The mechanism of STING NF-κB signaling has remained a mystery. An exciting new study from the Paludan lab now uses data throughout animal STING evolution to provide new answers – including isolating white blood cells from turtles and carp!

www.nature.com/articles/s41...

TWiV 1253: Harvard virology is not retreating
This Week in Virology - another great episode: www.microbe.tv/twiv/twiv-12...

Excited to share our new @natmicrobiol.nature.com paper revealing the most complete arenavirus glycoprotein complex (GPC) structures to date 🤩 www.nature.com/articles/s41...

“I Am Determined to Carry On This Vital Work”
David Knipe (knipelab.med.harvard.edu) studies how to prevent, combat, and make use of a virus that infects most people in the world:
magazine.hms.harvard.edu/articles/i-a...

Chan Lee @harperlabhms.bsky.social reports CASM-driven V-ATPase recruitment to lysosomes for acidification upon TRPML1 activation via DMXL1-RAVE loader. With Magdalene Moran(Caraway), Sophie Helaine lab, Joao Paulo, & HarperLab teams(HMS). Funds: Warren Alpert FND/NIH www.nature.com/articles/s41...

Brogan et al uncover a signaling pathway in which levels of the nucleotide second messenger c-di-AMP increase in response to defects in cell wall synthesis. This regulatory pathway decreases the cytoplasmic turgor pressure and protects the cell from lysis: www.nature.com/articles/s41...

Due to loss of research funding, we’ve had to terminate our Seminar Series -- a huge loss for our research community. We are happy to announce that through a private donor, we will be able to host some invited speakers’ again this fall. (1 of 2)

To support our research, click: micro.hms.harvard.edu/support-our-... or, to donate to the seminar series click on “contact us” at the bottom of the linked page. (2 of 2)

Joel Tan discovers a DNA molecular tripwire that guards against viral infection. New research from the Kranzusch (kranzuschlab.med.harvard.edu) and Jost (jostlab.org) labs in HMS Micro @nature.com www.nature.com/articles/s41...

Research from Renee Chang explains how viruses disrupt His-ADPR immune signaling. Kranzusch lab (kranzuschlab.med.harvard.edu), @soreklab.bsky.social, Tamulaitiene lab, @nature.com www.nature.com/articles/s41...