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Reposted by Ionel Sandovici

Cahir O'Kane @cahirokane.bsky.social · 4d

Sad to hear of the death of John Gurdon this morning, aged 92.

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Reposted by Ionel Sandovici

Gurdon Institute, University of Cambridge @gurdoninstitute.bsky.social · 23d

Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.

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dfachinetti.bsky.social @dfachinetti.bsky.social · Sep 4

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

DNA methylation influences human centromere positioning and function - Nature Genetics

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

www.nature.com

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Dr. Jeffrey Millman @jeffreymillman.bsky.social · Aug 28

[please retweet] I’m #hiring! The Millman Lab is looking for a postdoctoral researcher to lead an exciting new project focused on vascularized #stemcell-derived islets for #diabetes disease modeling and cell replacement therapy. Email me your CV and cover letter.

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Ionel Sandovici @isandovici.bsky.social · Aug 27

A very nice paper in the developmental programming field, linking childhood eczema to maternal stress during pregnancy. rdcu.be/eCKOI

Maternal stress triggers early-life eczema through fetal mast cell programming

Nature - Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in...

rdcu.be

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Ionel Sandovici @isandovici.bsky.social · Aug 25

Glad to see this review out. Epigenetic Changes Associated With Obesity-related Metabolic Comorbidities url: academic.oup.com/jes/article/...

Epigenetic Changes Associated With Obesity-related Metabolic Comorbidities

Abstract. Obesity arises from a complex interaction of genetic, hormonal, dietary, and behavioral factors that drive chronic energy imbalance, excessive fa

academic.oup.com

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Stefan Schoenfelder @stefanschoenfelder.bsky.social · Jul 22

🚨 New paper alert 🚨
I am excited to share our new work on epigenetic enhancer priming in early mammalian development
genomebiology.biomedcentral.com/articles/10....
Fantastic collaboration with Wolf Reik’s team, with key contributions from many others, led by the excellent Chris Todd.
Short 🧵

Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks - Genome Biology

Background Embryonic development requires the accurate spatiotemporal execution of cell lineage-specific gene expression programs, which are controlled by transcriptional enhancers. Developmental enha...

genomebiology.biomedcentral.com

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Lennart Hilbert @lennarthilbert.bsky.social · Jul 26

How do enhancer-gene contacts relate to transcription activation? In mouse embryonic stem cells, a combo of STED, oligoFISH & RNA FISH shows that 3% of Dppa3 alleles transcribe. For these, enhancers and promoters come closer (panel E). Stumberger ... Leonhardt & Harz www.biorxiv.org/content/10.1...

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Nitzan Gonen @nitzan-gonen.bsky.social · Jul 27

1/n Very excited to share our recent paper published on
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!

The gene regulatory landscape driving mouse gonadal supporting cell differentiation

Multiomics analysis revealed the regulatory elements and transcription factors responsible for gonadal sex determination.

science.org

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Juliane Glaser @julianeg.bsky.social · Jul 9

Also, check out the News & Views summarizing our findings, written by Youjia Guo & @themodzlab.bsky.social 🤩🤩
www.nature.com/articles/s41...

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Ulla Sovio @ullasovio.bsky.social · Jun 19

Are you passionate about data and do you enjoy coding in Stata? Come and work with me at the Department of Obstetrics & Gynaecology in Cambridge! Please share with anyone who might be interested, and feel free to reach out if you have any questions. www.jobs.cam.ac.uk/job/51739/

Research Associate (Data Science) (Fixed Term) - Job Opportunities - University of Cambridge

Research Associate (Data Science) (Fixed Term) in the Department of Obstetrics and Gynaecology at the University of Cambridge.

www.jobs.cam.ac.uk

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Ionel Sandovici @isandovici.bsky.social · Jun 4

Very cool paper connecting nutrition, epigenetics and developmental biology. rdcu.be/eptl7

Maternal iron deficiency causes male-to-female sex reversal in mouse embryos

Nature - Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.

rdcu.be

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Ionel Sandovici @isandovici.bsky.social · Jun 4

Happy to see this paper from David Grattan’s lab (@prolactinguy.bsky.social). And glad to have made a small contribution. Loss of choroid plexus‐derived insulin‐like growth factor 2 (IGF2) leads to hyposmia, while retaining post‐partum mood resilience in mice. onlinelibrary.wiley.com/doi/10.1111/...

<em>Journal of Neuroendocrinology</em> | BSN Journal | Wiley Online Library

During the post-partum period, new mothers are vulnerable to mood disorders. In adults, impairments in neurogenesis commonly associate with anxiety and depressive behaviors. Insulin-like growth facto....

onlinelibrary.wiley.com

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Turner Lab @lab-turner.bsky.social · May 14

We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵

Divergent DNA methylation dynamics in marsupial and eutherian embryos - Nature

A study reports on the DNA methylation dynamics during embryogenesis in marsupials, showing that these differ from those occurring during embryogenesis in eutherian mammals.

www.nature.com

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Ionel Sandovici @isandovici.bsky.social · Apr 25

Had an amazing day at the Epigenetics meeting organised by the Genetics Society UK and was very happy to present our work on a search for new regulators of adipogenesis. Learning a lot from all the talks and posters presented.

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Genetics Society UK @gensocuk.bsky.social · Apr 23

🎉 Huge congratulations to Prof. Kathy Niakan on receiving the 2025 Mary Lyon Medal! @niakanlab.bsky.social's Mary Lyon Medal lecture is on the genetic approaches to study early lineage specification in human embryos.
#Epigenetics2025

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Roychoudhuri Lab @roychoudhurilab.bsky.social · Mar 5

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

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andrewpospisilik.bsky.social @andrewpospisilik.bsky.social · Jan 27

Wondering whether your cancer risk might start before you are born? Our latest work published in #Nature Cancer suggests it does, through regulation by Trim28 and #epigenetic silencing. Congratulations to @ilariapanzeri.bsky.social for spearheading! Read it here: www.nature.com/articles/s43...

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states - Nature Cancer

Panzeri et al. use a Trim28+/D9 mouse model with intrinsic developmental heterogeneity to show that ‘heavy’ and ‘light’ developmental morphs exhibit different timing, type and severity of cancer, link...

www.nature.com

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Turner Lab @lab-turner.bsky.social · Jan 24

We thrilled to see our latest study led by @jeremie-subrini.bsky.social now out in @science.org 🔬

What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬

www.science.org/doi/full/10....

www.science.org

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Irene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · Jan 24

Small but mighty: multiple Y chromosome contributions to mouse spermatogenesis @lab-turner.bsky.social
www.science.org/doi/10.1126/...

Systematic identification of Y-chromosome gene functions in mouse spermatogenesis

The mammalian Y chromosome is essential for male fertility, but which Y genes regulate spermatogenesis is unresolved. We addressed this by generating 13 Y-deletant mouse models. In Eif2s3y, Uty, and Z...

www.science.org

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Miguel Branco @brancolab.bsky.social · Jan 21

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below.
Please spread the word.

Postdoctoral Research Associate - QMUL Jobs

ID: 4897. Title: Postdoctoral Research Associate . Application Deadline:

qmul-jobs.tal.net

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Wellcome Connecting Science Learning and Training @eventswcs.bsky.social · Jan 6

Meet our excellent speakers joining us for #GenomicImprinting25:

@arburga.bsky.social
@cwhanna.bsky.social
@daannoordermeerlab.bsky.social
@eddaschulz.bsky.social

Join us for an exploration into how the latest #ImprintingResearch is advancing the clinical treatment of imprinting disorders 🔽

Wellcome Connecting Science Learning and Training @eventswcs.bsky.social · Jan 6

Present your genomic imprinting insights at our 2025 conference! #GenomicImprinting25

Demonstrate how breakthroughs in the field are paving the way for improved clinical care of #ImprintingDisorders

⏰Submit your abstract by 15 January!
📎 Find out more: bit.ly/4gefA61

#VariantInterpretation

Wellcome Connecting Science
Genomic Imprinting: From Biology to Disease hybrid conference
10-12 March 2025
Location: Hinxton Hall Conference Centre, Wellcome Genome Campus, UK and online
Bursary deadline: 10 December 2024
Abstract deadline: 15 January 2025
In-person registration deadline: 11 February 2025
Virtual registration deadline: 4 March 2025

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brumbaugh-lab.bsky.social @brumbaugh-lab.bsky.social · Jan 10

Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!

H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium

Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...

rdcu.be

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Ionel Sandovici @isandovici.bsky.social · Jan 9

Congratulations, Courtney and colleagues!

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Courtney Hanna @cwhanna.bsky.social · Jan 8

Excited to share our most recent work in Cell Stem Cell, led by @georgiaplea.bsky.social, characterising determinants of DNA methylation patterning in human trophoblast stem cells! A great collaboration with @vpglab.bsky.social.
tinyurl.com/93mchcd2

@loke-ctr.bsky.social @cam-repro.bsky.social

Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome

The placental DNA methylation landscape is unique, with widespread partially methylated domains (PMDs). The placental “methylome” is conserved across …

tinyurl.com

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