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GlyCosmos

@glycosmos.bsky.social

57 followers 85 following 17 posts

An official account for GlyCosmos Portal. The GlyCosmos Portal is a Web portal aiming to integrate the glycosciences with the life sciences. It consists of Standards, Repositories and Data Resources, providing information about genes, proteins, etc.

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GlyCosmos @glycosmos.bsky.social · Nov 19

🧬GlyCosmos 🧬

Bridging glycoinformatics and cheminformatics: integration efforts between GlyCosmos and PubChem

academic.oup.com/glycob/artic...

Bridging glycoinformatics and cheminformatics: integration efforts between GlyCosmos and PubChem

Abstract. The GlyCosmos Glycoscience Portal (https://glycosmos.org) and PubChem (https://pubchem.ncbi.nlm.nih.gov/) are major portals for glycoscience and

academic.oup.com

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Reposted by GlyCosmos

Chris Ashwood @cashwood.proteaglyco.com · Sep 4

Have we made it to the point where we can sneak in Pokémon names as method acronyms, relatively undetected?

PastelBio @pastelbio.bsky.social · Sep 4

Protocol for label-free ribosome-associated protein enrichment from mammalian cells by RAPIDASH www.sciencedirect.co...

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#proteomics #prot-paper

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Reposted by GlyCosmos

Harvard Med Cell Biology @harvardcellbio.bsky.social · Jun 21

New work from @xingulab.bsky.social @sshaolab.bsky.social & Elledge lab report structure of Midnolin-proteasome complex & its role in controlling myeloma via ubiquitin-independent degradation. www.cell.com/molecular-ce...

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

Nardone et al. elucidate the mechanism of the midnolin-proteasome pathway, showing how midnolin achieves nuclear substrate selection and how established proteasomal components are repurposed to enable...

www.cell.com

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Reposted by GlyCosmos

kiyokof.bsky.social @kiyokof.bsky.social · Jun 27

An exciting #glycotime meeting planned covering anything glycan ranging from carbohydrate chemistry, analytics, immunology to informatics with speakers from around the world!

SfG @sfglycobiology.bsky.social · Jun 26

🚨Abstract submissions and Travel Award applications to SFG's 2025 World Glyco Expo Annual Meeting 🎉

You must register for the conference prior to submitting your abstract! Deadline July 11th at 11:59 PM (ET), don’t miss the early bird rates! Details ⬇️

www.glycobiology.org/2025-annual-...

banner for the 2025 SfG Annual Meeting with a picture of a marina on the left at sunset (orange) with boats (blue)

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Reposted by GlyCosmos

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Jun 12

Thank you to the scientists and staff at NIH/NCATS for spending the day showing me your impressive facilities for translational science and drug development. Bringing hope to patients with unmet need 🙏 🇺🇸

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Reposted by GlyCosmos

Daniel Bojar @dbojar.bsky.social · May 27

glycowork v1.6 is out & we're now at 1,000 commits in almost 4 years! Next to Universal Input and a better GlycoDraw, we have a faster back-end, bigger&better datasets, more convenience, and so much more
github.com/BojarLab/gly...

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GlyCosmos @glycosmos.bsky.social · Jun 12

[Update] LM-GlycoRepo repository

The GlyCosmos Portal has released a novel "LM-GlycoRepo" repository for lectin-assisted multimodal (LM) data, including lectin microarrays. Version. 1.0 is introduced in a recently published article in the Journal of Proteome Research: doi.org/10.1021/acs....

LM-GlycoRepo Version 1.0: A Novel Repository System for Mouse Tissue Glycome Mapping Data

Lectin microarray (LMA) is a high-sensitive profiling method of protein glycosylation. The increasing use of this method in many studies has led to a growing demand for a repository system that meets ...

doi.org

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Reposted by GlyCosmos

Daniel Bojar @dbojar.bsky.social · May 12

A few GlycoDraw-related highlights of the upcoming glycowork v1.6 update (dropping in a few weeks):
- our very own rendering engine (GlycoDraw for the masses, thanks to glycorender!);
- SNFG-gradients;
- automated Alt text;
- reverse-highlighting;
- even more support for highly complex sequences

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Reposted by GlyCosmos

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · May 7

Nice #glycotime review that pulls together the emerging story of glycosyltransferase specificity for cellular substrates

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Glycoproteins, Glycolipids, or Both: Why do Glycosyltransferases Recognize Different Acceptors?

Glycosylation is an important post-translational modification catalyzed by glycosyltransferases (GTs), which comprise a large group of enzymes with diversified specificity. Most GTs show high specifi...

chemistry-europe.onlinelibrary.wiley.com

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GlyCosmos @glycosmos.bsky.social · May 23

🌲GlyGen

GlyGen is a global initiative funded by NIH and NIGMS to support glycoscience research by integrating diverse data from glycomics, genomics, proteomics, and biochemistry. It unifies information from multiple international sources into a single platform.

glygen.org/home/

GlyCosmos @glycosmos.bsky.social · Mar 26

🐝 GlyCounter

An intuitive platform designed for seamless integration into glycoproteomic workflows, enabling users to enhance sample and data preparation, and post-acquisition identification by simply evaluating the glycan content within glycoproteomic datasets.

www.biorxiv.org/content/10.1...

Extracting informative glycan-specific ions from glycopeptide MS/MS spectra with GlyCounter

Glycopeptide tandem mass spectra typically contain numerous glycan-specific fragments that can inform several features of glycan modifications, including glycan class, composition, and structure. Whil...

www.biorxiv.org

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Reposted by GlyCosmos

Soragni:Lab @alice.soragnilab.com · Mar 18

The NCI grant supporting the Columbia comprehensive cancer center was terminated. Tell me how terminating support for cancer research helps the economy.

taggs.hhs.gov/Content/Data...

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Reposted by GlyCosmos

Stanford Medicine @stanfordmedicine.bsky.social · Mar 18

Thousands joined this year’s SHE (Stanford Health Empowerment) Talks—online and in person—for an essential convo on brain health w/ Karen Adams, MD, and Sharon Sha, MD. They shared real steps women can take to support brain function for years to come.
youtu.be/BwtKYocLrgo?...

SHE Talks 2025: Secrets to Brain Vitality

YouTube video by Stanford Medicine

youtu.be

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Reposted by GlyCosmos

GlyGen @glygen.bsky.social · Dec 18

Discover how mass spectrometry is revolutionizing vaccine development and infectious disease research! Watch Dr. John Cipollo's insightful GlyGen Webinar now: youtu.be/-5e8MaD8yKI
Don't forget to follow and subscribe for more cutting-edge science content! 🔔
#FDA #glycotime

John Cipollo - Mass Spectrometry Driven Glycoconjugate Analysis

YouTube video by GlyGen myGlyGen

youtu.be

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Reposted by GlyCosmos

GlycoNet @glyconet.bsky.social · Feb 6

🚨 Hiring – Chaire Professeur Junior (CPJ) in Carbohydrate Chemistry! 🚨

ICBMS (Lyon, France) seeks a tenure-track researcher in oligosaccharide & glycoconjugate synthesis.

Learn more: canadianglycomics.ca/training/opp...

Opportunities - Canadian Glycomics Network

Linkedin-in Twitter Facebook-f Instagram Youtube Envelope Main Menu About About GlycoNet People Administration Corporate Policies Governance Board of Directors Executive Committee Finance, Audit & Ris...

canadianglycomics.ca

GlyCosmos @glycosmos.bsky.social · Feb 4

🌹GlyCosmos Youtube Channel

Not sure how to use the GlyCosmos tools? No worries! We’ve provided tutorial videos to guide you through the process. Check them out and get started! #Glycan #Database

www.youtube.com/@glycosmosch...

GlyCosmos

www.youtube.com

Reposted by GlyCosmos

Bacterial Genomics @bactgenrss.bsky.social · Jan 28

Discovery of two novel Flavobacterium species with potential for complex polysaccharide degradation www.nature.com/articles/s41...

Discovery of two novel Flavobacterium species with potential for complex polysaccharide degradation - Scientific Reports

Scientific Reports - Discovery of two novel Flavobacterium species with potential for complex polysaccharide degradation

www.nature.com

Reposted by GlyCosmos

UniTmp @unitmporg.bsky.social · Feb 1

Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9g95

royalsocietypublishing.org

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GlyCosmos @glycosmos.bsky.social · Jan 30

🛰️ Materials Project

The Materials Project computes the properties of all inorganic materials and provides the data, along with analysis algorithms, freely to materials researchers. It serves as an excellent resource for materials design. #database #BerkeleyLab

next-gen.materialsproject.org

GlyCosmos @glycosmos.bsky.social · Jan 30

🦠ChEMBL

Are you looking for data on bioactive molecules with drug-like properties? ChEMBL brings together chemical, bioactivity, and genomic data to aid the translation of genomic information into effective new drugs. #database

www.ebi.ac.uk/chembl/

ChEMBL - ChEMBL

www.ebi.ac.uk

GlyCosmos @glycosmos.bsky.social · Jan 30

This research presents a framework that guarantees statistical reliability based on user-defined risk and delivers calibrated probabilities instead of raw ML scores for any protein search model. More details 👇

www.nature.com/articles/s41...

Functional protein mining with conformal guarantees - Nature Communications

This study presents a protein search framework with conformal prediction, enabling statistically reliable annotation of protein function. The method improves homology search, enzyme classification, an...

www.nature.com

Reposted by GlyCosmos

Innovative Genomics Institute @innovativegenomics.bsky.social · Jan 6

With a new $1.25 million gift from @rsrt.bsky.social to @jenniferdoudna.bsky.social & @doudna-lab.bsky.social postdoc Kai Chen, IGI is developing lipid nanoparticles for editing the brain to treat Rett syndrome & other brain disorders. Read more: ow.ly/PVSy50UACMH

🧬 🧠

IGI is Awarded New Funding to Develop CRISPR Tools for Editing the Brain

A new project co-led by IGI founder Jennifer Doudna and Doudna lab researcher Kai Chen has been awarded $1.25 million from the Rett Syndrome Research Trust (RSRT) to develop CRISPR genome-editing tool...

innovativegenomics.org

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GlyCosmos @glycosmos.bsky.social · Jan 24

🌲 IMEx - The International Molecular Consortium

IMEx is a database providing physical molecular interaction data from a broad taxonomic range of organisms. You can find detailed protein-protein/protein-glycan interaction data curated from publications. #protein #glycan

imexconsortium.org

imexconsortium.org

GlyCosmos @glycosmos.bsky.social · Jan 18

🪲UniLectin🪲
UniLectin is a specialized database focused on lectins that play critical roles in various biological processes. The platform offers detailed information on lectin sequences, structures, carbohydrate-binding specificities, and biological functions.
pubmed.ncbi.nlm.nih.gov/37889052/

HumanLectome, an update of UniLectin for the annotation and prediction of human lectins - PubMed

The UniLectin portal (https://unilectin.unige.ch/) was designed in 2019 with the goal of centralising curated and predicted data on carbohydrate-binding proteins known as lectins. UniLectin is also in...

pubmed.ncbi.nlm.nih.gov

GlyCosmos @glycosmos.bsky.social · Jan 16

🌴 GlycoShape

GlycoShape is an OA database that provides 3D structural data and information on glycans, which can be downloaded or used with Re-Glyco to reconstruct glycoproteins from the RCSB PDB or EMBL-EBI AlphaFold repositories.

glycoshape.org

GlycoShape

GlycoShape is an OA database of glycans 3D structural data and information that can be downloaded or used with Re-Glyco to rebuild glycoproteins from the RCSB PDB or EMBL-EBI AlphaFold repositories

glycoshape.org

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Reposted by GlyCosmos

Sarafan ChEM-H @stanford-chemh.bsky.social · Dec 31

#YearInReview A needle-free, affordable vaccine could be on the horizon, thanks to groundbreaking research led by @mfgrp.bsky.social & @djenetbousbaine.bsky.social . The key? A harmless skin bacterium: https://buff.ly/4gORu1L

“We all hate needles — everybody does.”

Institute Scholar Michael Fischbach, Djenet Bousbaine, and team’s findings in mice could turn skin bacterium S. epidermidis into a cheap, needle-free vaccine that won’t cause inflammation or make you feel sick. Clinical trials could start in 2-3 years.

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