Herbert Wu
@herbertwu.bsky.social
100 followers 150 following 15 posts
Neuroscience Professor at Mount Sinai, into the science of squad goals. https://www.wulab.bio/
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herbertwu.bsky.social
Thanks so much for the generous support from @sinaibrain.bsky.social and the Glickenhaus Family!
sinaibrain.bsky.social
👏 A huge congratulations to Drs. @herbertwu.bsky.social and Sai Ma for receiving the 2025 Glickenhaus Research Scholar Award.🎉

Here, they discuss their work, "Neural Activity-Dependent Regulation of Transcriptomic Landscape: A Novel Approach to #Addiction". 👉 www.youtube.com/watch?v=nN9W...
2025 FBI Research Scholars - Herbert Wu and Sai Ma
YouTube video by Icahn School of Medicine
www.youtube.com
herbertwu.bsky.social
Thanks so much! Naive animals are untrained animals that don’t know how to cooperate
herbertwu.bsky.social
But an important part :)
herbertwu.bsky.social
Thanks Jen! Would appreciate any feedback!
herbertwu.bsky.social
Thanks Catherine! ❤️
herbertwu.bsky.social
This was a truly collaborative effort and will open new avenues to probe social cognition and collective behavior. Huge thanks to the amazing team who made this cooperation😁 possible! @esschaffer.bsky.social @nuttidanuttida.bsky.social @talmo.bsky.social @nan-mssm.bsky.social (5/5)
herbertwu.bsky.social
To uncover latent strategies, we built a multi-agent inverse RL (MAIRL) model with joint value decomposition. MAIRL infers individual goal and interaction maps that mirror asymmetric neural codes and are decodable from mPFC population activity, linking behavior, circuit, and computation (4/5)
herbertwu.bsky.social
The medial prefrontal cortex (mPFC) represents both trial-by-trial leadership dynamics and enduring social roles. It also encodes a role-based, egocentric “social value map” of partner's position that adapts to task demand. Disrupting mPFC impairs cooperation and shifts self–partner weighting (3/5)
herbertwu.bsky.social
Both leaders and followers integrate partner position into their decision-making, exerting asymmetric yet reciprocal influence. Forward multi-agent RL (MARL) shows simulated agents can learn the task and also develop stable leader–follower dynamics, suggesting social roles can self-organize (2/5)
herbertwu.bsky.social
Super excited to share the first cooperative foraging paradigm in freely interacting mouse pairs! Stable leader and follower roles emerge spontaneously and predict learning. Well-trained mice show stereotyped, role-specific “behavioral motifs” absent in naive animals (1/5)
doi.org/10.1101/2025...
herbertwu.bsky.social
Fascinating! The use of social gaze seems quite complicated in these cooperating marmosets
stevewcchang.bsky.social
Super excited to share this new collaborative work - marmosets use diverse and highly flexible strategies when they cooperate. These strategies are powerfully determined by both social factors (sex, dominance, familiarity) & individual partner identity.

www.cell.com/current-biol...
Diverse and flexible strategies enable successful cooperation in marmoset dyads
Meisner and Shi et al. show that common marmosets flexibly coordinate with partners using both gaze-dependent and rhythmic strategies. Cooperation depends on active social monitoring and is shaped by ...
www.cell.com
Reposted by Herbert Wu
dulaclab.bsky.social
Very excited to announce our latest paper uncovering circuit, cellular and molecular mechanisms underlying the formation and maintenance of social hierarchy, another terrific collaboration with @neurovenki.bsky.social, Vic Kapoor and Adam Nelson (not on bsky) www.sciencedirect.com/science/arti...