Lightnews — Scholar-powered news

InterPro

@interprodb.bsky.social

400 followers 380 following 35 posts

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. ebi.ac.uk/interpro/

Posts Media Videos Starter Packs

Pinned

InterPro @interprodb.bsky.social · Jun 20

🚀 InterPro 106.0 is now live!
✨ Updated to Pfam 37.4
✨ 683 new entries added
✨ Enhanced protein classification coverage
Explore the latest annotations and discover new protein insights.
Explore it now: interpro.ebi.ac.uk 💻🧪🧬
#Bioinformatics #ProteinScience #Pfam #EMBLEBI

InterPro 106.0
19th June 2025

Databases updates:
Pfam 37.4

New entries:
683 new entries with:
613 Pfam
78 NCBIfam
30 CDD
4 PANTHER
...

InterPro @interprodb.bsky.social · 6d

Quinoa thrives at 4,000m altitude where many crops struggle. Heat Shock Proteins helps protect plant cells from environmental stress. These molecular mechanisms in traditional crops may inform climate-resilient agriculture strategies. 💻🧪
More info: proteinswebteam.github.io/interpro-blo...

InterPro page with a list of the quinoa sequences in UniProtKB that belong to the HSP70 family.

InterPro @interprodb.bsky.social · 21d

Interested in studying Parkinson's disease? Have a look at our blog post below

InterPro @interprodb.bsky.social · Jan 31

🧬🧪💻 New blog post: Diving deep into the key proteins behind Parkinson's disease. From α-synuclein to LRRK2, we're unravelling the molecular mysteries that could hold the key to treatment breakthroughs. Read more: proteinswebteam.github.io/interpro-blo... #Parkinsons #Neuroscience

Parkinson's disease molecular mechanisms.
Source: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61393-3/fulltext#fig3

Reposted by InterPro

Ensembl @ensembl.org · Sep 2

📢 Happy to announce that Ensembl 115 and Ensembl Genomes 62 are out! This release features ~120000 new protein coding transcripts in human GRCh38, 2 new cattle, 7 new plants and 20 new metazoa! 🧬🐮 🫛🪲
Read more here ➡️ zurl.co/poyXM

Ensembl 115 has been released! – Ensembl Blog

InterPro @interprodb.bsky.social · Aug 27

Try it now on your favorite InterPro entry! www.ebi.ac.uk/interpro/ent...

InterPro @interprodb.bsky.social · Aug 27

Click any segment to:
✨List matching proteins
✨Download FASTA files
✨Jump to the taxonomy entry for deeper insights

InterPro @interprodb.bsky.social · Aug 27

Control the depth and display mode—view by number of sequences or number of species.

InterPro @interprodb.bsky.social · Aug 27

It maps protein occurrences from broad kingdoms down to specific species. See how widely a domain or site appears across life.

InterPro @interprodb.bsky.social · Aug 27

Feature Spotlight: Taxonomy Sunburst
Discover the taxonomic breadth of your InterPro entry at a glance with our dynamic sunburst chart! 🕸️ 💻🧪🧬

InterPro @interprodb.bsky.social · Aug 8

InterProScan 6 (beta) is here 🎉
A Nextflow-powered, containerised overhaul for scalable, reproducible protein annotation—decoupled software/data, automated data handling, and smoother runs across HPC and cloud.
Feedback welcome!
github.com/ebi-pf-team/...
💻🧪🧬

InterProScan 6 (beta)
Nextflow - Containerised - Reproducible outputs
Start with FASTA file
InterProScan workflow:
Annotate proteins (and nucleotides) with families, domains & sites
Select analyses (e.g. Pfam, PANTHER, CDD, NCBIFAM...)
Optional: GO and pathway annotations
Output formats: JSON, TSV, XML, GFF3

InterPro @interprodb.bsky.social · Jul 18

🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool!
🎤 Multiple talks & 📊 posters on protein analysis & classification
💻🧪

Poster A-098: Pfam database in 2025 – towards expanding protein families coverage
Nicole Morveli Flores
Session A: 21/07/2025
10:00 – 11:20 and
16:00 – 16:40 BST
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI

InterProScan 6: a modern large-scale protein function annotation pipeline
Matthias Blum
21/07/2025 14:20
Room 03A
Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

Poster A-205: Carbohydrate active enzymes in Pectobacteriaceae: coevolving enzyme sets and host adaptation
Emma Hobbs
Session A: 21/07/2025
10:00 – 11:20 and
16:00 – 16:40 BST
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI

Accelerating protein family classification in InterPro with AI innovations
Matthias Blum
22/07/2025 16:40
Room 12
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI

InterPro @interprodb.bsky.social · Jul 18

🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool!
Join us July 20-24 at the world's largest #bioinformatics conference!
#ISMBECCB2025 #ProteinAnalysis #ComputationalBiology
💻🧪

The InterPro/Pfam team members attending ISMB/ECCB 2025: Alex Bateman, Emma Hobbs, Matthias Blum, Nicole Morvelli, Antonina Andreeva
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI

InterPro @interprodb.bsky.social · Jul 7

🧬✨ Excited to present at @jobim2025.bsky.social this week in Bordeaux!
🎤 Talk 08/07 16:50, amphi E: Pfam: embracing AI/ML by @typhainepl.bsky.social
📊 Poster #97: InterPro: Accelerating Protein Annotation with AI by @matthiasblum.bsky.social
💻🧪

Reposted by InterPro

EMBL-EBI Training @training.ebi.embl.org · Jun 26

Level up your protein prediction skills with the updated EMBL-EBI Training AlphaFold practical course.

Now featuring #AlphaFold Server and AlphaFold 3. Start your training today: www.ebi.ac.uk/training/onl...

AlphaFold, developed by @ebi.embl.org‬ and Google DeepMind.

InterPro @interprodb.bsky.social · Jun 26

Does taste depend on our genes? Discover how variations in taste receptors—from TAS2Rs that gate bitterness to olfactory genes that make cilantro taste soapy—and even pain receptors for spice shape what we love (and hate) on our plates. Read more: proteinswebteam.github.io/interpro-blo... 💻🧪👅🧬

Schematic diagram showing taste signal transmission between the tongue (with taste buds that contain taste cells harbouring GPCRs) and brain. Taste GPCRs are activated by specific food compounds, recruit specific G proteins that further induce intracellular calcium release. Adapted from [https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28:_Biosignaling_-_Capstone_Volume_I/28.18:_Signal_Transduction_-_Taste_(Gustation)].

InterPro @interprodb.bsky.social · Jun 20

🚀 InterPro 106.0 is now live!
✨ Updated to Pfam 37.4
✨ 683 new entries added
✨ Enhanced protein classification coverage
Explore the latest annotations and discover new protein insights.
Explore it now: interpro.ebi.ac.uk 💻🧪🧬
#Bioinformatics #ProteinScience #Pfam #EMBLEBI

InterPro 106.0
19th June 2025

Databases updates:
Pfam 37.4

New entries:
683 new entries with:
613 Pfam
78 NCBIfam
30 CDD
4 PANTHER
...

Reposted by InterPro

Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · Jun 16

What’s new in the redesigned PDBe entry pages?

🧪 Cleaner layout
🧪 Interactive 3D viewers
🧪 Contextual annotations
🧪 Easier navigation

See for yourself:
wwwdev.ebi.ac.uk/pdbe/entry/p...

#PDBeBeta #Bioinformatics #Biochemistry #Science

Reposted by InterPro

EMBL-EBI @ebi.embl.org · Jun 12

InterPro just got one of its biggest updates ever.

Now with 1.8 billion AI-driven protein annotations, AlphaFold-based TED domains, and viral proteins from the Big Fantastic Virus Database (BFVD).

See it all at www.ebi.ac.uk/interpro

🖥️🧬

@interprodb.bsky.social

InterPro @interprodb.bsky.social · Jun 3

@martinsteinegger.bsky.social

InterPro @interprodb.bsky.social · Jun 3

🦠🧬Exciting news! BFVD predicted viral protein structures are now available in @InterProDB!
For the first time, explore InterPro functional annotations directly on 3D structures of viral proteins not covered by AlphaFold DB. This bridges a critical gap in structural virology research.

CATH-Gene3D annotation visualised on BFVD structure prediction of UniProt A0A075FDU7

InterPro @interprodb.bsky.social · May 20

We are saddened to hear of the passing of Daniel Kahn, the creator of the ProDom database. His pioneering work in protein domain classification laid important groundwork for InterPro and the wider bioinformatics community. We honour his lasting contributions. 🧬🕊️

InterPro @interprodb.bsky.social · May 15

🧬 MAJOR UPDATE: InterPro-N matches now available in InterPro!
1.8 billion AI-driven protein annotations developed with Google DeepMind are now live.
✨ Look for the sparkles icon to identify them
📊 Options menu lets you view: InterPro only | InterPro-N-only | Stacked
💻🧪

InterPro @interprodb.bsky.social · May 8

🔍 NEW: TED domains in InterPro 105.0!

For the first time, see AlphaFold-derived structural domains directly alongside InterPro annotations in one powerful visualisation. Bridging the sequence-structure divide in protein analysis. 💻🧪

Explore now: www.ebi.ac.uk/interpro/pro...

TED domains alongside InterPro annotations for UniProt P05067

InterPro @interprodb.bsky.social · May 1

📝 Check out our new blog post highlighting the groundbreaking features in InterPro 105.0!
Learn how InterPro-N, TED domains and viral protein structures are transforming protein classification: ebi.ac.uk/about/news/u...

InterPro 105.0: AI for protein classification
InterPro 105.0 is now live. This AI-driven update makes it easier than ever to explore the protein universe

InterPro @interprodb.bsky.social · Apr 24

📢InterPro release 105.0 is live!
✨Update to Pfam 37.3, PROSITE patterns 2025_01
PROSITE profiles 2025_01 and HAMAP 2025_01
✨342 new entries
✨Addition of InterPro-N annotations
✨Addition of BFVD structure predictions from @martinsteinegger.bsky.social's lab
Have a look: ebi.ac.uk/interpro/htt...
💻🧪🆕

InterPro 105.0
24th April 2025

Databases updates
Pfam 37.3
PROSITE patterns 2025_01
PROSITE profiles 2025_01
HAMAP 2025_01

New entries
342 new entries with:
318 Pfam
40 NCBIfam
12 Prosite profiles
6 PANTHER
5 CDD

New features
InterPro-N annotations
BFVD structure predictions
Simplified structure pages

InterPro @interprodb.bsky.social · Apr 11

Missed our latest webinar about LLM generated summaries for protein classification at InterPro delivered by
@matthiasblum.bsky.social?
The recording is now available: lnkd.in/ei4fKGXd

LLM generated summaries for protein classification at InterPro