Institute of Neurodegenerative Diseases
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imn-bordeaux.bsky.social
Institute of Neurodegenerative Diseases
@imn-bordeaux.bsky.social
IMN combines fundamental, preclinical and clinical research in neurosciences with the aim of develop new therapeutic approaches for neurodegenerative diseases 🧠
L'ensemble de l'IMN a pu se retrouver autour d'un joli repas de Noël et vous souhaite d'excellentes fêtes de fin d'année ! 🎄🎅

📸 @arnaudrodriguez.bsky.social
December 18, 2025 at 2:35 PM
📰 "Targeting pain with deep brain stimulation: Insights into the thalamus and associated structures", published in Deep Brain Stimulation

✒️ Rabia Bouali-Benazzouz, Pascal Fossat, Abdelhamid Benazzouz

📍 For more : www.dbsjournal.com/article/S294...
Targeting pain with deep brain stimulation: Insights into the thalamus and associated structures
Chronic pain is a major public health issue, and despite advances in understanding its pathophysiology, current treatments remain insufficient, significantly affecting patients' quality of life. Exist...
www.dbsjournal.com
December 15, 2025 at 1:52 PM
📰 "Alzheimer’s Tau seeds-induced pathology enhances hippocampal extracellular diffusion", published in communications biology.

✒️ J. Estaún Panzano, A. Lovisotto, C. Mazzocco, C.Piva, M. Darricau, V.Planche, B. Dehay, E. Bezard and al.

📍 For more : www.nature.com/articles/s42...
Alzheimer’s Tau seeds-induced pathology enhances hippocampal extracellular diffusion - Communications Biology
Quantum dot single-particle tracking in live mouse brain tissue was used to study extracellular diffusion in a Tau model. Tau aggregation and inflammation increase extracellular diffusion which may fa...
www.nature.com
December 15, 2025 at 1:47 PM
New article about how the basal ganglia and cortex work together to learn and adapt complex movements 🧠⚙️
📰 "Reward-driven adaptation of movements requires strong recurrent basal ganglia–cortical loops", published in PNAS
✒️ A. Leblois, T. Boraud and D. Hansel
📍 For more : www.pnas.org/doi/10.1073/...
Reward-driven adaptation of movements requires strong recurrent basal ganglia–cortical loops | PNAS
The basal ganglia (BG) are a collection of subcortical nuclei involved in motor control, sensorimotor integration, and procedural learning. They pl...
www.pnas.org
December 12, 2025 at 10:38 AM
New article !
📰 "Animal models of ADHD: diversity and validity" 🐭

✒️ An article by Sarah Bou Sader Nehme, Sandra Sánchez Sarasúa de la Bárcena, Mari-Carmen Medrano, Marc Landry and al. published in Aspet journals, Pharmacological Reviews.

📍 For more : pharmrev.aspetjournals.org/article/S003...
Animal models of ADHD: diversity and validity
Attention-deficit/hyperactivity disorder (ADHD) is one of the most widespread neurodevelopmental disorders globally, marked by chronic symptoms of inattention and/or hyperactivity-impulsivity. Its mul...
pharmrev.aspetjournals.org
December 5, 2025 at 9:24 AM
Congratulations to Eduarda Gervini Zampieri Centeno, winner of the 2025 Open Science Thesis Award 🏆

The award recognizes theses in which open science practices have contributed to the quality of the scientific work.

📍 For more : imn.u-bordeaux.fr/en/2025/12/0...
Eduarda Centeno, winner of the 2025 Open Science Thesis Award × IMN
Institut des Maladies Neurodégénératives
imn.u-bordeaux.fr
December 5, 2025 at 8:14 AM
Alexandra Dupic, interne en neurologie, a eu l'occasion d'interviewer Pierre Burbaud, neurologue et professeur des universités - praticien hospitalier à l'IMN sur l'impact qu'ont les habitudes sur le développement cérébral 🧠

📍 Interview : reseauprosante.fr/articles/sho...
Interview du professeur Pierre Burbaud
Je suis neurologue, PU-PH, avec un parcours un peu atypique.
reseauprosante.fr
December 1, 2025 at 1:36 PM
📰 Phenotypic characterization of an Atp13a2 knockout rat model of Parkinson’s disease
✒️ By R Kinet, ML Arotçarena, E Doudnikoff, A. Lovisotto, ML Thiolat, N Dutheil, C Mazzocco, F Georges, E Bezard, PO Fernagut, B Dehay and al. published in NPJ Parkinson Disease
www.nature.com/articles/s41...
Phenotypic characterization of an Atp13a2 knockout rat model of Parkinson’s disease - npj Parkinson's Disease
npj Parkinson's Disease - Phenotypic characterization of an Atp13a2 knockout rat model of Parkinson’s disease
www.nature.com
November 19, 2025 at 12:47 PM
@cedricbrun.bsky.social and Thomas Boraud, coorganise with Serge Ahmed and Thomas pradeux, "The Impact of Philosophical Thinking on Today's Neuroscience"
📅 November 24th-25th, University of Bordeaux, IBGC
🎟️ Mandatory Registration
📍 Details and registration : philinbiomed.cnrs.fr/event/philos...
Conference: The Impact of philosophical thinking on today’s neuroscience – philinbiomed
Please feel free to circulate this announcement to all the persons who may be interested.
philinbiomed.cnrs.fr
November 13, 2025 at 1:14 PM
Reposted by Institute of Neurodegenerative Diseases
🔬 Des chercheurs, notamment de l’Institut des maladies neurodégénératives @imn-bordeaux.bsky.social , montrent qu’un modèle de fibrille d’alpha-synucléine fabriqué in vitro peut se répliquer et se propager dans le cerveau de souris (1/2)
Quand une fibrille synthétique s’auto-réplique dans le cerveau | CNRS Biologie
L’atrophie multisystématisée (MSA) est une maladie neurodégénérative rare et incurable marquée par la présence d’inclusions intracellulaires faites de f
www.insb.cnrs.fr
November 12, 2025 at 5:00 PM
Reposted by Institute of Neurodegenerative Diseases
OFFRE D'EMPLOI - Assistant·e Ingénieure en expérimentation animale
💫

Le PIV-EXPE recrute pour rejoindre son équipe engagée et passionnée, au service de la recherche en neurosciences fondamentales et translationnelles.

👉 Pour plus d'infos : imn.u-bordeaux.fr/.../assistan...
Assistant·e Ingénieure en expérimentation animale × IMN
Institut des Maladies Neurodégénératives
imn.u-bordeaux.fr
October 31, 2025 at 8:48 AM
A l'occasion de la Semaine de l'Open Access et de la Science Ouverte 2025, des webinaires en ligne sont organisés toute la semaine !
👥 Ils visent à valoriser et promouvoir les pratiques de recherche ouverte, accessible et collaborative.

www.bordeaux-neurocampus.fr/event/semain...
Semaine de l’Open Access et de la Science Ouverte 2025 - Bordeaux Neurocampus
A l'initiative de l'Université de Bordeaux
www.bordeaux-neurocampus.fr
October 21, 2025 at 1:19 PM
Hack1robo 2025 - retour sur évènement 🤖
Le hackathon qui fusionne IA, Robotique, Sciences Cognitives et Arts 🎨🤖🧠

@sudouest.fr était présent: www.sudouest.fr/gironde/bord...

Bravo au comité d'organisation pour cette superbe édition : X. Hinaut, L. Fontaine, Y. Bendi-Ouis, C. Mercier et A. Gillig 🙌
« C’est un marathon de la bidouille » : à Bordeaux, quand l’IA rencontre les arts et la robotique
Ce dimanche, à la Station Marne, neuf équipes présenteront leurs prototypes élaborés durant 48 heures. Des projets qui peuvent parfois aller bien au-delà de la bonne idée
www.sudouest.fr
October 20, 2025 at 1:49 PM
🗣️ Soirée AVC: prévention, science et échanges grand public

Qu’est-ce qu’un AVC? À quoi sert la recherche en imagerie pour la prévention des AVC?

📅 29/10, 18h
📍 Café des Sciences, Cap Sciences
🎤 @micheltds.bsky.social, S. Olindo, R. Benazzouz et C. Sanchez-Cortes
👉 imn.u-bordeaux.fr/en/events/so...
Soirée AVC : prévention, science et échanges – Mini-talks grand public × IMN
Institut des Maladies Neurodégénératives
imn.u-bordeaux.fr
October 20, 2025 at 12:52 PM
Les Entretiens Alzheimer 2025 🧩
Que vous soyez aidants, patients ou curieux, venez en apprendre + sur la maladie d'Alzheimer
🗓️ Lundi 13 octobre, 14h-17h
📍 Palais de la Bourse, Bordeaux
🗣️ @vincentplanche.bsky.social et autres professionnels de santé

www.bordeaux-neurocampus.fr/event/les-en...
Les entretiens alzheimer - 8ème édition, Bordeaux - Bordeaux Neurocampus
Venez assister à la 8ème édition des entretiens Alzheimer
www.bordeaux-neurocampus.fr
October 8, 2025 at 12:16 PM
New comment in @nature.com by @nicolasrougier.bsky.social and al.:
Stop treating code like an afterthought: record, share and value it.
Scientists, research institutions, funders, libraries and publishers must all improve software practices.

👉 For more details : www.nature.com/articles/d41...
Stop treating code like an afterthought: record, share and value it
Scientists, research institutions, funders, libraries and publishers must all improve software practices.
www.nature.com
October 7, 2025 at 12:10 PM
How can we improve the differential diagnosis of neurodegenerative diseases with AI-enhanced MRI analyses? How can we make the interpretation of results easier for clinicians?
📰 New article from @vincentplanche.bsky.social and al.

For more details : alzres.biomedcentral.com/articles/10....
petBrain: a new pipeline for amyloid, Tau tangles and neurodegeneration quantification using PET and MRI - Alzheimer's Research & Therapy
Introduction Quantification of amyloid plaques (A), neurofibrillary tangles (T2), and neurodegeneration (N) using PET and MRI is critical for Alzheimer’s disease (AD) diagnosis and prognosis. Existing pipelines face limitations regarding processing time, tracer variability handling, and multimodal integration. Methods We developed petBrain, a novel end-to-end processing pipeline for amyloid-PET, tau-PET, and structural MRI. It leverages deep learning-based segmentation, standardized biomarker quantification (Centiloid, CenTauR, HAVAs), and simultaneous estimation of A, T2, and N biomarkers. It is implemented in a web-based format, requiring no local computational infrastructure and software usage knowledge. Results petBrain provides reliable, rapid quantification with results comparable to existing pipelines for A and T2, showing strong concordance with data processed in ADNI databases. The staging and quantification of A/T2/N by petBrain demonstrated good agreements with CSF/plasma biomarkers, clinical status and cognitive performance. Discussion petBrain represents a powerful open platform for standardized AD biomarker analysis, facilitating clinical research applications.
alzres.biomedcentral.com
October 2, 2025 at 1:29 PM
Reposted by Institute of Neurodegenerative Diseases
🏆 Pascal Fossat @imn-bordeaux.bsky.social , est lauréat 2025 du fonds franco-canadien pour travailler sur les récepteurs de la sérotonine spinale comme nouvelles cibles thérapeutiques potentielles pour la douleur :
Pascal Fossat, lauréat du fonds franco-canadien pour la recherche - Bordeaux Neurocampus
Financement de l'ambassade de France au Canada
www.bordeaux-neurocampus.fr
September 11, 2025 at 4:00 PM
🎉 NEW TEAM IN THE LAB!
@agnesnadjar.bsky.social set up her own team - Neuroimmunology lab, to study how the immune system and the central nervous system communicate, both under healthy conditions and during disease !

👉 For more details : www.bordeaux-neurocampus.fr/en/team/neur...
Neuroimmunology lab - Bordeaux Neurocampus
Our team studies how the immune system and the central nervous system communicate, both under healthy conditions and during disease. We are particularly interested in how this two-way “neuroimmune” di...
www.bordeaux-neurocampus.fr
September 8, 2025 at 1:29 PM
Reposted by Institute of Neurodegenerative Diseases
📰 L’atrophie multi-systématisée est une pathologie neurodégénérative rare, proche de la maladie de Parkinson. Quels sont les signes cliniques ? Comment la diagnostiquer, la prendre en charge ? Le point dans Femme Actuelle avec Wassilios Meissner @imn-bordeaux.bsky.social : www.femmeactuelle.fr...
Atrophie multi-systématisée : diagnostic, prise en charge et pronostic de cette maladie proche de Parkinson
L’atrophie multi-systématisée est une pathologie neurodégénérative rare, proche de la maladie de Parkinson. Quels sont les signes cliniques ? Comment la diagnostiquer et la prendre en charge ? Le point avec le Pr Wassilios Meissner, chef du service de neurologie des maladies neurodégénératives au CHU de Bordeaux, et coordinateur national du centre de référence de l’AMS.
www.femmeactuelle.fr
July 23, 2025 at 7:01 AM
Reposted by Institute of Neurodegenerative Diseases
August #ImageOfTheMonth is from L.Congiu from
@imn-bordeaux.bsky.social. This is a 3D reconstruction of a CD68-positive particles (white) within the cell body of microglia cells (Red) in the mouse cortex. The confocal Z-stack was processed with Imaris software.
August 7, 2025 at 6:56 PM
Reposted by Institute of Neurodegenerative Diseases
September #ImageOfTheMonth is from @rkinet.bsky.social from @imn-bordeaux.bsky.social
This is a maximum projection of a confocal image of a microglia cell (blue) and its nucleus (red), internalising multiple nanoparticles (yellow), one day after supranigral injection in C57B6-J mouse
September 8, 2025 at 9:09 AM
Multiple System Atrophy is a rare neurodegenerative disorder closely related to Parkinson's disease.
🔎 But what are its clinical signs? How is it diagnosed and managed?
🕵 Here's an update from Pr. Wassilios Meissner
🗞️ Article : www.femmeactuelle.fr/sante/sante-...
Atrophie multi-systématisée : diagnostic, prise en charge et pronostic de cette maladie proche de Parkinson
L’atrophie multi-systématisée est une pathologie neurodégénérative rare, proche de la maladie de Parkinson. Quels sont les signes cliniques ? Comment la diagnostiquer et la prendre en charge ? Le point avec le Pr Wassilios Meissner, chef du service de neurologie des maladies neurodégénératives au CHU de Bordeaux, et coordinateur national du centre de référence de l’AMS.
www.femmeactuelle.fr
July 16, 2025 at 1:14 PM
OHBM is coming to Bordeaux in 2026 🥳
📍 Advance the understanding of the anatomical and functional organization of the human brain, and promote its medical and societal applications 🧠
📅 June 14-18th, 2026
👥 Co-organised by @micheltds.bsky.social and C. Foulon
🎥 produced by Koffi Productions 🥖 🇫🇷 🍷
OHBM 2026 Bordeaux
YouTube video by Clinical Neuroanatomy Seminars
www.youtube.com
July 2, 2025 at 9:26 AM