Special thanks to lead authors Danielle Bond and Sean Burnard and collaborators including @charles-debock.bsky.social, @mixomics.org and colleagues @hmriaustralia.bsky.social

These results show that AML therapies can increase epigenetic heterogeneity with implications for #cancer growth and treatment. By targeting the processes that help AML cells to re-initiate cancer growth, we may be able to delay AML progression.

Genes related to #cholesterol processes had increased expression in colonies formed after HMA exposure, regardless of the colony's methylation level. Targeting these processes with #statin co-treatment increased the efficacy of HMAs.

We show that some AML cells can evade the #epigenetic effects of these therapies and retain #DNAmethylation. We also found that HMA exposure alters transcription, even in highly-methylated cells.

I'm pleased to share that Leukemia have published our analysis of heterogeneous responses to hypomethylating agents #HMAs in Acute Myeloid Leukaemia #AML
www.nature.com/articles/s41...

We are looking for a talented postdoctoral bioinformatician @thedawsonlab.bsky.social to work with us on single cell multiomics incorporating lineage tracing and spatial technologies- we specifically want someone curious, fearless with a licence to innovate!! Come join us!!

@aepia.bsky.social members concerned about recent changes to US research agencies should consider following @epigeneticssociety.bsky.social and/or signing the declaration below.

Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org

We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇

embl.wd103.myworkdayjobs.com/en-US/EMBL/d...