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Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Jul 14

NCCN released updated Genetic/Familial High-Risk Assessment: #Colorectal, #Endometrial, #Gastric #Cancer guidelines on June 13th, including updates to clinical diagnostic criteria for #PeutzJeghersSyndrome among many other important updates. Read more at www.nccn.org/professional...

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Jul 11

Watch an excerpt from yesterday's #ICARE #Genetics Case Conference during which Elizabeth Swisher, MD from the University of Washington discusses Myelodysplastic Syndrome (#MDS) and Acute Myeloid #Leukemia (#AML) following #PARPinhibitor therapy ⤸
youtu.be/t4PthACSQ00

Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) Following PARP Inhibitor Therapy.

YouTube video by Inherited Cancer Registry (ICARE)

youtu.be

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Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Jul 10

NCCN just released updated Genetic/Familial High-Risk Assessment: #Breast, #Ovarian, #Pancreatic, & #Prostate #Cancer guidelines today! These new guidelines include updates to #CHEK2, #PALB2, #TP53, & #PTEN content and much more! Check them out at: www.nccn.org/professional...

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Jul 9

Watch an exciting presentation from the @NCCN 2025 Annual Conference to learn about genes related to #prostate, #endometrial, & #gastric #cancers as well as the expanded recommendations in the #NCCN Guidelines for Genetic/Familial High-Risk Assessment ⤵
education.nccn.org/node/97031

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Jul 8

A trial among #BRCA carriers comparing neoadjuvant #chemo with #olaparib vs. chemo alone found no improvement in pathologic response (64.1% vs. 69.8%) yet significant improvement in overall survival at 3 yrs (100% vs. 88.2%). Read the full article at: www.nature.com/articles/s41...

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Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Jul 1

July is #Sarcoma and #BoneCancer #Awareness Month! Inherited #genes that lead to higher risks of these tumors include: #TP53, #RB1, #NF1, #APC, #KIT & #PDGFR. To learn more, read the following article 👇
www.ncbi.nlm.nih.gov/pmc/articles...

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Jun 24

A new study found that compared to those with #BRCA2 variants outside exon 11, those with exon 11 mutations had lower #breastcancer risk, higher risk for ER-negative disease, and later age at diagnosis.

Learn more at: pubmed.ncbi.nlm.nih.gov/40288678/
@myesmo.bsky.social

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Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Jun 17

A new study showed that among men at highest risk of #prostatecancer based on #PRS, more were found to have clinically significant disease (i.e., Gleason 7 or higher) than would have been found with PSA or MRI.
🔗 Learn more at:
www.nejm.org/doi/full/10....

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Jun 13

Watch yesterday's #ICARE #Genetics Case Conference during which Joanne Kotsopoulos, PhD from the Women's College Hospital Research Institute discusses hormonal risks in women with hereditary #breast and #ovarian #cancer syndrome (HBOC) ⤸
youtu.be/NhEbQhmu79E

Hormonal Risks in Women with Hereditary Breast and Ovarian Cancer Syndrome

YouTube video by Inherited Cancer Registry (ICARE)

youtu.be

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Jun 10

A microsimulation model showed that #cascadetesting lowered #colorectalcancer cases by 61% and deaths from colorectal #cancer by 78.5%, showing how much testing can help family members of those with #Lynchsyndrome newly diagnosed with colorectal cancer ⤵
pubmed.ncbi.nlm.nih.gov/40010417/

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Jun 6

A study showed that compared to non-carriers, #ATM, #CHEK2, & #PALB2 carriers showed similar mortality from breast cancer, pancreatic cancer, & colorectal cancer. These results may be reassuring for these carriers. Learn more at: pubmed.ncbi.nlm.nih.gov/40020204/

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Jun 3

A study comparing #PREMM5 & #PREMMplus found that PREMMplus was just as good as PREMM5 in identifying patients with #LynchSyndrome. PREMMplus also identifies individuals at risk for other inherited #cancer risk #genes. Learn more at: pubmed.ncbi.nlm.nih.gov/39772830/

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · May 30

May is #SkinCancerAwarenessMonth! Pathogenic variants in #CDKN2A #BAP1 #POT1 & #CDK4 are associated with increased #melanoma risk. #GorlinSyndrome, caused by pathogenic variants in #PTCH1, is associated with increased #basalcellcarcinoma risk. Learn more👇
www.cancer.gov/types/skin/h...

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · May 27

A study among #FAP patients, most of whom had a colectomy to prevent #cancer, found that although risk-reducing #colectomy is now standard practice in FAP patients, colorectal cancer remains the most common cancer and cause of death. Learn more at: pubmed.ncbi.nlm.nih.gov/39932215/

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · May 23

A study suggests that #BRIP1 might be the 3rd most common gene for inherited #ovariancancer. #BRCA mutations were found in almost 15%, while the frequency of mutations in other HRR genes were:
• #BRIP1 1.1%
• #PALB2 0.8%
• #RAD51C 0.4%
• #RAD51D 0.4%
pubmed.ncbi.nlm.nih.gov/39096152/

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · May 21

A meta-analysis study looking at prior studies of #PARPinhibitors in those with metastatic castration-resistant #prostatecancer showed the greatest benefit in #BRCA carriers and no benefit in #ATM or #CHEK2 carriers. Learn more at ⤸
pubmed.ncbi.nlm.nih.gov/39848867/
@euplatinum.bsky.social

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Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · May 5

A new study based on work in mice showed that an EZH2 inhibitor (called GSK503) given over 9 weeks in mice lowered the number of #adenomas that formed. Thus, EZH2 might be able to modulate immune-related #genes. Learn more at: pubmed.ncbi.nlm.nih.gov/39946195/

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · May 2

In recognition of #NationalCancerResearchMonth, we would like to raise #awareness about the incredible impact inherited #cancer #research has on the treatment & management of those at risk for #inheritedcancer. To learn more about #ICARE or enroll online, visit inheritedcancer.net

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · May 2

Watch yesterday's #ICARE #Genetics Case Conference during which Dr. Antonis Antoniou from the University of Cambridge discusses updates to #CanRisk, including adaptations for ethnically diverse populations and extensions to predict #prostatecancer #risk ⤸
youtu.be/bnhtdoXEjiU

CanRisk:Adaptations to Ethnically Diverse Populations and Extensions to Predict Prostate Cancer Risk

YouTube video by Inherited Cancer Registry (ICARE)

youtu.be

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · May 1

May is #SkinCancerAwarenessMonth! Pathogenic variants in #CDKN2A #BAP1 #POT1 & #CDK4 are associated with increased #melanoma risk. #GorlinSyndrome, caused by pathogenic variants in #PTCH1, is associated with increased #basalcellcarcinoma risk. Learn more👇
www.cancer.gov/types/skin/h...

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Apr 30

It is #NationalMinorityCancerAwarenessMonth! This month we would like to highlight the importance of #diversity in #cancerresearch. Not including minority populations in cancer research can further widen disparities! Spread awareness by sharing this post with friends and family.

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Apr 28

A new case series of 47 children with #LiFraumeniSyndrome diagnosed with a solid #cancer at or below age 16 found that the time to developing a new cancer and survival were MUCH shorter in those who received radiation. Learn more at: pubmed.ncbi.nlm.nih.gov/40059635/

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Apr 28

In recognition of #NationalCancerControlMonth, we encourage you to speak with your healthcare provider to make sure you are up-to-date on your #cancer #screenings to #preventcancer or find it early.

Help spread awareness by sharing this post with friends and family!

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Apr 24

A study found that cancer was commonly found in #MSH6 & #PMS2 carriers even under age 30. Recommendations suggest delaying colonoscopy until age 30 in these carriers, thus study authors suggest this may lead to missed opportunities for preventing cancer. Learn more: pubmed.ncbi.nlm.nih.gov/40013688/

Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · Apr 23

Through #ICARE, we are conducting free #genomic testing on #breast #tumor samples to better understand inherited #breastcancers. Enroll in ICARE using the link below and we will assess your eligibility for this and other focused research efforts
redcap.link/ICAREconsent