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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · 6d

Excited to be speaking at #NYBCI25 this weekend, alongside so many leaders in #Neurotech and #BCI.

It’s rare to have such diverse perspectives in one place, and I’m looking forward to the dialogue that emerges from bringing them together to advance the field.

www.nybci.com/event/2886b6...

2025 New York BCI Symposium

https://www.nybci.com/event/2886b64d-65fd-42dd-856c-57ff4a467388/program"

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · 9d

I left the 2025 @onemindorg.bsky.social music festival feeling inspired by the advances in mental health research and awareness that, together, are cracking the future of care wide open.

Proud to be part of this community alongside peers like @maryamshanechi.bsky.social & @claudialugo.bsky.social!

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Reposted by Ignacio Saez, PhD

The Friedman Brain Institute @sinaibrain.bsky.social · 22d

❤️Thank you to all of Mount Sinai’s past, present and future #PostdoctoralScholars whose hard work and dedication play a vital role in advancing biomedical research. Here, we celebrate the #SchillerLab’s Dr. @paruljain.bsky.social! #NPAW2025 Learn More about her work👉 www.teenmiso.org/post/intervi...

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · 21d

I'm looking forward to seeing how these findings complement our work in human models & how, together, these approaches can move us toward a unified understanding of the neural mechanisms that shape our decisions.

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · 21d

Big congrats to @intlbrainlab.bsky.social on two groundbreaking new papers!

Based on the most comprehensive map of mouse brain activity yet, their findings show how decision-making is both widely distributed and shaped by past experience.

Read more: www.thetransmitter.org/decision-mak...

Everything everywhere all at once: Decision-making signals engage entire brain

The findings, gleaned from the most comprehensive map yet of brain activity during decision-making in mice, show that the process is even more distributed than previously thought.

www.thetransmitter.org

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · Sep 2

What I’m reading 👉📚 A powerful & personal piece by
@jacobrobinson.bsky.social (CEO @motifneuro.bsky.social) on how brain-computer interfaces could transform mental health.

Honest, bold & inspiring. I encourage folks to read & subscribe. brainjacob.substack.com

#BCIs #BrainComputerInterface

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · Aug 19

Data from participants with treatment-resistant depression is revolutionizing our understanding of network disorders 🧠💻

Listen to a great discussion between @crozell.bsky.social and @braininspired.bsky.social on the potential of neuromodulation as a treatment for psychiatric disorders! 🎙️

The Transmitter @thetransmitter.bsky.social · Aug 13

In the latest episode of Brain Inspired, ‪@crozell.bsky.social describes how his team is combining deep brain stimulation and explainable artificial intelligence to develop tools to help people with treatment-resistant depression.‬

www.thetransmitter.org/brain-inspir...

#neuroskyence

Chris Rozell on brain stimulation and AI to treat depression

Rozell and his colleagues, using deep brain stimulation and explainable AI, have developed tools to help people with treatment-resistant depression.

www.thetransmitter.org

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Reposted by Ignacio Saez, PhD

The Friedman Brain Institute @sinaibrain.bsky.social · Aug 13

NOT TO MISS! On Sept 22, 2025, Dr. Peter Rudebeck & The Lipschultz Center for Cognitive Neuroscience invite cognitive neuroscientists to a free symposium showcasing cutting-edge research being conducted across NYC & the surrounding area. Learn More | RSVP friedmanbrain.icahn.mssm.edu/lipschultz-s...

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · Aug 6

Need reality check on where brain-computer interface technology stands today? 🧠💻

This insightful conversation from @wired.com offers an accessible and grounded introduction to the field, covering what's possible now and some of the challenges that lie ahead.

WIRED @wired.com · Jul 24

On this episode of "Uncanny Valley," we dive into the heated race between two companies to build a commercial brain-computer interface. www.wired.com/story/uncann...

The Very Real Case for Brain-Computer Implants

On this episode of "Uncanny Valley," we dive into the heated race between two companies to build a commercial brain-computer interface.

www.wired.com

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Reposted by Ignacio Saez, PhD

Nature Human Behaviour @nathumbehav.nature.com · Jul 21

This study establishes how aperiodic activity, a ubiquitous signal linked to neural noise, develops in localized brain regions and illuminates the development of prefrontal control during adolescence in the development of attention and memory.

The development of aperiodic neural activity in the human brain - Nature Human Behaviour

This study establishes how aperiodic activity, a ubiquitous signal linked to neural noise, develops in localized brain regions and illuminates the development of prefrontal control during adolescence in the development of attention and memory.

www.nature.com

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · Jul 21

How is prefrontal neural activity refined as we age?

Out today in @nathumbehav.nature.com‬! This study, from Elizabeth Johnson, uncovers how subtle changes in neural 'noise' impact our attention, memory, and cognition through development.

Proud to have contributed!

www.nature.com/articles/s41...

The development of aperiodic neural activity in the human brain header

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · Jul 9

As we step into summer, we’re taking a moment to reflect on an amazing past year and offer a warm welcome aboard to our new lab members, @emanuelmcoleman.bsky.social‬ and Henry Asher! We’re thrilled to have you join the Saez Lab team and look forward to an exciting year ahead.

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · Jun 11

Huge news for Paradromics! 🎉 Their first human implant is a major milestone. Excited to see the Connexus Brain-Computer Interface enter clinical trials, bringing us closer to restoring motor and speech function for people with disabilities. Great coverage from @ashleycapoot.cnbc.com

CNBC @cnbc.com · Jun 2

It’s a major milestone for the nearly 10-year-old startup, as it marks the beginning of its next chapter as a clinical-stage company.

Neuralink competitor Paradromics completes first human implant

The procedure took place at the University of Michigan with a patient who was already undergoing neurosurgery to treat epilepsy.

cnb.cx

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · Jun 2

Looking forward to speaking at #DES2025! I’ll be sharing insights on how brain computer interfaces are helping us advance cognitive neuroscience.

www.des-show.com/agenda-sessi...

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · May 30

What an incredible milestone! 🎉 Proud to celebrate Dr. Arianna Neal Davis, the Saez Lab's first Ph.D. graduate! 🎓

After an exceptional defense, we wish her all the best as she embarks on completing medical school 🥼 So proud to have co-supervised this trailblazer with
@xiaosigu.bsky.social

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · May 22

Thanks to @psypost.bsky.social for the thoughtful coverage of our work exploring the neural basis of human decision-making!

Explore these findings in further detail in our paper: www.jneurosci.org/content/45/1...

Learn more about our work: thesaezlab.com

PsyPost @psypost.bsky.social · May 19

Surprisingly widespread brain activity supports economic decision-making, new study finds

A new study using direct brain recordings reveals that human economic decision-making is not localized to a single brain region. Instead, multiple areas work together, with high-frequency activity encoding risk, reward probability, and the final choice itself.

www.psypost.org

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · May 19

Had a great conversation hosted by Dr. Josh Bederson about how our lab is revolutionizing our understanding of the brain with intraoperative recordings.

🎞️ Watch to learn how our lab is advancing translational & cognitive neurosciences & neurotechnology: vimeo.com/1079556842/7...

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · May 15

Unlocking the brain's potential 🔐

Our research investigates how activities like meditation influence human brain activity, revealing pathways for noninvasive neuromodulation.

Thanks to Yoga Journal for highlighting this work.

www.yogajournal.com/meditation/n...

What the Latest Research in Neuroscience Tells Us About Meditation

An exploration of the neuroscience of meditation, including recent research as well as future potential for its application.

www.yogajournal.com

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · May 12

We suggest that low-frequency OFC oscillations in humans reflect risk-taking attitudes & stimulation can alter risk behaviors, informing new therapies for disorders associated with risky behavior.

Congrats Alexandra Skular, Dr. Lu Jin & Dr. Jacqueline Overton on their great work!

(11/11)

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · May 12

As a consequence, when delta-theta coherence is slow, or disrupted through stimulation, patients revert to the safe bet, which does not require strong integration of multiple computations ($10 is $10!). Stimulating OFC causes risk aversion!

(10/11)

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · May 12

How does this work?

We propose that delta-theta coherence serves to integrate reward computations (risk, win probability, etc.) present in high-frequency activity through CFC. Thus, personal preferences (low freqs) and external risk (in high freqs) are integrated.

(9/11)

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · May 12

OFC stimulation was also associated with faster reaction times.

This suggests that stimulation effects on risk preference are distinct from impulsivity, which is often associated with faster reactions.

(8/11)

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · May 12

Strikingly, disruption of delta-theta oscillations via targeted OFC stimulation modulated risk preferences.

Stimulation results in increased risk-averse behavior, which is less dependent on functional integration of multiple reward computations.

(7/11)

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · May 12

The oscillatory phase of delta-theta OFC activity modulates high-frequency activity (gamma/high-gamma), which we previously showed encodes the level of risk presented, via phase-amplitude cross-frequency coupling (CFC).

(6/11)

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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · May 12

Individuals with stronger synchronization of low-frequency (delta-theta) oscillatory activity within the OFC showed riskier behavior.

This link was location & frequency specific, suggesting that coordinated timing of OFC activity plays a central role in decision making.

(5/11)

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