Lightnews — Scholar-powered news

Institut Necker Enfants Malades @inem-necker.bsky.social · Jul 17

[PUBLICATION] The @membramics-lab.bsky.social shows how Influenza A virus rewires ER lipid metabolism to promote vRNP egress.

👏🏼 Co-1st authors: Carla Alemany & @julianedagraca.bsky.social

journals.plos.org/plosbiology/...

w/ @institutpasteur.bsky.social & IPNP
@plosbiology.org

2 5

Institut Necker Enfants Malades @inem-necker.bsky.social · Jul 16

[PUBLICATION] NEW in @cp-cellreports.bsky.social
@julianedagraca.bsky.social et al. show that ER-endosome contacts act as hubs for phagophore formation during starvation.

📖 www.cell.com/cell-reports...
@membramics-lab.bsky.social

6

Institut Necker Enfants Malades @inem-necker.bsky.social · Jul 11

👏🏼 Proud to see @julianedagraca.bsky.social, former PhD student at INEM, honored with the 2025 Beth Levine Thesis Prize for her outstanding work on autophagy, supervised by Etienne Morel @membramics-lab.bsky.social.

CFATG (French Autophagy Network) @cfatg.bsky.social · Jul 11

🎉 Congratulations to @julianedagraca.bsky.social, recipient of the 2025 Beth Levine #ThesisPrize! Her outstanding research @membramics-lab.bsky.social on the role of ER/Endosome contact sites in the regulation of #autophagy captures the award's spirit of excellence and innovation. 👏

1 6

Institut Necker Enfants Malades @inem-necker.bsky.social · Jul 10

[CAREER] A 3-year PhD position is open in Paris to explore how air pollution contributes to CKD. The project combines experimental and environmental science and is hosted by INEM & LISA.

📨 Apply by Sept 1.
🟢 Start Nov–Dec 2025.

www.institut-necker-enfants-malades.fr/offre-demplo...

Institut Necker Enfants Malades @inem-necker.bsky.social · Jul 8

🚨 We're hiring! INEM is recruiting a Group Leader in #Immunology. Join a vibrant biomedical research institute with strong clinical & academic links.

🗓 Apply by Sept 20, 2025

🔗 More info: institut-necker-enfants-malades.fr/careers

Institut Necker Enfants Malades @inem-necker.bsky.social · Jul 2

[PUBLICATION] New study with the Bharat lab @cellbiol-mrclmb.bsky.social reveals the structure of the Neisseria meningitidis filamentous phage MDAΦ. 🦠
Cryo-EM/ET show how phage bundling supports biofilm formation & pathogenesis.
@mathieucoureuil.bsky.social @pnas.org

www.pnas.org/doi/10.1073/...

1

Institut Necker Enfants Malades @inem-necker.bsky.social · Jun 30

[PUBLICATION] PIK3CA mutations in Schwann cells trigger neuropathy by disrupting nearby healthy tissues. This non-cell autonomous effect shifts local metabolism toward aerobic glycolysis. Early alpelisib treatment is key. | Canaud Lab @pnas.org
🔗https://www.pnas.org/doi/10.1073/pnas.2424867122

Institut Necker Enfants Malades @inem-necker.bsky.social · Jun 27

[PUBLICATION] Podocyte-specific YAP activation drives crescentic glomerulonephritis via cross-talk with parietal epithelial cells. 🌙
A study from @fabiolaterzi.bsky.social & @marco-pontoglio.bsky.social labs now out in Science Translational Medicine @science.org
👉 www.science.org/doi/10.1126/...

Institut Necker Enfants Malades @inem-necker.bsky.social · Jun 27

🗓️ Join us on July 4, for a #seminar with David Sabatini, group leader at @iocbprague.bsky.social.
Dr. Sabatini will explore nutrient sensing by the mTOR pathway. Don’t miss it! @mario-pende.bsky.social

2 3

Institut Necker Enfants Malades @inem-necker.bsky.social · Jun 26

[PUBLICATION] mTORC1 coordinates ependymal cell differentiation by regulating an alternative cell cycle and centrosomal proteins.
A new collaboration between the Pende and Spassky labs!

🔗 www.embopress.org/doi/full/10....
@mario-pende.bsky.social @ibensens.bsky.social ‪@emboreports.org

Institut Necker Enfants Malades @inem-necker.bsky.social · Jun 19

[PUBLICATION] First report of successful pregnancies after treatment with alpelisib for PIK3CA-related overgrowth spectrum.

➡️Fertility preserved
➡️No embryotoxicity
➡️Disease remained responsive after treatment pause

📖 Read more: www.nature.com/articles/s41...
@ejhg-journal.bsky.social‬

1 1

Institut Necker Enfants Malades @inem-necker.bsky.social · Jun 13

🗓️ Join us on June 20, for a #seminar with Jean-Emmanuel Sarry, team leader at CRCT Oncopole. Dr. Sarry will explore Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia. Don’t miss it!

Institut Necker Enfants Malades @inem-necker.bsky.social · Jun 6

🗓️ Join us on June 13, for a #seminar with Han Li, Principal Investigator and leader of the cellular plasticity in age-related pathologies group at @pasteur.fr. Prof. Li will explore senescence induced-cellular plasticity in health & disease. Don’t miss it! @mario-pende.bsky.social

2

Institut Necker Enfants Malades @inem-necker.bsky.social · Jun 5

✨ Calling all postdocs! The 2025-2026 #ParisPostdocs Seminars are now accepting applications.
Present your work, connect across 13 top Paris institutes — including INEM — and boost your visibility 🚀.

Paris Postdocs Seminars @parispostdocs.bsky.social · Jun 3

Big news! Applications for the 2025/2026 Paris Postdocs Seminars series are now open ⭐

Don’t miss the chance to present your scientific work in one of our 13 participating institutes and increase your network!

📆 Register by June 15th, 2025 here: docs.google.com/forms/d/e/1F...

#ParisPostdocs

Paris Postdocs Seminars - 2025/2026 series

Application form for the 2025/2026 Paris Postdocs Seminar series

docs.google.com

1 1

Institut Necker Enfants Malades @inem-necker.bsky.social · Jun 3

🗓️ Join us on Friday, June 6, for a #seminar with Elvira Mass, Head of the Department of Developmental Biology of the Immune System at LIMES Institute @unibonn.bsky.social. ‬
Prof. Mass will explore the developmental programming of tissue-resident macrophages. Don’t miss it!
@venteclefn.bsky.social

1

Institut Necker Enfants Malades @inem-necker.bsky.social · May 20

Join #ParisPostdocsSeminar this month to hear from our very own Laura Salavessa (@laurasalavessa.bsky.social) as she shares new insights on melanin transfer and uptake in keratinocytes.

📅 Tuesday, 27 May
🕚 11:00–12:00 CET
📍 Institut Pasteur – Amphitheatre Agnès Ullmann

Paris Postdocs Seminars @parispostdocs.bsky.social · May 19

This month’s #ParisPostdocsSeminar features @laurasalavessa.bsky.social from @inem-necker.bsky.social, presenting her latest results on the transfer and uptake of melanin in keratinocytes for skin homeostasis!

📅 Tuesday, 27 May 2025
🕚 11:00–12:00 CET
📍 Amphitheatre Agnès Ullmann, @pasteur.fr

1 2

Institut Necker Enfants Malades @inem-necker.bsky.social · May 20

🚨 We're hiring! The IMMEDIAB team is looking for:
🧪 1 Postdoc
🧬 1 Research Assistant / Bioinfo/ Tech
📍 Paris | Start Sept 2025
📄 Full details + apply: www.institut-necker-enfants-malades.fr/careers
@drfalzaid.bsky.social

Institut Necker Enfants Malades @inem-necker.bsky.social · May 20

[PUBLICATION] Treating patients with somatic PIK3R1 mutations using alpelisib leads to clinical and radiological improvement.
A promising step toward targeted therapy in PIK3R1-related disorders.
📄Read more: www.embopress.org/doi/full/10....
Canaud Lab @emboreports.org

Institut Necker Enfants Malades @inem-necker.bsky.social · May 9

🗓️ Join us on Friday, May 16, for a #seminar with Chantal Desdouets, Head of the "Genomic Instability, Metabolism, Immunity and Liver Tumorigenesis" team at @crcordeliers.bsky.social.
Dr. Desdouets will explore Polyploidy in chronic liver diseases. Don’t miss it! @goffinlab.bsky.social

1

Institut Necker Enfants Malades @inem-necker.bsky.social · Apr 29

🗓️ Join us for a special #seminar with Bing Su, Director of the Shanghai Institute of Immunology & Chair at Shanghai JiaoTong Univ. School of Medicine.
Prof. Su will explore Sin1-mTOR signaling in immune cell metabolism, growth & survival. Don't miss it! @venteclefn.bsky.social @upcite.bsky.social

2

Institut Necker Enfants Malades @inem-necker.bsky.social · Apr 25

🗓️ Join us on Monday, Apr 28, for a #seminar with Christopher Goodnow, Head of the Immunogenomics Lab at @garvaninstitute.bsky.social.
Prof. Goodnow will explore how B cell tolerance breaks and resists rituximab treatment. Don’t miss it! @matthieumahevas.bsky.social

1 3

Institut Necker Enfants Malades @inem-necker.bsky.social · Apr 18

🎉 Congrats to Khaled Tighanimine, former PhD student at INEM (supervised by @mario-pende.bsky.social & Stefano Fumagalli), awarded a @fondationarc.bsky.social Oberling-Haguenau Thesis Prize!
Proud to see his work recognised among this year’s #ARCTrophies winners 👏

Fondation ARC pour la recherche sur le cancer @fondationarc.bsky.social · Apr 16

Six lauréats, quatre Français, un Algérien et un Américain ont été récompensés pour leurs travaux. Un grand bravo au Pr Eric Vivier, au Pr Yang Shi, au Dr Giacomo Cavalli, au Pr Hervé Avet-Loiseau, à Khaled Tighanimine et à Léa Montégut.

1 3

Institut Necker Enfants Malades @inem-necker.bsky.social · Apr 18

🗓️ Join us Friday, Apr 25 for a #seminar with Brendan Manning — Professor and Chair of Molecular Metabolism at Harvard T.H. Chan School of Public Health.
He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social

1 2 4

Institut Necker Enfants Malades @inem-necker.bsky.social · Apr 15

🚨 Postdoc Opportunity

Join the "Host-Pathogen Integrative Biology" team at INEM to study endothelial microparticles in cardiovascular dysfunctions during bacterial sepsis.

🌐More info & application: institut-necker-enfants-malades.fr/offre-demplo...

@mathieucoureuil.bsky.social

1

Institut Necker Enfants Malades @inem-necker.bsky.social · Apr 4

🗓️ Join us on Friday, April 11, for a #seminar with Prof. Philippe Sansonetti @pasteur.fr on Gut dysbiosis and colorectal cancer.
Don’t miss this talk diving into how microbial imbalances shape cancer development — and how we move from observation to mechanistic insight.

1 3 6