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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · 8d

🎉 Big congratulations to @karkam.bsky.social who has just been awarded the PRO RETINA Research Award 2025 for her latest paper in American Journal of Human Genetics!

#ResearchAward #AcademicBlueSky #Ophthalmology #MacularDystrophy #Lysosomes #RetinalDisease #VisionResearch #RareDiseases

IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · Mar 12

New hope for inherited vision loss
IOB researchers (@karkam.bsky.social, @carlorivolta.bsky.social, @mquinodoz.bsky.social, @abimoye.bsky.social) identify AP5Z1, AP5M1, AP5B1 mutations, revealing new causes of macular dystrophy.
🔗 www.cell.com/ajhg/fulltex...
#AcademicBlueSky #Ophthalmology

Bi-allelic variants in three genes encoding distinct subunits of the vesicular AP-5 complex cause hereditary macular dystrophy

We discovered genetic changes in three genes (AP5Z1, AP5M1, and AP5B1) that cause macular degeneration, affecting sharp central vision. The proteins encoded by these genes form a complex that helps th...

www.cell.com

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · 8d

🚨 CALL FOR APPLICATIONS 🚨

Looking for your next academic step?
Join our interdisciplinary IOB MD-PhD / PhD Program to explore the visual system and pioneer therapies for eye diseases.

⏰ Deadline: November 16, 2025 (midnight CET)

🔗 iob.ch/phd-md-phd-program

#IOB #Basel #PhDProgram #VisionScience

iob.ch

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · 20d

Can a blind retina be made sensitive to infrared light? Our team shows that an engineered human TRPV1 channel, delivered by AAV, elicits robust responses without foreign proteins or nanoparticles.
🔗 bit.ly/4gt0LO5
#AcademicBlueSky #ProteinEngineering #TRPChannels #SyntheticBiology #Vision #Retina

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Reposted by IOB - Institute of Molecular and Clinical Ophthalmology Basel

IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · 22d

🧬 How can we navigate the genetic complexity of inherited retinal diseases?
Our new paper in @ajhgnews.bsky.social presents RetiGene, a curated atlas of IRD genes, built with @erdc-team.bsky.social, to support diagnosis, research and therapy.
👉 bit.ly/467U1S9
#AcademicBlueSky #IRDs #VisionResearch

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · 22d

🧬 How can we navigate the genetic complexity of inherited retinal diseases?
Our new paper in @ajhgnews.bsky.social presents RetiGene, a curated atlas of IRD genes, built with @erdc-team.bsky.social, to support diagnosis, research and therapy.
👉 bit.ly/467U1S9
#AcademicBlueSky #IRDs #VisionResearch

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · 22d

🔬👁️ Organoids in the spotlight!
Magdalena Renner, leading IOB’s organoid platform, shares how high-throughput organoid systems are transforming research and speeding up the path to therapies for eye diseases. Read more: bit.ly/4mquwjP
#VisionResearch #HistoBrick #Blindness #Retina #AcademicBlueSky

Reposted by IOB - Institute of Molecular and Clinical Ophthalmology Basel

Georg Kosche @gek0s.bsky.social · 23d

Single-cell electroporation is performed via patch pipette and under 2-photon visual guidance in vivo. A short voltage pulse train is applied through the pipette to deliver RNA molecules into a targeted cell. The video below shows this process in cortical neurons expressing GCaMP6s.

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Reposted by IOB - Institute of Molecular and Clinical Ophthalmology Basel

Georg Kosche @gek0s.bsky.social · 23d

Gene editing of single, targeted neurons in vivo is now feasible. We are proud to present our preprint for highly efficient single-cell electroporation using RNA. With @alex-fratzl.bsky.social, @munzlab.bsky.social, Botond Roska @iobswiss.bsky.social
#neuroskyence
www.biorxiv.org/content/10.1...

In vivo single-cell gene editing using RNA electroporation reveals sequential adaptation of cortical neurons to excitatory-inhibitory imbalance

The balance between excitatory and inhibitory neurotransmission is fundamental for normal brain function, yet the adaptation of individual neurons to disrupted excitatory-inhibitory balance is not wel...

www.biorxiv.org

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · 29d

👏Warm congratulations to our former IOB postdoctoral fellow @fionamuellner.bsky.social on her new role as Group Leader at @dandrite.bsky.social & Associate Professor at Aarhus University — and on receiving a prestigious ERC Starting Grant!
@erc.europa.eu

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · Aug 14

This changes how we think about vision: timing coordination starts in the eye - not the brain! Check out @anbucci.bsky.social & @ffranke.bsky.social's discovery: nature.com/articles/s41...
#Neuroscience #Vision #RGCs #RetinalResearch #AcademicBlueSky #EyeResearch #ScientificDiscovery

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Reposted by IOB - Institute of Molecular and Clinical Ophthalmology Basel

IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · Aug 13

🧠👁️ How does your eye prevent seeing a scrambled world? @anbucci.bsky.social and @ffranke.bsky.social reveal the eye's secret "clockwork": bigger axons = faster signals = perfect visual timing!
📖 Full paper nature.com/articles/s41593-025-02011-3
#Vision #AcademicSky #Neuroscience #Retina
Image ©IOB

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · Aug 13

🧠👁️ How does your eye prevent seeing a scrambled world? @anbucci.bsky.social and @ffranke.bsky.social reveal the eye's secret "clockwork": bigger axons = faster signals = perfect visual timing!
📖 Full paper nature.com/articles/s41593-025-02011-3
#Vision #AcademicSky #Neuroscience #Retina
Image ©IOB

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · Jun 4

🚨 We are hiring!
IOB is looking for an enthusiastic IT career starter (Level 1 Helpdesk) to join our support team. Whether you are a student, graduate, or making a career change, this entry-level role is a great opportunity to launch your path in IT.
Interested? 👉 iob.ch/join-iob/ope...
#AcademicSky

Open Positions: IOB

iob.ch

IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · May 13

🧬👁️Discover how research and patient care come together in the latest Novartis Live magazine — with stories from the labs and clinics shaping the future of vision.

🔗 bit.ly/4km6XZ0

#IOB #VisionScience #TranslationalResearch #Basel #Ophthalmology #AcademicSky #Novartis

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · May 8

🔬 We are hiring!

Research Assistant/Associate (100%) – Molecular Mechanisms of Myopia

📍 Location: Basel
🧪 Background in molecular biology, genomics, neuroscience or related field
💼 Full-time position

Apply now or share!
iob.ch/join-iob/ope...

Open Positions: IOB

iob.ch

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · Apr 16

What controls eye growth?
10 key insights from decades of myopia research - from retinal feedback to red light therapy, here is what we know:
🔗 onlinelibrary.wiley.com/doi/10.1111/...

#Myopia #VisionResearch #Ophthalmology #GlobalHealth #AcademicBlueSky

Image © IOB, generated with Google AI, 2025

IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · Apr 15

🧬IOB researchers (@Mukhtarullah.bsky.social
@karkam.bsky.social @carlorivolta.bsky.social
@mquinodoz.bsky.social) and international team uncover genetic signatures of eye diseases in Pakistan
📖 doi.org/10.1038/s415...
#Genetics #Vision #AcademicSky

Image © IOB, generated with Google AI, Gemini

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · Mar 21

🧠 Brain efficiency doesn't need perfect organization

Random neural responses can lead to better information processing than precisely tuned ones.

www.sciencedirect.com/science/arti...

@ravadasilveira.bsky.social | image © IOB, 2025
#AcademicSky #Neuroscience #ScienceNews

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · Mar 12

New hope for inherited vision loss
IOB researchers (@karkam.bsky.social, @carlorivolta.bsky.social, @mquinodoz.bsky.social, @abimoye.bsky.social) identify AP5Z1, AP5M1, AP5B1 mutations, revealing new causes of macular dystrophy.
🔗 www.cell.com/ajhg/fulltex...
#AcademicBlueSky #Ophthalmology

Bi-allelic variants in three genes encoding distinct subunits of the vesicular AP-5 complex cause hereditary macular dystrophy

We discovered genetic changes in three genes (AP5Z1, AP5M1, and AP5B1) that cause macular degeneration, affecting sharp central vision. The proteins encoded by these genes form a complex that helps th...

www.cell.com

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · Feb 24

🧠 How does your brain create mental maps?

New research reveals a surprisingly simple mathematical principle behind complex spatial representations! From rodents to bats, same rules apply 🐁🦇

#Neuroscience #BrainScience #ScienceNews #AcademicBluesky

Read more here: www.cell.com/neuron/fullt...

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · Feb 20

We are thrilled to have contributed to this innovative research published in Advanced Functional Materials, together with the team of @tobiasruff.bsky.social‬ at ETH!

Check out the full paper: advanced.onlinelibrary.wiley.com/doi/10.1002/...
🧠 #neuroscience #brainresearch #academicsky

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Reposted by IOB - Institute of Molecular and Clinical Ophthalmology Basel

Tamas Dalmay @tdalmay.bsky.social · Feb 12

How do different sensory signals combine in the computation of cognitive maps? I’m thrilled to share our new preprint, in which we investigate this question in the context of the head-direction system:
www.biorxiv.org/content/10.1...

Joint visual-vestibular computation of head direction and reflexive eye movement

Several cognitive maps have been identified, but what sensory signals drive them and how these are combined are not well understood. One such map, the head-direction representation, is believed to be ...

www.biorxiv.org

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · Feb 11

🔍 Did you ever wonder why your eyes make tiny movements even when trying to hold still?

Those movements are not a bug, they are an essential feature for sharp vision!

Here is why: www.pnas.org/doi/epub/10....

#AcademicSky #Neuroscience #Ophthalmology

Illustration ©IOB, 2025

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Reposted by IOB - Institute of Molecular and Clinical Ophthalmology Basel

IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · Jan 21

👁️ Advancing Vision Research 👁️
Our latest study with collaborators from CSEM introduces a HistoBrick array made from a novel material mix, optimizing cryosectioning and immunohistochemistry for retinal organoids and small tissues.

📖 Learn more: rdcu.be/d5o8Z
#Organoids #AcademicSky
Picture © IOB

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Reposted by IOB - Institute of Molecular and Clinical Ophthalmology Basel

University of Basel @unibas.ch · Jan 9

A research team from @iobswiss.bsky.social and the University of Basel has developed a therapy to treat Stargardt disease, which often leads to vision loss. Its study shows promising results using a precise technique for gene correction.

Precision gene editing could prevent vision loss from Stargardt disease

Researchers have developed a therapy to treat Stargardt disease, the most common form of inherited macular degeneration, which often leads to vision loss. Their study shows promising results using a p...

www.unibas.ch

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