No Sense 𝑒𝓉 𝒶𝓁.
@hans2sachs.bsky.social
Dear protein design community: Is there a benchmarked way to stabilize fusion proteins with the newer methods (ProteinMPNN)? Stabilize the whole structure or every fusion partner individually? Any experience would be welcome.
July 1, 2025 at 8:56 AM
Dear protein design community: Is there a benchmarked way to stabilize fusion proteins with the newer methods (ProteinMPNN)? Stabilize the whole structure or every fusion partner individually? Any experience would be welcome.
Reposted by No Sense 𝑒𝓉 𝒶𝓁.
A long long time ago, in a far away galaxy... the US used to tax the rich
May 23, 2025 at 8:19 PM
A long long time ago, in a far away galaxy... the US used to tax the rich
Reposted by No Sense 𝑒𝓉 𝒶𝓁.
Zolgensma’s $2M/dose price quickly became the standard for gene therapies.
Nine of them cost more than $2M. A tenth, approved in November, is predicted to run about $3.8M, just shy of the most expensive, which costs $4.25M/dose.
Nine of them cost more than $2M. A tenth, approved in November, is predicted to run about $3.8M, just shy of the most expensive, which costs $4.25M/dose.
What a $2 Million Per Dose Gene Therapy Reveals About Drug Pricing
Taxpayers and charities helped develop Zolgensma. Then it debuted at a record price, ushering in a new class of wildly expensive drugs. Its story upends the widely held conception that high prices…
www.propublica.org
May 13, 2025 at 3:30 AM
Zolgensma’s $2M/dose price quickly became the standard for gene therapies.
Nine of them cost more than $2M. A tenth, approved in November, is predicted to run about $3.8M, just shy of the most expensive, which costs $4.25M/dose.
Nine of them cost more than $2M. A tenth, approved in November, is predicted to run about $3.8M, just shy of the most expensive, which costs $4.25M/dose.
Reposted by No Sense 𝑒𝓉 𝒶𝓁.
This is Marco Rubio explaining how the USA promised to defend Ukraine forever if they got rid of their nuclear arsenal left after the Soviet Union fell.
This is why lil marco was sinking into the couch. He was hoping we wouldn’t find it…so don’t RT right now this very second.
This is why lil marco was sinking into the couch. He was hoping we wouldn’t find it…so don’t RT right now this very second.
March 2, 2025 at 4:55 PM
This is Marco Rubio explaining how the USA promised to defend Ukraine forever if they got rid of their nuclear arsenal left after the Soviet Union fell.
This is why lil marco was sinking into the couch. He was hoping we wouldn’t find it…so don’t RT right now this very second.
This is why lil marco was sinking into the couch. He was hoping we wouldn’t find it…so don’t RT right now this very second.
Reposted by No Sense 𝑒𝓉 𝒶𝓁.
“I don’t use those words lightly,” says Trump, refusing to call Putin a dictator, a week after calling Zelensky a dictator in a TRUTH SOCIAL post.
February 24, 2025 at 8:17 PM
“I don’t use those words lightly,” says Trump, refusing to call Putin a dictator, a week after calling Zelensky a dictator in a TRUTH SOCIAL post.
Reposted by No Sense 𝑒𝓉 𝒶𝓁.
This is what the government did with 120K+ Japanese Americans in 1942.
I know. I was there in those camps.
I know. I was there in those camps.
January 31, 2025 at 7:11 PM
This is what the government did with 120K+ Japanese Americans in 1942.
I know. I was there in those camps.
I know. I was there in those camps.
Reposted by No Sense 𝑒𝓉 𝒶𝓁.
Americans who hear Trump's evil expansionist speech and immediately say he's borrowing from Putin or the Nazis are clearly in denial about how much homegrown experience America has in such matters.
January 20, 2025 at 7:11 PM
Americans who hear Trump's evil expansionist speech and immediately say he's borrowing from Putin or the Nazis are clearly in denial about how much homegrown experience America has in such matters.
Reposted by No Sense 𝑒𝓉 𝒶𝓁.
Many industrially-important reactions (e.g. lipase-catalyzed biofuel production) involve substrates poorly soluble in water. How can we screen enzymes for these reactions? Samuel Thompson invented a new 'triple emulsion' platform for biphasic screening (1/n):
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
FACS‐Sortable Triple Emulsion Picoreactors for Screening Reactions in Biphasic Environments
Biphasic reactions can enhance reactions where the catalyst and substrate have different solvent preferences. This study optimizes triple emulsion picoreactors that encapsulate a biphasic solvent env...
onlinelibrary.wiley.com
December 13, 2024 at 1:54 AM
Many industrially-important reactions (e.g. lipase-catalyzed biofuel production) involve substrates poorly soluble in water. How can we screen enzymes for these reactions? Samuel Thompson invented a new 'triple emulsion' platform for biphasic screening (1/n):
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Finally, an academics wet dream has come true: end-to-end paper generation. doi.org/10.48550/arX...
December 11, 2024 at 8:21 AM
Finally, an academics wet dream has come true: end-to-end paper generation. doi.org/10.48550/arX...
Reposted by No Sense 𝑒𝓉 𝒶𝓁.
Love this insight on the AI tools Alphafold 3, Boltz and Chai-1 in antibody engineering (my day job). “It appears that these models well understand how antibodies fold, but not how they bind.” Thanks @btnaughton.bsky.social
Post: blog.booleanbiotech.com/alphafold3-b...
Post: blog.booleanbiotech.com/alphafold3-b...
December 1, 2024 at 4:44 AM
Love this insight on the AI tools Alphafold 3, Boltz and Chai-1 in antibody engineering (my day job). “It appears that these models well understand how antibodies fold, but not how they bind.” Thanks @btnaughton.bsky.social
Post: blog.booleanbiotech.com/alphafold3-b...
Post: blog.booleanbiotech.com/alphafold3-b...