Joe Hanly
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hanliconius.bsky.social
Joe Hanly
@hanliconius.bsky.social
interested in evolution, development and butterflies. Postdoc at GWU. #albinism. He/him 🏳️‍🌈
something something stupid Canadian wolf bird
February 2, 2026 at 9:22 PM
following on from that, when you use single cell data, you should bear in mind the different biases of snRNAseq vs scRNAseq - this lnc effect being one, also different expectations about intron/exon ratios in read mapping (which in my experience can be huge). 3/3
January 22, 2026 at 9:23 PM
So imho, we THOUGHT they were rarer than they are because of recovery bias. That gets exponentially more complex when you consider that a bunch of lncRNAs will be cell type specific, biasing it even further. /2
January 22, 2026 at 9:23 PM
One realisation I had while looking at the lncRNA ivory in single nucleus data: lncRNAs are generally nuclear, so in bulk RNAseq they are depleted because the nuclei make up a small volume of what gets extracted. In single nucleus RNAseq you will thus massively enrich any such transcripts. 1/
January 22, 2026 at 9:23 PM
i knew finnish people were tall, but wow
December 12, 2025 at 7:55 PM
How cool would it be to 3D print or sculpt the tree and set it in resin? It would be quite the centrepiece.
December 10, 2025 at 9:26 PM
Do share the author, this sounds like something that should go on my list.
December 6, 2025 at 3:14 AM
I'll be keeping my eyes peeled.
December 5, 2025 at 7:41 PM
I really liked the community science approach, it sounds like it must have been a lot of fun! Fingers crossed for more interesting mutants.
December 5, 2025 at 5:17 PM