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Sheffield Hearing Group @hearingshef.bsky.social · 1d

A quick video on how we Immunolabel proteins in the organ of corti 😊🧪

Sheffield Hearing Group @hearingshef.bsky.social · 3d

Happy #MicroscopyMonday 🌟🔬 Todays photo comes from Ginny and shows pre and post synapses from inner hair cells. White stains the nucleus, red stains CtBP2, green stains Shank1 and blue stains GluR2🧪🐁

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Sheffield Hearing Group @hearingshef.bsky.social · 6d

Keep an eye out on our website to read more about each presentation and poster! 👀

sheffield.ac.uk/hearing

Hearing Research Group

Bringing together leading experts in physiology, genetics, developmental biology, stem cell biology and computational neuroscience to better understand the auditory system and develop therapeutic inte...

sheffield.ac.uk

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Sheffield Hearing Group @hearingshef.bsky.social · 6d

We've had a busy few weeks as we have returned from an amazing Inner Ear Biology conference in Tübingen!👂 It was inspiring to hear cutting-edge research and disseminate our own—Adam, Alice, and Char gave talks, while Ginny, Federico, Yan, and Andrea presented their latest work in poster sessions!🧑‍🔬🧪

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Reposted by Sheffield Hearing Group

Development, Regeneration and Neurophysiology @drn-sheffield.bsky.social · 21d

Ceriani et al. (2025). A machine-learning-based approach to predict early hallmarks of progressive hearing loss. Hearing Research 464, 109328.

doi.org/10.1016/j.he...

@hearingshef.bsky.social

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Sheffield Hearing Group @hearingshef.bsky.social · Sep 3

Today's spotlight comes from Hubert Lee and was published just last month. This clever paper shows that TMC1/2, the channels responsible for all hearing in mammals, can flip lipids between the membrane leaflets! The function is unknown, but it sure is interesting! www.biorxiv.org/content/10.1...

Sheffield Hearing Group @hearingshef.bsky.social · Sep 1

Happy #MicroscopyMonday everyone!🔬🌟 Today's image comes from Alice and it is a beautiful SEM (Scanning electron microscope) picture showing both the inner hair cells (at the bottom) and the three rows of outer hair cells (at the top)!🐀🧪

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Sheffield Hearing Group @hearingshef.bsky.social · Aug 18

Happy #MicroscopyMonday everyone! 🔬🌟Today's image is from Andrea, showing his first attempt at phalloidin staining of a 4 day-old zebrafish saccular macula - the main hearing organ of the fish.🐟 In the centre of the photo you can see the hair cells, with a few examples highlighted by white arrows!🧪

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Sheffield Hearing Group @hearingshef.bsky.social · Aug 12

Today's #TraceTuesday comes from Charlie! This trace was recorded towards the start of his PhD, showing spontaneous activity in neurons of the zebrafish lateral line. This spontaneous activity is a key feature during normal development of the zebrafish lateral line and the mammalian cochlea! 🐟🧪📈

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Sheffield Hearing Group @hearingshef.bsky.social · Aug 11

Happy #MicroscopyMonday everyone! 🔬Today’s image is from Alice. She injected this adult cochlea in vivo with an adeno-associated virus (AAV).🧬 We can see the AAV was able to transduce green fluorescent protein (GFP) into inner hair cells (brightly-labelled) and outer hair cells (dimly-labelled)🐀🧪

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Reposted by Sheffield Hearing Group

Joy Franco, PhD @engineeringjoy.bsky.social · Jun 6

Goodrich Lab manager and RA is making great progress with cochlea cleareing and imaging, getting closer and closer to single fiber resolution! 🥳 Perfect for #FluorescenceFriday

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Sheffield Hearing Group @hearingshef.bsky.social · Aug 1

JWST just released a new image of the red planet!
Just kidding, this is an image of the organ of Corti stained red that I've badly photoshopped 👩‍🚀 Have a great weekend all!

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Sheffield Hearing Group @hearingshef.bsky.social · Jul 28

Happy #MicroscopyMonday everyone!🌟🔬 Today's photos from Nic show a cross section of the retinal layers in mice eyes.🐀👀 Here we can see (from the bottom), the photoreceptor layer, the middle layer (containing bipolar, horizontal, and amacrine cells), and the ganglion cell layer!🧪

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Sheffield Hearing Group @hearingshef.bsky.social · Jul 25

Howdy, one of our PIs (Adam - me) was down in London earlier this week attending the @wellcometrust.bsky.social investigator meeting. It was great to see the breadth of what Wellcome fund and chat with other investigators (Primarily more senior). These are the only pics I got though as I was solo!

Sheffield Hearing Group @hearingshef.bsky.social · Jul 22

Today's #TraceTuesday comes from Nic, again! We have another trace from a retinal ganglion cell. 🦠 The small peak at the start is an artifact (Nic is still learning), but importantly, the big dip in the trace shows a large inward sodium current which is crucial for generating action potentials! 🧪📈

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Sheffield Hearing Group @hearingshef.bsky.social · Jul 21

Happy #MicroscopyMonday everyone!🌟🔬 Today we have a video from Ginny showing the electromotility in an outer hair cell of a 19 day old mouse.🐀 This process is the primary function of outer hair cells and it is key for hearing quiet sounds!🧪👂

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Sheffield Hearing Group @hearingshef.bsky.social · Jul 16

📖Howdy, today's paper spotlight comes from Xiayi Liao and was published this month. This (Exceptionally pretty) manuscript takes a detailed look at the addition of actin filaments to hair cell stereocilia; the tiny hairs that detect sounds within the inner ear!
pmc.ncbi.nlm.nih.gov/articles/PMC...

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Sheffield Hearing Group @hearingshef.bsky.social · Jul 14

Happy #MicroscopyMonday everyone!🔬 Today's image comes from Char!🌟 Here we can see a beautiful immunostaining of the mature spinal ganglion neurons from the apical region of the cochlea, where lower frequencies are detected, of a P25 mouse cochlea!🐀🧪

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Sheffield Hearing Group @hearingshef.bsky.social · Jul 11

We're excited to share that you can now watch Adam's recent @pintofscience.uk talk on demand via the University of Sheffield Player 🎥. Follow the link below to find out how the brain "talks back" to the ears! 🧠👂

🔗: player.sheffield.ac.uk/events/how-b...

#Pint25

How the Brain "Talks Back" to the Ears | The University of Sheffield Player

Discover how ears and brain communicate in hearing and why this research matters for hearing loss treatment.

player.sheffield.ac.uk

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Sheffield Hearing Group @hearingshef.bsky.social · Jul 2

Howdy! Today's paper spotlight comes from Chun Liang and was published in June. This paper shows that knocking out the ATP gated receptor P2X7 enhances hearing sensitivity but makes noise induced cochlea damage much worse! Adds info to those mysterious type II fibres 🔍 www.pnas.org/doi/10.1073/...

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Sheffield Hearing Group @hearingshef.bsky.social · Jul 1

Hey, thanks for the question! If you're meaning the shift in baseline after the big inward current, Sarah thinks this could be from ATP causing gap junction channels to close, which is what it seems like you're suggesting?

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Sheffield Hearing Group @hearingshef.bsky.social · Jul 1

Happy #TraceTuesday! Today's trace comes from Sarah, which shows a supporting cell being treated with adenosine triphosphate (ATP), the body's currency for energy. The dip in current represents a large inward current of ions that is triggered by the ATP treatment! 🧪📈

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Sheffield Hearing Group @hearingshef.bsky.social · Jun 30

The neuromast is part of the lateral line, an organ unique to fish and amphibians which is used to sense water displacement.

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Sheffield Hearing Group @hearingshef.bsky.social · Jun 30

Happy #MicroscopyMonday everyone!🔬🧪Today's video comes from Charlie and it shows the neuromast of a zebrafish!🐟 The bright flash represents activation of the hair cells (in red) and the neurons (in green) following stimulation from a waterjet.

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Reposted by Sheffield Hearing Group

Hearing Health Foundation @hearinghealthfn.bsky.social · Jun 26

“The concern nowadays is recreational noise and young people listening to music on headphones.” + Earwax “has an enzyme which can kill bacteria and viruses going into the ear, and it moisturises the skin as well.” www.theguardian.com/lifeandstyle... #earwax @theguardian.com #keeplistening

Get some earplugs – and never remove wax at home: 16 ways to protect your hearing, chosen by audiologists

Turn the volume down, don’t use cotton buds and get your hearing tested before it’s too late. Here’s what experts recommend to keep your ears healthy

www.theguardian.com

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