Drug Discovery and Development Centre
@h3dcentre.bsky.social
H3D is Africa’s first integrated holistic drug discovery and development centre. The Centre was founded at the University of Cape Town in April 2010 and pioneers world-class drug discovery in Africa.
📢 Now out in #ACSMedChemLett! Morake et al. show that phenylglycine-based benzoxaboroles show potent in vitro activity against the human #malaria parasite with good selectivity, solubility, metabolic stability and encouraging in vivo efficacy in mice 🐭 pubs.acs.org/doi/full/10....
A Novel Class of Orally Bioavailable Phenylglycine–Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action
A new class of benzoxaboroles with a phenylglycine appendage was found to display in vitro blood stage activity against the human malaria parasite Plasmodium falciparum (Pf). Structure–activity relati...
pubs.acs.org
December 17, 2025 at 10:38 AM
📢 Now out in #ACSMedChemLett! Morake et al. show that phenylglycine-based benzoxaboroles show potent in vitro activity against the human #malaria parasite with good selectivity, solubility, metabolic stability and encouraging in vivo efficacy in mice 🐭 pubs.acs.org/doi/full/10....
On the 1st of December, we marked #WorldAIDSDay2025 🔬💊
Launched in 2023, FLOWMAP uses cutting-edge flow chemistry to speed up, improve, and reduce the cost of producing active pharmaceutical ingredients (APIs), strengthening local drug-manufacturing capacity ⚙️🌍.
Launched in 2023, FLOWMAP uses cutting-edge flow chemistry to speed up, improve, and reduce the cost of producing active pharmaceutical ingredients (APIs), strengthening local drug-manufacturing capacity ⚙️🌍.
World AIDS Day 2025: Meet the researchers harnessing flow chemistry to increase ARV accessibility in South Africa
#WorldAIDSDay2025, we are proud to shine the spotlight on the Drug Discovery and Development Centre (H3D), University of Cape Town FLOWMAP (Flow manufacturing of Active pharmaceutics) project. Launche...
www.linkedin.com
December 8, 2025 at 10:07 AM
On the 1st of December, we marked #WorldAIDSDay2025 🔬💊
Launched in 2023, FLOWMAP uses cutting-edge flow chemistry to speed up, improve, and reduce the cost of producing active pharmaceutical ingredients (APIs), strengthening local drug-manufacturing capacity ⚙️🌍.
Launched in 2023, FLOWMAP uses cutting-edge flow chemistry to speed up, improve, and reduce the cost of producing active pharmaceutical ingredients (APIs), strengthening local drug-manufacturing capacity ⚙️🌍.
During World Antimicrobial Resistance #AMRAwarenessWeek 2025 (18–24 November), we highlighted the vital work of the Centre for Translational AMR Research (CTAR) — a collaboration between Drug Discovery and Development Centre (H3D), University of Cape Town and LifeArc in the UK. 💡🔬
AMR Awareness Week 2025: Meet the researchers tackling AMR and driving innovation from Africa to the World
TACKLING AMR WITH H3D’s CTAR TEAM In the wake of World Antimicrobial Resistance (AMR) Awareness Week 2025 last month (18 - 24 November), we’re shining the spotlight on the Centre for Translational AMR...
www.linkedin.com
December 8, 2025 at 10:02 AM
During World Antimicrobial Resistance #AMRAwarenessWeek 2025 (18–24 November), we highlighted the vital work of the Centre for Translational AMR Research (CTAR) — a collaboration between Drug Discovery and Development Centre (H3D), University of Cape Town and LifeArc in the UK. 💡🔬
🌟 From Inspired Visitor to H3D Scientist
A single visit to our 2023 Open Day sparked a passion that led one young attendee to join H3D — now proudly part of our scientific team as a Senior Research Scientist 👏😊.
A single visit to our 2023 Open Day sparked a passion that led one young attendee to join H3D — now proudly part of our scientific team as a Senior Research Scientist 👏😊.
December 8, 2025 at 9:59 AM
🌟 From Inspired Visitor to H3D Scientist
A single visit to our 2023 Open Day sparked a passion that led one young attendee to join H3D — now proudly part of our scientific team as a Senior Research Scientist 👏😊.
A single visit to our 2023 Open Day sparked a passion that led one young attendee to join H3D — now proudly part of our scientific team as a Senior Research Scientist 👏😊.
🌍💻💊 "Addressing infectious diseases in Africa by accelerating drug discovery through data science"—an important review article with @ersilia.io now out in @commsmed.nature.com and part of a broader writing project on the State of Data Science for Health in Africa: www.nature.com/articles/s43...
Addressing infectious diseases in Africa by accelerating drug discovery through data science - Communications Medicine
Turon et al. review the data science and research tool in relation to the heavy burden from infectious diseases, compounded by limited infrastructure in Africa. Data science is emerging as a powerful ...
www.nature.com
December 3, 2025 at 9:52 AM
🌍💻💊 "Addressing infectious diseases in Africa by accelerating drug discovery through data science"—an important review article with @ersilia.io now out in @commsmed.nature.com and part of a broader writing project on the State of Data Science for Health in Africa: www.nature.com/articles/s43...
Out now in @nature.com! 🌍💊 By harmonising regulations and embedding African genetic diversity into drug discovery, Mwila Mulubwa and Kelly Chibale explain how the new African Medicines Agency will ensure safer, more effective and equitable medicines for all Africans: www.nature.com/articles/d41...
Africa finally has its own drug-regulation agency — and it could transform the continent’s health
If it gets things right, the first major regulator of medicines to launch for 30 years could empower Africa to tackle African challenges around health and disease.
www.nature.com
November 10, 2025 at 12:40 PM
Out now in @nature.com! 🌍💊 By harmonising regulations and embedding African genetic diversity into drug discovery, Mwila Mulubwa and Kelly Chibale explain how the new African Medicines Agency will ensure safer, more effective and equitable medicines for all Africans: www.nature.com/articles/d41...
🌍 From 14 Sept–24 Oct 2025, Deborah Annor travelled from Ghana to H3D for a transformative research visit in organic synthesis & medicinal chemistry.🧬
🧪 “I gained hands-on experience, mentorship & skills that will shape my future in research.”
#CapacityBuilding #H3D #GhanaHub #ResearchVisitors
🧪 “I gained hands-on experience, mentorship & skills that will shape my future in research.”
#CapacityBuilding #H3D #GhanaHub #ResearchVisitors
November 5, 2025 at 10:55 AM
🌍 From 14 Sept–24 Oct 2025, Deborah Annor travelled from Ghana to H3D for a transformative research visit in organic synthesis & medicinal chemistry.🧬
🧪 “I gained hands-on experience, mentorship & skills that will shape my future in research.”
#CapacityBuilding #H3D #GhanaHub #ResearchVisitors
🧪 “I gained hands-on experience, mentorship & skills that will shape my future in research.”
#CapacityBuilding #H3D #GhanaHub #ResearchVisitors
🌟 Exciting opportunity at H3D, University of Cape Town!
We’re looking for a Procurement Officer to join the team from 1 December 2025. If you have experience in financial or purchasing administration and are ready to contribute to impactful science, this role could be for you.
We’re looking for a Procurement Officer to join the team from 1 December 2025. If you have experience in financial or purchasing administration and are ready to contribute to impactful science, this role could be for you.
November 3, 2025 at 12:47 PM
🌟 Exciting opportunity at H3D, University of Cape Town!
We’re looking for a Procurement Officer to join the team from 1 December 2025. If you have experience in financial or purchasing administration and are ready to contribute to impactful science, this role could be for you.
We’re looking for a Procurement Officer to join the team from 1 December 2025. If you have experience in financial or purchasing administration and are ready to contribute to impactful science, this role could be for you.
⏰ Final call to register!
Join us for the H3D Open Day 🧪
📅 Sat, 1 Nov | 🕙 10:00–14:00 | 📍UCT
Tour our labs, meet scientists & explore study paths in drug discovery.
🔗 Sign up now: forms.gle/vBbnfnAQFxcp...
#H3D #OpenDay #DrugDiscovery #UCT #FinalCall
Join us for the H3D Open Day 🧪
📅 Sat, 1 Nov | 🕙 10:00–14:00 | 📍UCT
Tour our labs, meet scientists & explore study paths in drug discovery.
🔗 Sign up now: forms.gle/vBbnfnAQFxcp...
#H3D #OpenDay #DrugDiscovery #UCT #FinalCall
October 30, 2025 at 10:18 AM
⏰ Final call to register!
Join us for the H3D Open Day 🧪
📅 Sat, 1 Nov | 🕙 10:00–14:00 | 📍UCT
Tour our labs, meet scientists & explore study paths in drug discovery.
🔗 Sign up now: forms.gle/vBbnfnAQFxcp...
#H3D #OpenDay #DrugDiscovery #UCT #FinalCall
Join us for the H3D Open Day 🧪
📅 Sat, 1 Nov | 🕙 10:00–14:00 | 📍UCT
Tour our labs, meet scientists & explore study paths in drug discovery.
🔗 Sign up now: forms.gle/vBbnfnAQFxcp...
#H3D #OpenDay #DrugDiscovery #UCT #FinalCall
🎉 Congratulations to Prof Kelly Chibale, Director of on your official induction as an International Member of the US National Academy of Medicine (NAM)!
A proud moment for African-led science 🌍 recognising your leadership in advancing drug discovery & global health innovation👏
A proud moment for African-led science 🌍 recognising your leadership in advancing drug discovery & global health innovation👏
October 30, 2025 at 10:17 AM
🎉 Congratulations to Prof Kelly Chibale, Director of on your official induction as an International Member of the US National Academy of Medicine (NAM)!
A proud moment for African-led science 🌍 recognising your leadership in advancing drug discovery & global health innovation👏
A proud moment for African-led science 🌍 recognising your leadership in advancing drug discovery & global health innovation👏
Africa's genetic diversity challenges effective drug treatments 💊 In #NatCommun, Turon and Mulubwa et al. present an AI-driven pipeline coupled to pharmacometrics to identify key drug-gene pairs and optimise doses for African populations, focusing on malaria and TB: www.nature.com/articles/s41...
Artificial intelligence coupled to pharmacometrics modelling to tailor malaria and tuberculosis treatment in Africa - Nature Communications
Authors analyzed malaria and tuberculosis drugs to create a pharmacometric model. They used an AI pipeline that prioritized pharmacogenetic drug-gene pairs with an emphasis on high variant frequency g...
www.nature.com
October 21, 2025 at 7:47 AM
Africa's genetic diversity challenges effective drug treatments 💊 In #NatCommun, Turon and Mulubwa et al. present an AI-driven pipeline coupled to pharmacometrics to identify key drug-gene pairs and optimise doses for African populations, focusing on malaria and TB: www.nature.com/articles/s41...
🔬 Ever wondered how new medicines are discovered?
Join us for the H3D Open Day 2025 at UCT!
👩🔬 Tour our labs
💡 Meet our scientists
🚀 Explore careers in drug discovery
📅 1 Nov 2025 | 🕙 10:00–14:00
📍 IDM, UCT
👉 Register: bit.ly/4nHd77W
#H3D #OpenDay #DrugDiscovery #ScienceCareers #UCT
Join us for the H3D Open Day 2025 at UCT!
👩🔬 Tour our labs
💡 Meet our scientists
🚀 Explore careers in drug discovery
📅 1 Nov 2025 | 🕙 10:00–14:00
📍 IDM, UCT
👉 Register: bit.ly/4nHd77W
#H3D #OpenDay #DrugDiscovery #ScienceCareers #UCT
October 16, 2025 at 10:19 AM
🔬 Ever wondered how new medicines are discovered?
Join us for the H3D Open Day 2025 at UCT!
👩🔬 Tour our labs
💡 Meet our scientists
🚀 Explore careers in drug discovery
📅 1 Nov 2025 | 🕙 10:00–14:00
📍 IDM, UCT
👉 Register: bit.ly/4nHd77W
#H3D #OpenDay #DrugDiscovery #ScienceCareers #UCT
Join us for the H3D Open Day 2025 at UCT!
👩🔬 Tour our labs
💡 Meet our scientists
🚀 Explore careers in drug discovery
📅 1 Nov 2025 | 🕙 10:00–14:00
📍 IDM, UCT
👉 Register: bit.ly/4nHd77W
#H3D #OpenDay #DrugDiscovery #ScienceCareers #UCT
Edward Odoi from the University of Ghana spent time at H3D, UCT (15 Sept–3 Oct 2025) to enhance his LC-MS skills and explore DMPK workflows. His first international trip was both inspiring and unforgettable! 🌍🔬 #H3D #ResearchExchange #DrugDiscovery #CapacityBuilding
October 13, 2025 at 12:52 PM
Edward Odoi from the University of Ghana spent time at H3D, UCT (15 Sept–3 Oct 2025) to enhance his LC-MS skills and explore DMPK workflows. His first international trip was both inspiring and unforgettable! 🌍🔬 #H3D #ResearchExchange #DrugDiscovery #CapacityBuilding
📢 Just out in #JMedChem! Dziwornu et al. describe the optimization of 2,8-diaryl-1,5-naphthyridines as #Plasmodium falciparum phosphatidylinositol 4‑kinase (PI4K) inhibitors with improved ADME profiles and in vivo efficacy 🐭 #malaria pubs.acs.org/doi/10.1021/...
Optimization of 2,8-Diaryl-1,5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy
Previously reported antimalarial Plasmodium phosphatidylinositol 4-kinase IIIβ 2,8-diaryl-1,5-naphthyridine inhibitors have shown suboptimal physicochemical and pharmacokinetic properties. A focused t...
pubs.acs.org
October 10, 2025 at 1:34 PM
📢 Just out in #JMedChem! Dziwornu et al. describe the optimization of 2,8-diaryl-1,5-naphthyridines as #Plasmodium falciparum phosphatidylinositol 4‑kinase (PI4K) inhibitors with improved ADME profiles and in vivo efficacy 🐭 #malaria pubs.acs.org/doi/10.1021/...
Join @h3dfoundation.bsky.social for the webinar series
📅 Thursday, 16 October 2025
⌚ 12PM (SAST)
👨🏽🔬 Kirandeep Kaur Samby Johnson & Johnson
💡 Screening Smarter: How Library Design Drives Discovery
Register and join here: lnkd.in/d8vWEGfg
📅 Thursday, 16 October 2025
⌚ 12PM (SAST)
👨🏽🔬 Kirandeep Kaur Samby Johnson & Johnson
💡 Screening Smarter: How Library Design Drives Discovery
Register and join here: lnkd.in/d8vWEGfg
October 10, 2025 at 12:08 PM
Join @h3dfoundation.bsky.social for the webinar series
📅 Thursday, 16 October 2025
⌚ 12PM (SAST)
👨🏽🔬 Kirandeep Kaur Samby Johnson & Johnson
💡 Screening Smarter: How Library Design Drives Discovery
Register and join here: lnkd.in/d8vWEGfg
📅 Thursday, 16 October 2025
⌚ 12PM (SAST)
👨🏽🔬 Kirandeep Kaur Samby Johnson & Johnson
💡 Screening Smarter: How Library Design Drives Discovery
Register and join here: lnkd.in/d8vWEGfg
Join @h3dfoundation.bsky.social for the webinar series
📅 Monday, 13 October
⌚ 12PM (SAST)
👨🏽🔬 Dr James Duffy Medicines for Malaria Venture
💡 The use of free drug concepts to guide compound optimisation in antimalarial drug discovery projects
Register and join here: lnkd.in/des-CzDB
📅 Monday, 13 October
⌚ 12PM (SAST)
👨🏽🔬 Dr James Duffy Medicines for Malaria Venture
💡 The use of free drug concepts to guide compound optimisation in antimalarial drug discovery projects
Register and join here: lnkd.in/des-CzDB
October 10, 2025 at 12:01 PM
Join @h3dfoundation.bsky.social for the webinar series
📅 Monday, 13 October
⌚ 12PM (SAST)
👨🏽🔬 Dr James Duffy Medicines for Malaria Venture
💡 The use of free drug concepts to guide compound optimisation in antimalarial drug discovery projects
Register and join here: lnkd.in/des-CzDB
📅 Monday, 13 October
⌚ 12PM (SAST)
👨🏽🔬 Dr James Duffy Medicines for Malaria Venture
💡 The use of free drug concepts to guide compound optimisation in antimalarial drug discovery projects
Register and join here: lnkd.in/des-CzDB
Celebrating #WorldPharmacistDay on the 25th of September 💊✨
From clinic to lab, Chief Investigator Mathew Njoroge shares his journey into #drugdiscovery, showing how pharmacists can shape new therapies & strengthen Africa’s research ecosystem🌍🧪
🔗 Read the full article here: lnkd.in/dtRi_xXd
From clinic to lab, Chief Investigator Mathew Njoroge shares his journey into #drugdiscovery, showing how pharmacists can shape new therapies & strengthen Africa’s research ecosystem🌍🧪
🔗 Read the full article here: lnkd.in/dtRi_xXd
From pharmacist to lab-based drug discovery scientist
In celebration of FIP World Pharmacist Day* (25 September) last week, we asked Dr Mathew Njoroge, chief investigator in the H3D Drug Metabolism and Pharmacokinetics (DMPK) team to share some insights ...
lnkd.in
October 1, 2025 at 9:06 AM
Celebrating #WorldPharmacistDay on the 25th of September 💊✨
From clinic to lab, Chief Investigator Mathew Njoroge shares his journey into #drugdiscovery, showing how pharmacists can shape new therapies & strengthen Africa’s research ecosystem🌍🧪
🔗 Read the full article here: lnkd.in/dtRi_xXd
From clinic to lab, Chief Investigator Mathew Njoroge shares his journey into #drugdiscovery, showing how pharmacists can shape new therapies & strengthen Africa’s research ecosystem🌍🧪
🔗 Read the full article here: lnkd.in/dtRi_xXd
Reposted by Drug Discovery and Development Centre
Introducing @h3dcentre.bsky.social! Focused on infectious diseases, they advance platforms and training to improve treatment across Africa. Through RAFIKI, H3D leads efforts to build compound- and data-sharing infrastructure for African drug discovery. #RAFIKI #DrugDiscovery #HorizonEU
September 23, 2025 at 11:46 AM
Introducing @h3dcentre.bsky.social! Focused on infectious diseases, they advance platforms and training to improve treatment across Africa. Through RAFIKI, H3D leads efforts to build compound- and data-sharing infrastructure for African drug discovery. #RAFIKI #DrugDiscovery #HorizonEU