Munir “Gunes” Kutlu
@guneskutlu.bsky.social
Behavioral Neuroscientist; Assistant Professor at Center for Substance Abuse Research (CSAR) at Temple University Lewis Katz School of Medicine; Immigrant; Atlas and Nova Ela’s dad
Kutlulab.com
Kutlulab.com
➡️ In short: DLS ACh doesn’t just signal threat. It primes the striatum to expect it.
— End 🧵
— End 🧵
December 13, 2025 at 2:24 PM
➡️ In short: DLS ACh doesn’t just signal threat. It primes the striatum to expect it.
— End 🧵
— End 🧵
ACh also reorganizes DLS neural ensembles, expanding both excited and inhibited populations and shifting the network into a threat-biased state.
December 13, 2025 at 2:24 PM
ACh also reorganizes DLS neural ensembles, expanding both excited and inhibited populations and shifting the network into a threat-biased state.
Optogenetically increasing DLS ACh release accelerates threat learning and impairs extinction, biasing behavior toward persistent threat expectancy.
December 13, 2025 at 2:24 PM
Optogenetically increasing DLS ACh release accelerates threat learning and impairs extinction, biasing behavior toward persistent threat expectancy.
In the Dorsolateral striatal (DLS):
📈 ACh rises during threat prediction ⬇️ ACh drops during reward anticipation
This creates a clear bidirectional valence signature.
📈 ACh rises during threat prediction ⬇️ ACh drops during reward anticipation
This creates a clear bidirectional valence signature.
December 13, 2025 at 2:24 PM
In the Dorsolateral striatal (DLS):
📈 ACh rises during threat prediction ⬇️ ACh drops during reward anticipation
This creates a clear bidirectional valence signature.
📈 ACh rises during threat prediction ⬇️ ACh drops during reward anticipation
This creates a clear bidirectional valence signature.
Optogenetically increasing DLS ACh release accelerates threat learning and impairs extinction, biasing behavior toward persistent threat expectancy.
December 13, 2025 at 2:19 PM
Optogenetically increasing DLS ACh release accelerates threat learning and impairs extinction, biasing behavior toward persistent threat expectancy.
In the Dorsolateral striatal (DLS):
📈 ACh rises during threat prediction
⬇️ ACh drops during reward anticipation
This creates a clear bidirectional valence signature.
📈 ACh rises during threat prediction
⬇️ ACh drops during reward anticipation
This creates a clear bidirectional valence signature.
December 13, 2025 at 2:19 PM
In the Dorsolateral striatal (DLS):
📈 ACh rises during threat prediction
⬇️ ACh drops during reward anticipation
This creates a clear bidirectional valence signature.
📈 ACh rises during threat prediction
⬇️ ACh drops during reward anticipation
This creates a clear bidirectional valence signature.
Congrats Suzanne!
July 28, 2025 at 7:11 PM
Congrats Suzanne!
Congrats Kate and Jackie! Wohoo
February 20, 2025 at 2:45 PM
Congrats Kate and Jackie! Wohoo