Hadrien De Blander
@haddb.bsky.social
Reposted by Hadrien De Blander
🚀 New preprint! Meet ORIGAMI: Mapping cancer cell state heterogeneity and plasticity, predicting and steering therapy-induced trajectories to rationalize genotype-agnostic combination strategies with only two physical metrics (cell surface area and volume)
www.researchsquare.com/article/rs-8...
www.researchsquare.com/article/rs-8...
Simple cell geometry metrics reveal cancer cell diversity and plasticity and guide combination therapy
Intra-tumour heterogeneity (ITH) and cellular plasticity contribute to therapy resistance. Single-cell transcriptomics is the gold standard for assessing ITH, but this approach remains costly and slow...
www.researchsquare.com
January 9, 2026 at 4:40 PM
🚀 New preprint! Meet ORIGAMI: Mapping cancer cell state heterogeneity and plasticity, predicting and steering therapy-induced trajectories to rationalize genotype-agnostic combination strategies with only two physical metrics (cell surface area and volume)
www.researchsquare.com/article/rs-8...
www.researchsquare.com/article/rs-8...