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Reposted by Idoyaga Lab

Andrew S. MacDonald @profandrewmac.bsky.social · 20d

Beautiful data from Franca Ronchese, all the way from @malaghan.bsky.social in New Zealand, about generation and function of subsets of skin #DendriticCells in #allergic responses #EMDS2025

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Reposted by Idoyaga Lab

Andrew S. MacDonald @profandrewmac.bsky.social · 22d

A fascinating education in #LangerhansCell biology and function from Clare Bennett, as well as a closing advert for the 18th International #DendriticCell symposium in San Diego next year #EMDS2025 #DC2026

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Reposted by Idoyaga Lab

Journal of Experimental Medicine @jem.org · 26d

Tadepalli, Clements et al. @idoyagalab.bsky.social reveal that CD301b⁺ monocyte-derived dendritic cells mediate resistance to #radiotherapy. rupress.org/jem/article/...

📘 #Macrophages and #DendriticCells in Health and Disease 👉 rupress.org/jem/collecti...

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Idoyaga Lab @idoyagalab.bsky.social · Sep 4

Thanks Judith!

Idoyaga Lab @idoyagalab.bsky.social · Sep 3

Thank you so much Hiu!! 🙏

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Idoyaga Lab @idoyagalab.bsky.social · Sep 3

Thanks 🙏 Michael!!

Idoyaga Lab @idoyagalab.bsky.social · Sep 3

Gracias Miguel! 🙏

Idoyaga Lab @idoyagalab.bsky.social · Sep 3

Thank you Maria!!

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Idoyaga Lab @idoyagalab.bsky.social · Sep 3

Thank you Caetano! 🙏

Idoyaga Lab @idoyagalab.bsky.social · Sep 2

Thanks Amy!! 🙏

Idoyaga Lab @idoyagalab.bsky.social · Sep 2

Our paper made the cover of Nature Immunology’s September issue! 🎉
Aren’t dendritic cells beautiful? 😍
SEM shows pDCs as they switch identity into cDC2-like cells.
Congrats to the whole team! 👏
🔗 www.nature.com/ni/volumes/2...

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Reposted by Idoyaga Lab

Rebeca Arroyo @rebecaarroyo.bsky.social · Aug 16

Thanks to @idoyagalab.bsky.social for supporting my postdoctoral work and making this paper possible. Super excited to show how pDCs regulate their antigen presentation function switching to cDC2!

Idoyaga Lab @idoyagalab.bsky.social · Aug 15

🚨 Our latest paper is out in @natimmunol.nature.com ! 🧵
Plasmacytoid dendritic cells (pDCs) — the immune system’s IFN-I powerhouses — can change their identity!
Congrats to @rebecaarroyo.bsky.social, our team & collaborators 👏👏
🔗 www.nature.com/articles/s41...

TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells - Nature Immunology

Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the authors show how...

www.nature.com

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Idoyaga Lab @idoyagalab.bsky.social · Aug 15

Delighted to share that our @natimmunol.nature.com paper has now a fantastic News & Views
🔗 www.nature.com/articles/s41...
Thank you, @esegura-lab.bsky.social, for a clear and thoughtful summary 🙏

And thanks to our 3 amazing reviewers: your feedback made this work stronger. Peer review at its best!

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Idoyaga Lab @idoyagalab.bsky.social · Aug 15

Why it matters:
This pDC → cDC plasticity could let us tune immunity — boosting antiviral defenses or damping harmful inflammation in autoimmunity.

A new lever for immune therapy?

Idoyaga Lab @idoyagalab.bsky.social · Aug 15

This isn’t just in a petri dish:
We saw it in human skin inflammation, wounds, and even healthy aging.
pDC plasticity happens in vivo — actively shaping immune responses in health & disease.

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Idoyaga Lab @idoyagalab.bsky.social · Aug 15

Using single-cell omics + functional assays, we saw activated pDCs lose IFN-I machinery & gain cDC type 2 (cDC2) traits— a full fate switch.

Two key regulators:

TNF → is the switch push
IFN-I → is the restrain

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Idoyaga Lab @idoyagalab.bsky.social · Aug 15

pDCs are famous for cranking out type I interferon to fight viruses.
Conventional DCs (cDCs) present antigens to activate T cells.
But here’s the puzzle: why are pDCs part of the dendritic cell family at all? 🤔
Turns out, they can change teams.

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Idoyaga Lab @idoyagalab.bsky.social · Aug 15

🚨 Our latest paper is out in @natimmunol.nature.com ! 🧵
Plasmacytoid dendritic cells (pDCs) — the immune system’s IFN-I powerhouses — can change their identity!
Congrats to @rebecaarroyo.bsky.social, our team & collaborators 👏👏
🔗 www.nature.com/articles/s41...

TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells - Nature Immunology

Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the authors show how...

www.nature.com

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Reposted by Idoyaga Lab

klechevskylab.bsky.social @klechevskylab.bsky.social · Apr 21

Langerhans Cells, Dendritic Cell and #skinimmunology lovers❤️ #LC2025 registration is NOW OPEN! Meet us in St. Louis @washu_pathology, Sep. 3-5, 2025, Amazing program! Intimate and collaborative discussions on breakthrough discoveries! register today at langerhans.org

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Idoyaga Lab @idoyagalab.bsky.social · Apr 1

Our latest @jem.org paper is out!
Radiotherapy induces GM-CSF in melanoma, driving monocytes to become regulatory monocyte-derived dendritic cells (moDCs)—traced with Ms4a3-TdTomato mice!
Huge shoutout to @Sirimuvva Tadepalli + @Derek Clements for leading this!

Journal of Experimental Medicine @jem.org · Mar 27

#Radiotherapy not only kills tumors but also shapes #immunity. @idoyagalab.bsky.social reveal that in radioresistant tumors, clinically relevant radiotherapy induces GM-CSF secretion, driving immunosuppressive monocyte-derived dendritic cells and regulatory T cells. rupress.org/jem/article/...

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Idoyaga Lab @idoyagalab.bsky.social · Dec 2

✋🙏! Thanks!

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Reposted by Idoyaga Lab

Shalin H. Naik @shalinhnaik.bsky.social · Nov 19

We are ramping up our attempts to get DC1 immunotherapy into the clinic for colorectal and lung cancer. Here me talk about why DC1s are the right choice, and how
WEHI and PeterMacCC will get it to clinical trial within 2 yrs. Start ~13 min in. podcasts.apple.com/au/podcast/v...

VAXXED: Game on, with BASE and WEHI

Podcast Episode · Phase III · 19/11/2024 · 26m

podcasts.apple.com

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Idoyaga Lab @idoyagalab.bsky.social · Nov 18

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Idoyaga Lab @idoyagalab.bsky.social · Nov 17

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Idoyaga Lab @idoyagalab.bsky.social · Nov 17

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