A huge Thank You to all the collaborators who contributed to this fun project: Udi Qimron, @haitinlab.bsky.social, @bursteinlab.bsky.social, and congrats to the first author
@tridibmahata.bsky.social !

An open question remains - where will this be published? 😏

Great collaboration (as always)! And very funny story how HDX and native MS complement each other and reveal details about ions, substrates and mutations. We enjoyed this ride!

Excited to share our new paper in @febsj.bsky.social! 🎉
We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation
🔗 doi.org/10.1111/febs...
@peterslab1.bsky.social

W/ @moshegiladi @jvermaas @duncanboren
@TAUMedFaculty @SouraskyMedCtr @michiganstateu.bsky.social

We’re hiring PhD/MSc students! 🎓

How does a cytoplasmic enzyme make a membrane product? 🤔🧬

We found that a hydrophobic residue cluster helps the human cis-prenyltransferase feed its product into the ER membrane!

MD simulations + fluorescence = mechanistic insight 👇
🔗https://doi.org/10.1002/pro.70167

But your results are 🔥 as usual!

Whenever we get a bioRxiv alert, we'are always curious to see what it brings. This time, the timing couldn’t have been better - a very pleasant surprise! 😄
biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...

Combining crystallography, HDX-MS, MD simulations & network analysis, we've mapped critical allosteric networks controlling this essential enzyme.

💃🕺Happy to share a team effort to uncover the molecular "dance" behind human cis-prenyltransferase regulation!🔬🧬 @peterslab1.bsky.social @AlbGiacomello
#Biochemistry #StructuralBiology
@TAUMedFaculty @of_sagol biorxiv.org/content/10.1...

🥳

Thank you! A true pleasure, as always 😃

🚨New preprint alert! Wonder how a cancer-associated mutation in GGPPS impacts hexameric stoichiometry, substrate affinity, and product inhibition? Our results shed light on a novel regulatory mechanism in protein prenylation bit.ly/3ZR7w47 #MultipleMyeloma

1/ How do animals integrate different forms of learning? Our
@eyalrozenfeld.bsky.social new study in Science Advances
shows that active mechanisms prevent the co-formation of competing memories. Here’s what we found! 🧵👇
science.org/doi/10.1126/...

Long overlooked but significant!
This is the post-Cys specificity in post-proline cleaving enzymes like AnPEP or neprosin. Good work Zuza
and the team!🎉🔥
pubs.acs.org/doi/10.1021/...
(illustration IG:kuba_draws_science)

Hi!