.org @nejm.org · 3h

In rural South Africa, home-based hypertension care — delivered by community health workers and supported by remote nurses — led to a lower mean systolic blood pressure than clinic-based care. Full IMPACT-BP trial results and Research Summary: nej.md/4lHJ4ek

#MedSky #CardioSky

The New England Journal of Medicine
Home-Based Care for Hypertension in Rural South Africa
A Research Summary based on Siedner MJ et al. | 10.1056/NEJMoa2509958 | Published on September 1, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

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NEJM.org @nejm.org · 21h

Plague is a high-consequence infectious disease with epidemic potential.

The latest video in our partnership with @glaucomflecken.bsky.social summarizes new research evaluating ciprofloxacin versus aminoglycoside–ciprofloxacin for bubonic plague in Madagascar. 👉 nej.md/DrG27

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NEJM.org @nejm.org · 23h

A 29-year-old woman presented with a 2-day history of painful swallowing. One week earlier, she had had a fever and sore throat. Upper endoscopy revealed multiple “volcano-like” ulcers in the middle esophagus. Read the full case details: nej.md/4nUkSqY

#MedSky #GastroSky

Panel A: Upper endoscopy revealing multiple discrete, shallow, “volcano-like” ulcers with raised edges in the middle esophagus.
Panel B: Widespread whitish exudates and friable mucosa seen in the distal esophagus.
Panel C: Histopathological testing of a biopsy specimen from an ulcer showing viral cytopathic effects in the squamous epithelial cells of the esophageal lining.

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NEJM.org @nejm.org · 1d

Clesrovimab is a long-acting monoclonal antibody against respiratory syncytial virus fusion protein. In the CLEVER phase 2b–3 trial involving 3614 healthy infants, clesrovimab reduced RSV disease and associated hospitalization. Full trial results and Research Summary: nej.md/48jpBO4

#MedSky

The New England Journal of Medicine
Clesrovimab for Prevention of RSV Disease in Healthy Infants
A Research Summary based on Zar HJ et al. | 10.1056/NEJMoa2502984 | Published on September 17, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

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NEJM.org @nejm.org · 1d

IMPACT-BP trial: Poorly controlled hypertension is common, particularly in areas with structural barriers to health care. Research findings on home-based hypertension care in one such area — rural South Africa — are summarized in a new Quick Take video. nej.md/42V3hH2

#MedSky #CardioSky

A visual representation of the IMPACT-BP trial, which assessed whether home-based hypertension care would improve blood pressure in populations with numerous barriers to care in South Africa.

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NEJM.org @nejm.org · 2d

Monoclonal gammopathy of undetermined significance (MGUS) is important not only because it is the precursor to plasma-cell cancers, but also because it is causally related to numerous serious nonmalignant disorders. Learn more in a new review: nej.md/473uOsj

#MedSky #Hematology

Key points from the Review Article "Monoclonal Gammopathy of Undetermined Significance"

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NEJM.org @nejm.org · 2d

Among patients with moderate hypertriglyceridemia and high cardiovascular risk, monthly olezarsen injections resulted in significantly greater reduction in triglyceride levels at 6 months than placebo. Full Essence–TIMI 73b phase 3 trial results and Research Summary: nej.md/4mws7Vt

#MedSky

The New England Journal of Medicine
Targeting APOC3 with Olezarsen in Moderate Hypertriglyceridemia
A Research Summary based on Bergmark BA et al. | 10.1056/NEJMoa2507227 | Published on August 30, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

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NEJM.org @nejm.org · 2d

CLEVER phase 2b–3 trial: The burden of severe RSV disease is highest in the first 6 months of life, when prevention is needed. Research findings on clesrovimab ― a long-acting investigational monoclonal antibody against RSV fusion protein ― are summarized in a new Quick Take video. nej.md/42FOKzd

An illustration of a healthy infant receiving a single dose of clesrovimab before or during the first RSV season.

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NEJM.org @nejm.org · 3d

A 52-year-old woman with hypertension presented with fatigue, vomiting, and confusion. Examination was notable for powdery, crystalline deposits on the arms, legs, trunk, and scalp. Read the full case details: nej.md/4pKf6tL

#MedSky #DermSky #Nephrology

Images in Clinical Medicine
Uremic Frost

Photos of the patient's right arm and left leg

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NEJM.org @nejm.org · 3d

The GASTROSAM trial involving children with severe acute malnutrition and gastroenteritis showed no evidence of a difference in mortality at 96 hours between oral and intravenous rehydration strategies. Full trial results and Research Summary: nej.md/3TjfSP7

#MedSky #PedSky #GastroSky

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NEJM.org @nejm.org · 3d

Essence–TIMI 73b phase 3 trial: Patients with hypertriglyceridemia have an increased risk of atherosclerosis and acute pancreatitis, but highly effective treatments to reduce triglyceride levels are lacking. Research findings are summarized in a new Quick Take video. nej.md/3VKPiQl

A visual representation of the Essence–TIMI 73b phase 3 trial, which evaluated olezarsen for treating patients with hypertriglyceridemia.

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NEJM.org @nejm.org · 4d

📖 Further reading 
Original Article by M.J. Bolland et al.: Fracture Prevention with Infrequent Zoledronate in Women 50 to 60 Years of Age nej.md/4g6wlz3

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NEJM.org @nejm.org · 4d

Most fragility fractures occur in patients without osteoporosis. Should we rethink who gets treated? On the latest episode of Beyond Journal Club from @coreimpodcast.bsky.social and NEJM Group, the hosts address this question and more. Listen now: nej.md/4q7hOK3

#MedSky #OrthoSky

An illustration explaining pathways to bisphosphonates

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NEJM.org @nejm.org · 4d

3️⃣ Pharmaceutical Wholesalers — Under-the-Radar Middlemen? nej.md/42QGpIM

4️⃣ “You Still Going to Be Doing This?” nej.md/42Haafl

Subscribe to NEJM for the latest medical research: nej.md/subscribe

NEJM.org @nejm.org · 4d

Weekend Briefing for October 4, 2025:

New Images in Clinical Medicine: Oral Verruciform Xanthomas nej.md/4mH8U2I

Four New Perspectives:

1️⃣ Occupational Health and Safety on the Chopping Block nej.md/3VMcttz

2️⃣ Emergency Medicaid at Risk nej.md/46MQec6

#MedSky

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NEJM.org @nejm.org · 4d

She reported no history of back pain. Computed tomography of the chest is shown. What is the most likely underlying etiology? nej.md/IC10022025 2/2

NEJM.org @nejm.org · 4d

A 21-year-old woman who had presented to the pulmonary clinic with a 7-day history of sore throat and cough was noted to have a vertebral abnormality on chest radiograph. 1/2

#MedSky #PulmSky

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NEJM.org @nejm.org · 5d

Among adults with pulmonary arterial hypertension who had received the diagnosis less than 1 year earlier, the addition of sotatercept to background therapy resulted in a lower risk of clinical worsening than placebo. Full HYPERION phase 3 trial results and Research Summary: nej.md/4mzuaY1

The New England Journal of Medicine
Sotatercept for Pulmonary Arterial Hypertension within the First Year
A Research Summary based on McLaughlin VV et al. | 10.1056/NEJMoa2508170 | Published on September 30, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

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NEJM.org @nejm.org · 5d

3️⃣ Pill Version of Ozempic and Wegovy Leads to 13% Weight Loss in Study (TODAY) nej.md/3KtmMQV

📄 Full OASIS 4 trial: nej.md/4nFVWmZ

Ozempic in Pill Form Leads to 'Significant Weight Loss' in Trial

Pharmaceutical companies are racing to develop a GLP-1 weight-loss drug in pill form. Novo Nordisk says its oral semaglutide pill led to "significant weight loss" in a trial.

nej.md

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NEJM.org @nejm.org · 5d

2️⃣ Daily Aspirin Reduces Colon Cancer Risk (HealthDay) nej.md/4mOwYRg

📄 Full ALASCCA trial: nej.md/4mpKXNp

Daily Aspirin Reduces Colon Cancer Risk: Study

WEDNESDAY, Jan. 29, 2025 (HealthDay News) -- Daily low-dose aspirin can help prevent cancers from returning in about a third of colon cancer patients, a new stu

nej.md

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NEJM.org @nejm.org · 5d

Here are three headlines from September covering major clinical trials published in NEJM:

1️⃣ Daily weight loss pill can help cut body weight by a fifth, trial shows (The Guardian) nej.md/48cDPk0

📄 Full ATTAIN-1 trial: nej.md/4n1nSl2

Daily weight loss pill can help cut body weight by a fifth, trial shows

One in five people who took orforglipron once a day for 72 weeks lost 20% or more of their weight, maker Eli Lilly says

nej.md

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NEJM.org @nejm.org · 5d

To learn more about this term, read the editorial “Replacement of Beta Cells for Type 1 Diabetes” by Kevan C. Herold, MD, and Jordan S. Pober, MD, PhD: nej.md/469fCbF

Explore more terms: nej.md/glossary

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NEJM.org @nejm.org · 5d

A 𝐧𝐚𝐭𝐮𝐫𝐚𝐥 𝐤𝐢𝐥𝐥𝐞𝐫 (𝐍𝐊) 𝐜𝐞𝐥𝐥 is a type of cytotoxic lymphocyte critical to the function of the innate immune system.

#MedSky #EndoSky #Genetics

A visual representation of a natural killer (NK) cell

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NEJM.org @nejm.org · 5d

For a student with strep throat and an unconfirmed penicillin allergy, would you prescribe a nonpenicillin antibiotic or give penicillin under doctor supervision? Read the case vignette and essays on both treatment options and cast your vote: nej.md/48eHjm9

#MedSky #MedEd

An illustration of a patient with strep throat, a box of penicillin, and the patient's medical record

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