Hammo et al. show that a single dose of psilocybin rapidly and sustainably relieves both chronic pain and anxiodepressive-like behaviors in mice by restoring prefrontal activity through partial agonism at 5-HT2A and 5-HT1A receptors.

Scientific Reports - Quantum imaging with a photon counting camera

The hippocampus is essential for spatial and episodic memory, subserved by CA1 neurons. Hippocampal area CA2, which processes social memory, also m...

Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...

The mammalian hippocampus contains a cognitive map that represents an animal’s position in the environment [1][1] and generates offline “replay” [2][2],[3][3] for the purposes of recall [4][4], planni...

The mammalian hippocampus contains a cognitive map that represents an animal’s position in the environment [1][1] and generates offline “replay” [2][2],[3][3] for the purposes of recall [4][4], planni...

The authors identify reusable ‘dynamical motifs’ in artificial neural networks. These motifs enable flexible recombination of previously learned capabilities, promoting modular, compositional computation and rapid transfer learning. This discovery sheds light on the fundamental building blocks of intelligent behavior.

Neurons that respond emergently to illusory contours drive pattern completion in V1. Pattern completion in lower cortical areas may therefore mediate perceptual inference by selectively reinforcing activity patterns that match prior expectations.

The coincidence time window is the maximal temporal interval that allows two stimuli to be associated in Pavlovian learning. However, its neuronal mechanism remains unclear. Zeng et al. identify a ser...

Zhang et al. develop a system that reads activity from individual neurons in real time and uses holographic light patterns to control specific neurons in mice, enabling automated, all-optical experime...

Using two-photon optogenetics, electrical recordings and sparse signal reconstruction, the authors demonstrate in vivo synaptic connectivity mapping in the mouse visual cortex.

Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...

Neuromorphic model of hippocampus place cells using an oscillatory interference technique for hardware implementation, Zhaoqi, Chen, Nasrallah, Alia, Alemohammad, Milad, Furuta, Masanori, Etienne-Cumm...

We introduce Paper2Agent, an automated framework that converts research papers into AI agents. Paper2Agent transforms research output from passive artifacts into active systems that can accelerate dow...

Landry et al. show that short-term high-fat diet reduces hippocampal glucose availability, driving CCK-IN hyperactivity and memory deficits. Normalizing aberrant PKM2 or CCK-IN activity subsequently p...

A major challenge for modern AI is to learn to understand the world and learn to act largely by observation. This paper explores a self-supervised approach that combines internet-scale video data with...

The Asian Conference on Machine Learning (ACML) is an international conference in the area of machine learning. It aims at providing a leading international forum for researchers in Machine Learning and related fields to share their new ideas and achievements.