guiomarsolanas.bsky.social
@guiomarsolanas.bsky.social
42 followers 47 following 4 posts
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guiomarsolanas.bsky.social
guiomarsolanas.bsky.social @guiomarsolanas.bsky.social · Apr 23
Thank you for the amazing insights you’ve given us along the way!! Your contribution has been key for the final manuscript!
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guiomarsolanas.bsky.social
guiomarsolanas.bsky.social @guiomarsolanas.bsky.social · Apr 23
Amazing thread on out latest preprint!!! Kudos @juliabonjoch.bsky.social
juliabonjoch.bsky.social
Júlia Bonjoch @juliabonjoch.bsky.social · Apr 23
Hi Bluesky community:)

Our new manuscript is now available as a preprint!⛅️
biorxiv.org/content/10.1...

1/ Here, we describe a novel BMAL1-YAP complex in epidermal cells, which is hijacked during ageing to control the expression of up-regulated inflammation genes through enhancer binding.🧵
BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis
Ageing is characterised by persistent low-grade inflammation that is linked to impaired tissue homeostasis and functionality. However, the molecular mechanisms driving age-associated inflammation rema...
biorxiv.org
1 1 3
guiomarsolanas.bsky.social
guiomarsolanas.bsky.social @guiomarsolanas.bsky.social · Apr 23
In this work, we uncover how a BMAL1–YAP transcriptional complex, crucial for maintaining epidermal identity in adult skin, is hijacked during ageing to drive inflammation by rewiring enhancer landscapes. It has been a long ride, but fun to share with @juliabonjoch.bsky.social and Paloma Solá
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guiomarsolanas.bsky.social
guiomarsolanas.bsky.social @guiomarsolanas.bsky.social · Apr 23
🌟 Excited to share that our latest preprint is now available! We’re one step closer to understanding the complex mechanisms behind ageing and inflammation.
👉 Read the preprint here: www.biorxiv.org/cgi/content/...
Thank you to everyone who supported and believed in this project along the way!
BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis
Ageing is characterised by persistent low-grade inflammation that is linked to impaired tissue homeostasis and functionality. However, the molecular mechanisms driving age-associated inflammation rema...
www.biorxiv.org
1 1 1