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Gutmann Lab @gutmannlab.bsky.social · 3d

Excited to share our latest work in Neuro-Oncology Advances! 🥳 After comparing several potential therapies, we identified lamotrigine as a promising therapy for NF1 optic glioma, showing both tumor reduction and vision protection. Check out the work of our great team!

Head-to-head preclinical treatment design prioritizes promising therapies for neurofibromatosis type 1 optic glioma clinical translation

AbstractBackground. Authenticated preclinical brain tumor models provide unprecedented opportunities to evaluate next-generation treatments. However, some

academic.oup.com

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Gutmann Lab @gutmannlab.bsky.social · Sep 3

Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨

Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth

Anastasaki and colleagues establish a previously unknown glutamate growth dependency in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial molecular circuits present d...

www.cell.com

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Gutmann Lab @gutmannlab.bsky.social · Aug 4

We are so proud of Rasha and Rui's new paper! Their single cell reveals hidden diversity in CD8+ exhausted T cells across cancers, shedding light on why patients respond differently to immunotherapy and bringing us closer to more effective therapies. Don’t miss this exciting advance from our team!

Pan-cancer single cell transcriptomic clustering reveals heterogeneous CD8+ exhausted T cell populations with different immune checkpoint inhibitor responses

In most cancers, T lymphocytes comprise an essential cellular component of the non-neoplastic microenvironment, where they have the capacity to both suppress and support tumor growth. One specializ...

www.tandfonline.com

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Gutmann Lab @gutmannlab.bsky.social · Aug 1

We were thrilled to welcome Girl Scout Troop 222 to the lab this week! They explored science hands-on and got a glimpse of the work we do. Grateful for their curios minds and amazing energy—let’s keep inspiring the next generation of scientists! 🔬💫 #GirlsInSTEM #Troop222

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Gutmann Lab @gutmannlab.bsky.social · Jul 22

This past weekend we celebrated the 3rd Annual NF Family Day - a special time to honor our patients and families, build community, and have fun! From shaved ice and giant slides to visits from the St. Louis Fire and Police Department, we’re grateful for the support and another year moving forward.

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Gutmann Lab @gutmannlab.bsky.social · Jul 16

Today we celebrated two incredible members of the Gutmann lab. We'll miss Alex’s cooking tips and Talia’s humor, but we’re excited for all that lies ahead on their next adventures!

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Gutmann Lab @gutmannlab.bsky.social · Jun 20

Another year, another cherised lab photo! We are excited to see some colleagues embark on new journeys and we warmly welcome our newest members. What never changes is our commitment to a happy and collaborative research environment. #Researchteam #lablife

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Gutmann Lab @gutmannlab.bsky.social · Jun 4

This week we have said, "See you later" (never goodbye) to an incredible lab member! Chloe has brought joy and amazing work to the lab since her undergrad for more than 4 years. We wish her the best in NYC and her journey to med school.

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Gutmann Lab @gutmannlab.bsky.social · May 12

We are so happy to have our friends from Penny's Flight Foundation visit last week! It was wonderful sharing the exciting NF1 research currently happening in the lab. We're so grateful for their dedication to raising NF awareness, supporting patients, and championing research. #nf1 🦋

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Gutmann Lab @gutmannlab.bsky.social · Apr 22

Another celebration for the Gutmann Lab! Today, one of our newest undergrads, Paulina, makes her debut into the 20s. We are excited to have her for the summer and support her on her scientific journey next year. Happy Birthday Paulina! 🎉

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Gutmann Lab @gutmannlab.bsky.social · Apr 11

Today, we celebrate the journey of two amazing trainees in the lab. They have great things coming into their future, and we are equally sad and proud to see them go. Wherever their paths may take them, the Gutmann lab will always be their home.
Good luck, Laura and Xuanwei!

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Gutmann Lab @gutmannlab.bsky.social · Apr 9

The Gutmann Lab celebrates Giving Day at WashU Medical Campus!
In these hard times, our gratitude and donations are more important than ever. A community that supports and helps each other can handle anything that comes their way. #givingday