findings suggest that obesity-driven microglial immunometabolic reprogramming persists despite TRF-induced weight loss and may contribute to obesogenic memory and weight regain after weight loss induced by dietary interventions.
www.sciencedirect.com/science/arti...

Time-restricted eating over 12 weeks can achieve greater improvement in insulin resistance compared to hypocaloric diet alone in MASLD subjects.
www.sciencedirect.com/science/arti...

Nature research paper: Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22

go.nature.com/4gPjgfA

A new very interesting study about the rhythm of O-GlcNAcylation by the Joanna Chiu's team
#Circadian

dx.plos.org/10.1371/jour...

• Right supTub volume underlies the comorbidity between schizophrenia and MS.
• Right supTub is a possible target for improving cognitive deficits in schizophrenia.
• MS may confound investigations of hypothalamic volume in schizophrenia.
www.sciencedirect.com/science/arti...

CoQ10 supplementation could mitigate oxidative damage and preserve mitochondrial integrity, but we are far from being able to claim that it can represents an effective therapeutic strategy to complement current pharmacological treatments in RTT patients.
www.sciencedirect.com/science/arti...

Hydrogen sulfide regulation in redox homeostasis and programmed cell death: mechanistic insights and implications in cancer
www.sciencedirect.com/science/arti...

Air #Pollution as a Key Risk Factor for #Alzheimer’s Disease: A Comprehensive Review
www.sciencedirect.com/science/arti...

Sex-specific associations between insomnia symptoms and mental health among Chinese young adults and the modified effect of CRY2 gene DNA methylation
link.springer.com/article/10.1...

#Parkinson’s disease and the #gut-brain connection: unveiling pathways, mechanisms and promising therapies
www.sciencedirect.com/science/arti...

The healing power of natural gifts: How the natural herbaceous plants targeting mitophagy can reverse diabetic complications
www.sciencedirect.com/science/arti...

Role of capsaicin, circadian clock genes, and TRPV1 in colorectal carcinogenesis: Lessons and future directions
www.sciencedirect.com/science/arti...

#Parkinson’s disease and the #gut-brain connection: unveiling pathways, mechanisms and promising therapies
www.sciencedirect.com/science/arti...

Circadian misalignment is a critical, yet often overlooked, contributor to cancer incidence and associated economic burdens. Public health strategies—such as regulating shift schedules, reducing LAN exposure, and promoting chronotherapy—are essential to mitigate these risks.

Mechanisms of disruption of the gut–brain axis by environmental endocrine disruptors
www.sciencedirect.com/science/arti...

Objective measures of blunted and fragmented 24 hour rest-activity rhythms were associated with adverse immune-metabolic outcomes. Stabilisation & amplitude-boosting of rest-activity rhythms may be particularly valuable targets for indicated prevention and early intervention of major mood disorders

Findings identify AA–EGCG as a multi-targeted nutritional strategy that mitigates glucocorticoid-induced muscle wasting by coordinating anabolic, catabolic, and mitochondrial pathways.
www.sciencedirect.com/science/arti...

This study provides genetic evidence that SGLT-2 inhibitors may reduce BD risk, partly modulated by Clostridium sporosphaeroides. Identified pathways (e.g., calcium signaling) and dysregulated genes highlight mecolic-immune interplay in bipolar disorder.

#Curcumin and Curcumin-loaded poly(caprolactone) nanoparticles restore #mitochondrial function in an in vitro #Parkinson’s disease model.
www.sciencedirect.com/science/arti...

Chronic stress-hypothalamus axis in #cancer processes.

Chronic #stress in #cancer development and progression

👇
www.sciencedirect.com/science/arti...
@erictopol.bsky.social

This work underscores mitophagy as a double-edged sword in lung inflammation and proposes precision interventions to balance mitochondrial quality control, offering novel avenues for inflammatory lung diseases.

Gut jet lag: how circadian rhythm disruption undermines the Chrono-Microbiota-Motility axis and induces functional constipation
www.frontiersin.org/journals/nut...