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Gordian Biotechnology

@gordianbio.bsky.social

43 followers 2 following 26 posts

Our mission is to cure age-related disease by moving successful therapeutics toward clinical trials within months, not years. #CreatingTime

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Gordian Biotechnology @gordianbio.bsky.social · Nov 20

The success of AI applied to drug discovery is being decided by a number of clinical trials. So far, the results are lackluster. Why? For AI to have a transformational effect in drug discovery, training data must come from living mammals. (🧵1/9)

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Reposted by Gordian Biotechnology

Vinay Kartha @vkartha.bsky.social · Jul 6

Excited to be attending this year's Human genetics and genomics Gordon Research Conference in Portland, ME, where I'll be presenting work from @gordianbio.bsky.social related to our in vivo mosaic screening platform applied to accelerate patient-relevant target discovery in complex diseases!

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Gordian Biotechnology @gordianbio.bsky.social · May 16

This news should instill urgency and remind us to ask ‘why not sooner?’.
@martinbjensen.bsky.social shared a long-term vision for how cures could become abundant, if we believe fast, systematic cure discovery is possible, and build the tools to make it happen.
www.gordian.bio/blog/cures-o...

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Gordian Biotechnology @gordianbio.bsky.social · Mar 25

The post was also published by nonprofit organization for aging research, Norn Group.

Read it here: www.gordian.bio/blog/gene-th...

Gordian Biotechnology @gordianbio.bsky.social · Mar 25

Check out chief science officer @martinbjensen.bsky.social’s post tackling misconceptions about AAV gene therapy only being best suited for rare diseases, and how factors like cost would be very different for common diseases like Parkinson’s, heart failure, and arthritis.

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Gordian Biotechnology @gordianbio.bsky.social · Mar 20

Chase’s work is a key piece of Mosaic Screening, the phase of the Gordian Platform where we create a pooled library of hundreds of therapies and test them in vivo in individual Patient Avatars.
#GeneTherapy
#Biotech
#DrugDiscovery

Gordian Biotechnology @gordianbio.bsky.social · Mar 20

Basically speaking, he’s using a spinning technique to separate and collect the small viruses delivering gene therapies without the cells they were made in, then preparing the pure sample for the next steps of the research and development process.

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Gordian Biotechnology @gordianbio.bsky.social · Mar 20

Check out vector engineering research associate Chase Bowman performing ultracentrifugation density gradient separation. Not familiar with the process?

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Gordian Biotechnology @gordianbio.bsky.social · Mar 13

We used the time to celebrate everything we’ve accomplished over the past year and map out ambitious plans for clinical development of our lead therapies!

#Biotech
#TeamBonding
#InVivoResearch

Gordian Biotechnology @gordianbio.bsky.social · Mar 13

Last month, we traded the lab for the mountains, heading to Tahoe for a well-earned winter retreat. 🏔️⛷️

As evidenced in the photos, the weather cooperated, and we all were rejuvenated by the gorgeous scenery, time outdoors, and team bonding.

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Gordian Biotechnology @gordianbio.bsky.social · Mar 6

But at Gordian, we believe that allowing talented and deserving researchers like Alex to contribute on the same level without having to pause their careers to go back to school will advance our mission and offer enrichment and opportunity that wouldn’t be available academically.

Gordian Biotechnology @gordianbio.bsky.social · Mar 6

Traditionally, securing a scientist title usually requires a PhD.

Gordian Biotechnology @gordianbio.bsky.social · Mar 6

Big (belated) congrats to Alex Araki! 🎉 Formerly a research associate on our in vivo team, Alex defended his thesis & earned a well-deserved promotion to scientist! We’re so proud of him and excited to see all the amazing work he’ll do in this next chapter!

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Gordian Biotechnology @gordianbio.bsky.social · Feb 3

Listen to the liveliest description of the Gordian platform yet! www.kqed.org/radio/progra...

Gordian Biotechnology @gordianbio.bsky.social · Feb 3

ICYMI, co-founders Francisco LePort and @martinbjensen.bsky.social were guests of Dr. Moira Gunn on the BioTech Nation podcast.

It ran on our hometown NPR station KQED and about 200 other @npr.org affiliates.

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Gordian Biotechnology @gordianbio.bsky.social · Jan 30

Listen now: www.biotechnation.com/episodes/rep...

BioTech Nation ... with Dr. Moira Gunn | Reprogramming the Future... Dr. Martin Borch Jensen and Dr. Francisco LePort, Gordian Biotechnology

This week on Biotech Nation, Dr. Martin Borch Jensen and Dr. Francisco LePort from Gordian Biotechnology share a bold new approach to fighting diseases of aging before they take hold. Instead of te...

www.biotechnation.com

Gordian Biotechnology @gordianbio.bsky.social · Jan 30

It’s exciting to hear about complex scientific topics in such a high-energy, accessible conversation. Big thanks to the always-captivating Dr. Gunn and her crew!

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Gordian Biotechnology @gordianbio.bsky.social · Jan 30

The latest episode dropped today, featuring co-founders Francisco LePort and Martin Borch Jensen discussing how Gordian’s high-throughput in vivo screening platform will transform drug discovery for age-related disease.

Gordian Biotechnology @gordianbio.bsky.social · Jan 30

If you don’t already subscribe to the BioTech Nation podcast with Dr. Moira Gunn, you will now!

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Gordian Biotechnology @gordianbio.bsky.social · Nov 20

Read more here: www.gordian.bio/blog/drug-di... (🧵9/9)

Gordian Biotechnology @gordianbio.bsky.social · Nov 20

Current applications of AI to drug discovery miss the forest for the trees. AI makes the existing drug discovery paradigm more efficient, but fails to correct structural flaws in the legacy discovery process. This has led to questionable success so far. (🧵8/9)

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Gordian Biotechnology @gordianbio.bsky.social · Nov 20

By training and screening in vivo, our predictions for in vivo results are automatically, dramatically better. This isn’t because we use better AI or more advanced assays. This is because our training data comes from the same system as our validation data. (🧵7/9)

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Gordian Biotechnology @gordianbio.bsky.social · Nov 20

Gordian has redesigned the preclinical process from the ground up. All drug developers must validate in animals. Gordian trains for discovery in animals from step one. Our preclinical discovery process takes place entirely in vivo. (🧵6/9)

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Gordian Biotechnology @gordianbio.bsky.social · Nov 20

This means drug discovery models are being trained in the wrong system. You don’t train a self-driving car on the California Vehicle Code, you train it on the road. If you’re going to test your drug in a living mammal, you must train for discovery in that living mammal. (🧵5/9)

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Gordian Biotechnology @gordianbio.bsky.social · Nov 20

A tell-tale sign that we haven’t taken full advantage of new tools and AI is that souped up preclinical processes look essentially the same, just with AI and robotics added. Here is Recursion’s 17 step preclinical process: bit.ly/4fwB2TF. In vivo validation doesn’t come until step 17. (🧵4/9)

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Gordian Biotechnology @gordianbio.bsky.social · Nov 20

AI, robotics, and new -omics have made this process much more efficient, but it is still the same fundamental discovery process. This image pulled from a quick Google search summarizes the process in 12 (not so) easy steps. In vivo validation comes in at step 12. (🧵3/9)

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