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Immunorad @immunorad.bsky.social · 3d

Proteotoxic stress response drives T cell exhaustion and immune evasion

Nature - A proteotoxic stress response specific to exhausted T cells, governed by AKT signaling and accompanied by increased protein translation, represents a mechanistic vulnerability and a new...

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Immunorad @immunorad.bsky.social · 3d

📰 #UpdateYourRefs !
⚡ New breakthrough study revealing that a unique #proteotoxic #stress response (Tex-PSR) is a key mechanistic driver of T cell #exhaustion and #immune evasion in cancer. Targeting this proteostasis pathway represents a promising new approach for enhancing cancer #immunotherapy.

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Immunorad @immunorad.bsky.social · 19d

“Nuclear medicine at the era of AI and precision medicine” from Désirée Deandreis (Gustave Roussy).
Key insights in the LinkedIn post ➡️ www.linkedin.com/feed/update/...

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Immunorad @immunorad.bsky.social · 19d

“Biomarker-guided selection for FLASH and low-dose immunomodulation” from Dr Fernanda Herrera (CHUV Lausanne University Hospital).
Key insights on the LinkedIn post ➡️ www.linkedin.com/feed/update/...

✨ Biomarker-guided selection for FLASH and low-dose immunomodulation (LDRT) Dr. Fernanda Herrera shared new insights on how low-dose radiotherapy (LDRT) and FLASH RT may reshape immunotherapy… | Immun...

✨ Biomarker-guided selection for FLASH and low-dose immunomodulation (LDRT) Dr. Fernanda Herrera shared new insights on how low-dose radiotherapy (LDRT) and FLASH RT may reshape immunotherapy strategi...

www.linkedin.com

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Immunorad @immunorad.bsky.social · 19d

⏱️ Live Feed: Pr Laurence Zitvogel (Gustave Roussy, France) talked about the #metabolism at the cross road between gut #commensalism and
cancer #immunosurveillance.

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Immunorad @immunorad.bsky.social · 19d

"Interventional radiology for cancer immunotherapy: past, present, and future” from Pr Lambros Tselikas (Gustave Roussy).
Key insights on the LinkedIn post ➡️ www.linkedin.com/feed/update/...

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Immunorad @immunorad.bsky.social · 19d

⏱️ Live Feed: Pr eric deutsch (Gustave Roussy, France) talked about translational frontiers and clinical opportunities of #immunologically fitted #radiotherapy.

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Immunorad @immunorad.bsky.social · 19d

“The use of PET for assessing on-treatment changes in radiolabeled anti-PD-L1 uptake during chemoradiotherapy in NSCLC” from Pr Idris Bahce.
Key insights on LinkedIn ➡️ www.linkedin.com/feed/update/...

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Immunorad @immunorad.bsky.social · 19d

"“Tumor immune microenvironment delineates the evolutionary trajectories of distinct phenotypes of locoregionally-advanced EBV-positive nasopharyngeal carcinoma” from Pr Melvin LK Chua (National Cancer Center Singapore).
Key insights on LinkedIn➡️ www.linkedin.com/feed/update/...

🌐 Tumor immune microenvironment as a guide in EBV⁺ nasopharyngeal carcinoma To close the Tumor Microenvironment session at ImmunoRad 2025, Prof. Melvin L.K. Chua (Singapore) explored how the tumor… | ...

🌐 Tumor immune microenvironment as a guide in EBV⁺ nasopharyngeal carcinoma To close the Tumor Microenvironment session at ImmunoRad 2025, Prof. Melvin L.K. Chua (Singapore) explored how the tumor imm...

www.linkedin.com

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Immunorad @immunorad.bsky.social · 19d

⏱️ Live Feed: Dr. Maria E. Rodriguez Ruiz (University of Navarra, Spain) talked about the exploitation of #FAP-inducibility and cross-priming requirements in #radioimmunotherapy.

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Immunorad @immunorad.bsky.social · 20d

"NNMT inhibition in cancer-associated fibroblasts restores antitumor immunity" from Dr Janna Heide.
Key insights in the LinkedIn post➡️ www.linkedin.com/feed/update/...

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Immunorad @immunorad.bsky.social · 20d

⏱️ Live Feed: Pr Ignacio Melero (Clínica Universidad de Navarra, Spain) talked about low dose and #neutrophil extracellular traps (#NETs).

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Immunorad @immunorad.bsky.social · 20d

“Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma” from Jérôme Galon (Cordeliers Research Center) during the "Next Generation Immunotherapy" session.
Key insights on LinkedIn ➡️ www.linkedin.com/feed/update/...

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Immunorad @immunorad.bsky.social · 20d

Great talk as usual @johannajoyce.bsky.social ! 👍

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Immunorad @immunorad.bsky.social · 20d

⏱️ Live Feed: Pr Kevin Harrington (ICR, UK) presented a comprehensive talk about #STING agonism during adjuvant #immunotherapy for #radiocurable cancers.

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Immunorad @immunorad.bsky.social · 20d

Second talk of the “DNA Damage” session: “Epigenetic, Transcriptomic and genetic analyses of HR+/HER2- primary and metastatic breast cancer reveals heterogeneous mechanisms of endocrine therapy resistance” from Dr Sergey Nikolaev (Gustave Roussy).
Key insights ➡️ www.linkedin.com/feed/update/...

🧬 Unraveling endocrine therapy resistance in HR⁺/HER2⁻ breast cancer In the DNA Damage session, Dr. Sergey Nikolaev (Gustave Roussy) presented multi-omic insights into why HR⁺/HER2⁻ breast cancers… | ...

🧬 Unraveling endocrine therapy resistance in HR⁺/HER2⁻ breast cancer In the DNA Damage session, Dr. Sergey Nikolaev (Gustave Roussy) presented multi-omic insights into why HR⁺/HER2⁻ breast cancers dev...

www.linkedin.com

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Immunorad @immunorad.bsky.social · 20d

Last talk of the “Immunosuppression” session at Immunorad 2025: “Microbiota-primed fibroblasts contribute to radiotherapy-induced lung metastasis progression” by Dr Andras Piffko from University Medical Center (Hamburg-Eppendorf). Key highlights on the LinkedIn post➡️ www.linkedin.com/feed/update/...

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Immunorad @immunorad.bsky.social · 20d

⏱️ Live Feed: Dr. Monica Olcina (University of Oxford, UK) discussed how targeting the #complement receptor #C5aR1 could enhance #radiotherapy efficacy in #immunosuppressive tumor #microenvironments.

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Immunorad @immunorad.bsky.social · 20d

"Unraveling the complexity of cancer ecosystems following therapeutic intervention" from Pr Johanna Joyce in the "Immunosuppression" session.
Highlights of the talk on Linkedin➡️ www.linkedin.com/feed/update/...

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Immunorad @immunorad.bsky.social · 20d

⏱️ Live Feed: Dr. Yungan TAO (Gustave Roussy, France) delivered a comprehensive update on the evolving role of #immunotherapy combined with hashtag#radiotherapy in head and neck squamous cell carcinoma (#HNSCC).

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Immunorad @immunorad.bsky.social · 20d

⏱️ Live Feed: Great presentation from Anne-Gaëlle Goubet (University of Geneva, Switzerland)

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Immunorad @immunorad.bsky.social · 21d

"Heterogeneous intratumor irradiation: a new partner for immunotherapy" from Dr. Michele Mondini. Key insights from the talk on LinkedIn ➡️ www.linkedin.com/feed/update/...

During the second talk of the “Radiation dose, modalities and resistance” session, Dr. Michele Mondini presented exciting preclinical insights into SFRT — moving beyond the traditional dogma of… | Imm...

During the second talk of the “Radiation dose, modalities and resistance” session, Dr. Michele Mondini presented exciting preclinical insights into SFRT — moving beyond the traditional dogma of unifor...

www.linkedin.com

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Immunorad @immunorad.bsky.social · 21d

⏱️ Live Feed: #Neuroendocrine Control of Cancer #Immunosurveillance, featuring Guido Kroemer.
Spotlight on #ACBP / #DBI, a newly identified #gerogene / #geroprotein with age-dependent expression

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Immunorad @immunorad.bsky.social · 21d

🦠"Diagnosis of gut dysbiosis and relevance for clinical outcome" from Dr Lisa Derosa (Gustave Roussy, France). Key highlights on Linkedin ➡️https://www.linkedin.com/feed/update/urn:li:activity:7374072113168801792

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Immunorad @immunorad.bsky.social · 21d

🔬 Reprogramming the TME to Overcome Radioresistance Key takeaways from Pr. Tim Illidge (Manchester Cancer Research Centre) at #ImmunoRad2025
--> www.linkedin.com/feed/update/...

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