Irune Guerra
@iguerrasj.bsky.social
🌲🌿🔬🌺🌊🌌 | Postdoctoral fellow @ NINDS/NIH | Neurobiologist | views are my own
Reposted by Irune Guerra
Sharing our latest work, an ALS-related KCNQ2 splice variant that yields a dead channel (no K+ permeability), aggregates in neurons and causes intrinsic hyperexcitability.
Thanks to co-firsts Kelly and Peter, Kiskinis, Eggan and Fratta groups and others.
www.nature.com/articles/s41...
Thanks to co-firsts Kelly and Peter, Kiskinis, Eggan and Fratta groups and others.
www.nature.com/articles/s41...
TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD - Nature Neuroscience
TDP-43 dysfunction in ALS/FTD causes faulty splicing of the KCNQ2 ion channel, leading to toxic protein buildup, neuron hyperactivity and a potential new biomarker and treatment target using RNA-based...
www.nature.com
November 4, 2025 at 3:09 AM
Sharing our latest work, an ALS-related KCNQ2 splice variant that yields a dead channel (no K+ permeability), aggregates in neurons and causes intrinsic hyperexcitability.
Thanks to co-firsts Kelly and Peter, Kiskinis, Eggan and Fratta groups and others.
www.nature.com/articles/s41...
Thanks to co-firsts Kelly and Peter, Kiskinis, Eggan and Fratta groups and others.
www.nature.com/articles/s41...
Reposted by Irune Guerra
Proud to present our new paper in @natmetabolism.nature.com
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY
Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY
Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
LinkedIn
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lnkd.in
September 22, 2025 at 11:02 AM
Proud to present our new paper in @natmetabolism.nature.com
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY
Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY
Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).