Guillermo Diez
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guillermo-diez.bsky.social
Guillermo Diez
@guillermo-diez.bsky.social
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BHF PhD student at UCL | Bioinformatics 💻| Endothelial cells 🔴
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Reposted by Guillermo Diez
giocanu.bsky.social
As a great way to start the new year, our paper has just been published!

We defined pathways driving early hematopoietic development in the mouse embryo and identified and validated new markers for hemogenic endothelium and hematopoietic progenitors.

www.mdpi.com/2221-3759/14...
January 6, 2026 at 4:46 PM
Reposted by Guillermo Diez
dev-journal.bsky.social
A Pax3 lineage gives rise to transient haematopoietic progenitors

Read this #OpenAccess Research Report by Giovanni Canu @giocanu.bsky.social, Christiana Ruhrberg @uclnews.bsky.social and colleagues:
https://doi.org/10.1242/dev.202924
Figure 1 (B) Representative immunofluorescence staining with the indicated markers of a E12.5 Pax3Cre;RosatdTom embryo section at the level of the foetal liver (FL, dotted outline); n=3 embryos. The dorsal (D), ventral (V), right (R) and left (L) side of the embryo are indicated. The dashed squares indicate two areas shown at higher magnification in the adjacent panels to visualise tdTOM+ CD45+ haematopoietic cells (arrowheads in panel 1) and tdTOM+ KDR+ endothelial cells (arrows in panel 2).
December 13, 2024 at 9:51 AM
guillermo-diez.bsky.social
Congrats @giocanu.bsky.social from UCL's Ruhrberg Lab for spotting a new hematopoietic embryonic cell type!

It was such a nice experience to discuss and contribute to this project 😃

All about it here:
journals.biologists.com/dev/article/...

#AcademicSky
@dev-journal.bsky.social
A Pax3 lineage gives rise to transient haematopoietic progenitors
Summary: Pax3-expressing cells generate neural crest and paraxial mesoderm. Here, we show that they also produce transient haematopoietic progenitors capable of generating embryonic myeloid and erythr...
journals.biologists.com
December 10, 2024 at 5:01 PM