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Juliane Glaser

@julianeg.bsky.social

930 followers 400 following 130 posts

Independent Group Leader at the MPI-IE passionate about mechanisms governing embryonic development with a focus on transposable elements🧬 Postdoc @MundlosLab 🇩🇪| PhD from @Bourchis lab 🇫🇷| She/her https://www.julianeglaserlab.com/

www.julianeglaserlab.com

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Juliane Glaser @julianeg.bsky.social · Jul 9

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics

Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

www.nature.com

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Reposted by Juliane Glaser

Alex de Mendoza @alexdemendoza.bsky.social · 1d

Thrilled to share that the lab has been awarded a @wellcometrust.bsky.social Discovery Award to keep exploring the evolution of 6-methyladenine #6mA in Eukaryotes. We'll open postdoc (3️⃣) and tech (1️⃣) positions to start in 2026, please share with candidates or reach out if you’d like to join us.

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Reposted by Juliane Glaser

Edda Schulz @eddaschulz.bsky.social · 3d

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

www.nature.com

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Reposted by Juliane Glaser

Raquel Fueyo @fueyoraquel.bsky.social · 3d

⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab

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Reposted by Juliane Glaser

Adriano Bolondi @adrianobolondi.bsky.social · 7d

🚨JOB ALERT🚨

FRIENDS PLEASE SPREAD and RT

We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.

See below 2 calls👇

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Juliane Glaser @julianeg.bsky.social · 7d

I hope so too! Would be really great to catch up :) I am not sure yet but I will let you know!

Reposted by Juliane Glaser

Raquel Fueyo @fueyoraquel.bsky.social · 7d

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

A human-specific regulatory mechanism revealed in a pre-implantation model

Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

rdcu.be

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Juliane Glaser @julianeg.bsky.social · 7d

Beautiful work!!! Congratulations Raquel 🥂

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Reposted by Juliane Glaser

Bas van Steensel lab (NKI) @basvansteensellab.bsky.social · 15d

Our reporter hopping scaled up to thousands of integrations in a single locus, to produce high-resolution functional maps, with plenty of interesting insights: www.science.org/doi/10.1126/...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

www.science.org

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Reposted by Juliane Glaser

Jamie Hackett @jamiehackett.bsky.social · 12d

❓Can a father’s environmental exposures before conception influence their offspring?

We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences

www.embopress.org/doi/full/10....

Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal

imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

www.embopress.org

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Reposted by Juliane Glaser

Manuel Irimia @mirimiam.bsky.social · 17d

Last days to apply! Cool project, cool cities! :-)

(Please repost! 🙏)

Manuel Irimia @mirimiam.bsky.social · Jul 23

🚨🚨🚨

Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇

www.upf.edu

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Reposted by Juliane Glaser

Max-Planck-Gesellschaft @maxplanck.de · 24d

Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...

Graphic with a blue background and light green dots. The text 'call for applications' appears in green, and 'Ausschreibung' in white. A white arrow on the right points diagonally upward.

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Reposted by Juliane Glaser

Jan Żylicz @jzylicz.bsky.social · 21d

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

HDAC3 prevents enhancer hyperactivation to enable developmental transitions

Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

www.biorxiv.org

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Reposted by Juliane Glaser

Maxim Greenberg @maxvcg.bsky.social · 23d

Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...

Epigenetic relay: Polycomb-directed DNA methylation in mammalian development

In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...

journals.plos.org

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Reposted by Juliane Glaser

canaztekin.bsky.social @canaztekin.bsky.social · 24d

🚀 Looking for a Bioinformatician / Data Scientist to join our crew and explore regeneration through single-cell genomics & evolutionary biology! @mpi-bio-fml.bsky.social
📩 Questions? Contact us ✉️
🔗 Apply here: www.mpg.de/25243280/bio...

Bioinformatician / Data Scientist (m/f/d)

Bioinformatician / Data scientist position in the Aztekin Lab focusing on Structural Regeneration and support the working group together with the other members

www.mpg.de

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Juliane Glaser @julianeg.bsky.social · 29d

Thank you Fany! 😊

Juliane Glaser @julianeg.bsky.social · Sep 8

Thank you Danny!!!!

Juliane Glaser @julianeg.bsky.social · Sep 7

Check out @annaamonaco.bsky.social piece on our recent story 🧬🦠 ✋🏻
& have a look at her website, Anna is an amazing science communicator and writes about discoveries on the non-coding “dark” genome! Thank you for highlighting our work 🤩

Anna A Monaco @annaamonaco.bsky.social · Sep 7

A bit late, but I finally got around to writing an accessible piece about @julianeg.bsky.social 's cover article from July. In case you needed something else to worry about in this day and age! 🦠

tinyurl.com/mrx5tfre
#scicomm #devbio #transposons