Join us for the final TPD webinar of 2024 on 12/19.

@fleurmferguson.bsky.social & Eric Wang - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC"

Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"

Orgchem or biochem folks! How do you manage an enzyme-catalyzed synthesis when your starting material crashes out upon mixing with your protein?

It works well on a small scale, but scaling up becomes tricky. Any tips or tricks?