@idmadisonkurpiel.bsky.social
Similarly to what was discussed in the ID2 course regarding the POET trial, there are several limitations noted in this study that may complicate the selection and reliance on oral therapy for IE. #PITT_IDFall25
Does oral antibiotic switching therapy show similar efficacy to intravenous administration for treating infective endocarditis?
✅ Just Accepted
🔗 https://bit.ly/3JNCW7x
✅ Just Accepted
🔗 https://bit.ly/3JNCW7x
November 9, 2025 at 2:54 PM
Similarly to what was discussed in the ID2 course regarding the POET trial, there are several limitations noted in this study that may complicate the selection and reliance on oral therapy for IE. #PITT_IDFall25
Susceptibility of measles virus to WHO hand rubs, oral and surface disinfectants
✅ Just Accepted
#IDSky
🔗 https://bit.ly/47m4OaP
✅ Just Accepted
#IDSky
🔗 https://bit.ly/47m4OaP
November 2, 2025 at 2:30 PM
Foreign Combatants Wounded in Ukraine colonized by Extensively Drug-Resistant organisms: A Potential Source of Global Dissemination
✅ Just Accepted
#IDSky
🔗 https://bit.ly/42YYG74
✅ Just Accepted
#IDSky
🔗 https://bit.ly/42YYG74
November 2, 2025 at 2:25 PM
Trichomonas vaginalis Among Cisgender Women Taking Doxycycline Postexposure Prophylaxis
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3W4CLr3
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3W4CLr3
October 23, 2025 at 3:48 PM
October 23, 2025 at 3:47 PM
As this drug is one of the last-line options used for MDR infections, it is concerning that resistance mechanisms, including tigecycline specific efflux pumps and inactivating enzymes are becoming more prevalent. #PITT_IDFall25
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
The emergence of tet(X) variants highlight challenges for the global genomic surveillance of tigecycline resistance
Tigecycline is one of the last-line antimicrobials against infections caused by multidrug-resistant
bacteria. Recent articles published in The Lancet Microbe have highlighted the spread
of tigecycline...
www.thelancet.com
October 23, 2025 at 3:47 PM
As this drug is one of the last-line options used for MDR infections, it is concerning that resistance mechanisms, including tigecycline specific efflux pumps and inactivating enzymes are becoming more prevalent. #PITT_IDFall25
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Very important diagnostic information that can be assessed for in many pharmacy settings, and especially as we head into the Winter season! #PITT_IDFall25
Community-acquired pneumonia is the leading infectious cause of morbidity and mortality globally.
Yet, there are several challenges associated with diagnosis, treatment, and long-term management of Community-acquired pneumonia.
Find out more in a new Seminar: tinyurl.com/hd2fwz7n
Yet, there are several challenges associated with diagnosis, treatment, and long-term management of Community-acquired pneumonia.
Find out more in a new Seminar: tinyurl.com/hd2fwz7n
October 23, 2025 at 3:39 PM
Very important diagnostic information that can be assessed for in many pharmacy settings, and especially as we head into the Winter season! #PITT_IDFall25
While the study found that cefiderocol is very much useful in gram-negative MDR bacteremia, questions remain on the safety of the drug itself and its efficacy in CRE. #PITT_IDFall25
Trial finds cefiderocol isn't superior to standard antibiotics for bloodstream infections
Cefiderocol was found to be noninferior for gram-negative bloodstream infections, but more evidence is needed in patients with carbapenem-resistant infections.
www.cidrap.umn.edu/a...
Cefiderocol was found to be noninferior for gram-negative bloodstream infections, but more evidence is needed in patients with carbapenem-resistant infections.
www.cidrap.umn.edu/a...
October 12, 2025 at 12:38 PM
While the study found that cefiderocol is very much useful in gram-negative MDR bacteremia, questions remain on the safety of the drug itself and its efficacy in CRE. #PITT_IDFall25
Interesting to learn how PGx unveils differences in drug response through pathways other than CYP enzymes or HLA genes! #PITT_IDFall25
NAT2 polymorphisms and Antituberculosis-Induced Hepatotoxicity in Thai People Living with HIV: Insights from a Pharmacogenetic?Pharmacokinetic Cohort Study
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
NAT2 polymorphisms and Antituberculosis-Induced Hepatotoxicity in Thai People Living with HIV: Insights from a Pharmacogenetic–Pharmacokinetic Cohort Study
NAT2 slow acetylator phenotypes, especially *6A/*6A and *7B/*7B genotypes, significantly increase the risk of antituberculosis-induced hepatotoxicity in Th
bit.ly
October 12, 2025 at 12:31 PM
Interesting to learn how PGx unveils differences in drug response through pathways other than CYP enzymes or HLA genes! #PITT_IDFall25
Identifying gaps in tuberculosis preventive care for non-U.S.-born persons at community health clinics in the United States
✅ Just Accepted
🔗 https://bit.ly/42TvGxh
✅ Just Accepted
🔗 https://bit.ly/42TvGxh
October 5, 2025 at 12:43 PM
This article helps to identify some of the mechanisms that contribute to the high recurrence rate of C. difficile infections. #PITT_IDFall25
Insights on recurrent and sequential Clostridioides difficile infections from genomic surveillance in Minnesota, USA, 2019-2021
✅ Just Accepted
#IDSky
🔗 https://bit.ly/46zgcB0
✅ Just Accepted
#IDSky
🔗 https://bit.ly/46zgcB0
October 5, 2025 at 12:41 PM
This article helps to identify some of the mechanisms that contribute to the high recurrence rate of C. difficile infections. #PITT_IDFall25
Investigating Azithromycin Activity Against ESBL-Producing Escherichia coli Under Physiologically Relevant Conditions
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3KAnbAM
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3KAnbAM
September 28, 2025 at 1:57 PM
This stresses the importance of pharmacist counseling for antibiotics that have a greater incidence of C. diff occurring! #PITT_IDFall25
Survey finds low but rising public awareness of C diff
Among 1,000 US respondents, 54% said they weren't familiar with C difficile infection, down from 60% in a 2021 survey.
www.cidrap.umn.edu/c...
Among 1,000 US respondents, 54% said they weren't familiar with C difficile infection, down from 60% in a 2021 survey.
www.cidrap.umn.edu/c...
September 28, 2025 at 1:54 PM
This stresses the importance of pharmacist counseling for antibiotics that have a greater incidence of C. diff occurring! #PITT_IDFall25
A system like this could help to improve individual patient adherence along with reducing the overuse/inappropriate use of antimicrobials. #PITT_IDFall25
The Take 5 Campaign: Effects of an Intervention to Promote Five-Day Durations of Antibiotic Therapy for Common Infections in Urgent Care
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4mmS1dC
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4mmS1dC
September 21, 2025 at 2:25 PM
A system like this could help to improve individual patient adherence along with reducing the overuse/inappropriate use of antimicrobials. #PITT_IDFall25
Great to see Pennsylvania a part of this! #PITT_IDFall25
Northeast states form alliance to make public health guidance as Vermont, DC ensure COVID vaccine access
7 states & New York City have been collaborating since early 2025 but formally announced the collaborative yesterday
www.cidrap.umn.edu/c...
Photo: Self Magazine/Flickr cc
7 states & New York City have been collaborating since early 2025 but formally announced the collaborative yesterday
www.cidrap.umn.edu/c...
Photo: Self Magazine/Flickr cc
September 21, 2025 at 2:06 PM
Great to see Pennsylvania a part of this! #PITT_IDFall25
Fatal Adverse Event After VLA1553 Chikungunya Vaccination in an Elderly Patient: A Case Report from Reunion Island
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Fatal Adverse Event After VLA1553 Chikungunya Vaccination in an Elderly Patient: A Case Report from Reunion Island
We report the first fatal adverse event plausibly linked to the live-attenuated chikungunya vaccine (VLA1553) in an elderly patient.
bit.ly
September 14, 2025 at 7:57 PM
This highlights the role that pharmacists can play in public and healthcare education in order to continue the safe and appropriate use of antimicrobials. #PITT_IDFall25
Study highlights gaps between antibiotic knowledge, appropriate prescribing
A study in India finds that even among providers who have knowledge about appropriate antibiotic use, 62% inappropriately prescribed antibiotics for viral child diarrhea.
www.cidrap.umn.edu/a...
A study in India finds that even among providers who have knowledge about appropriate antibiotic use, 62% inappropriately prescribed antibiotics for viral child diarrhea.
www.cidrap.umn.edu/a...
September 14, 2025 at 7:56 PM
This highlights the role that pharmacists can play in public and healthcare education in order to continue the safe and appropriate use of antimicrobials. #PITT_IDFall25
As the new school year begins, it will be interesting to see if the incidence of preventable diseases trends upwards. #PITT_ID25
New measles cases reported in Virginia, New Jersey
The two cases add to what is the worst year for measles in the United States since the disease was declared eliminated in 2000.
The two cases add to what is the worst year for measles in the United States since the disease was declared eliminated in 2000.
New measles cases reported in Virginia, New Jersey
The two cases add to what is the worst year for measles in the United States since the disease was declared eliminated in 2000.
www.cidrap.umn.edu
September 7, 2025 at 10:12 PM
As the new school year begins, it will be interesting to see if the incidence of preventable diseases trends upwards. #PITT_ID25
This article helps to emphasize the need for the US to continue nationwide efforts to educate, test and treat for STIs in pregnancy to reduce the incidence of transmission, especially with the availability of resources in our country. #PITT_ID25
September 7, 2025 at 10:05 PM
This article helps to emphasize the need for the US to continue nationwide efforts to educate, test and treat for STIs in pregnancy to reduce the incidence of transmission, especially with the availability of resources in our country. #PITT_ID25
Establishing the Optimal Ceftriaxone MIC for Predicting ESBL Production in Bloodstream Infections
✅ Just Accepted
https://bit.ly/426MyQH
✅ Just Accepted
https://bit.ly/426MyQH
Establishing the Optimal Ceftriaxone MIC for Predicting ESBL Production in Bloodstream Infections
Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) hydrolyze most β-lactam antibiotics, with the general exception of carbapenems.
bit.ly
September 2, 2025 at 4:16 PM
Interesting to see another example of a situation in which oral, outpatient antibiotics can be used to reduce the use of IV agents and length of hospital admissions. #PITT_ID25
September 2, 2025 at 4:11 PM
Interesting to see another example of a situation in which oral, outpatient antibiotics can be used to reduce the use of IV agents and length of hospital admissions. #PITT_ID25
Many rural areas, such as Appalachia, may have a lower overall prevalence of injection drug users than more population dense urban settings, but the lack of quality healthcare access impedes harm reduction measures and can result in more significant infectious complications. #PITT_ID25
Injection-related infections and self-treatment practices among people who inject drugs in rural Appalachia
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Injection-related infections and self-treatment practices among people who inject drugs in rural Appalachia
In this study of self-reported serious injection-related infections (SIRI) among people who inject drugs in rural Appalachia (n=463), 50% reported reusing syringes/needles, 70.6% ever had an injection-site abscess, and 44.4% of those with a recent abscess took non-prescribed antibiotics.
doi.org
April 13, 2025 at 2:09 PM
Many rural areas, such as Appalachia, may have a lower overall prevalence of injection drug users than more population dense urban settings, but the lack of quality healthcare access impedes harm reduction measures and can result in more significant infectious complications. #PITT_ID25
FMGX inhibits glycosylphosphatidylinositol anchor protein 1, which inhibits input of mannoproteins into the fungal cell wall, and may provide a new treatment of invasive Aspergillus. However 43% of the study group died, which raises concerns for safety of this investigational drug. #PITT_ID25
Fosmanogepix for the Treatment of Invasive Mold Diseases Caused by Aspergillus Species and Rare Molds: A Phase 2, Open-Label Study (AEGIS)
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Fosmanogepix for the Treatment of Invasive Mold Diseases Caused by Aspergillus Species and Rare Molds: A Phase 2, Open-Label Study (AEGIS)
This Phase 2 study evaluated efficacy and safety of FMGX treatment in invasive mold diseases (IMDs) by Aspergillus spp. and rare molds in adults with limited treatment options.
doi.org
April 13, 2025 at 1:52 PM
FMGX inhibits glycosylphosphatidylinositol anchor protein 1, which inhibits input of mannoproteins into the fungal cell wall, and may provide a new treatment of invasive Aspergillus. However 43% of the study group died, which raises concerns for safety of this investigational drug. #PITT_ID25
Curious to see if this has any correlation or connection with the rising number of deaths due to CDI that has been seen within the past years . #PITT_ID25
Study highlights hidden spread of C diff in ICUs
Analysis of daily samples from patients, room surfaces, and healthcare worker hands found spread of C diff was more than 3-fold higher than in studies relying only on patient samples.
www.cidrap.umn.edu/c...
Analysis of daily samples from patients, room surfaces, and healthcare worker hands found spread of C diff was more than 3-fold higher than in studies relying only on patient samples.
www.cidrap.umn.edu/c...
April 7, 2025 at 11:18 PM
Curious to see if this has any correlation or connection with the rising number of deaths due to CDI that has been seen within the past years . #PITT_ID25