Daniel Ibrahim
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danielibrahim.bsky.social
Daniel Ibrahim
@danielibrahim.bsky.social
Group Leader @ BIH Berlin and MPI Molecular Genetics. I play around with DNA because I‘d like to know how the genome functions.
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What is a promoter? And how does it work?

We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters

www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
Reposted by Daniel Ibrahim
🔬 Hot #PhD topic: Single-molecule fluorescence and super-resolution microscopy! Use quantitative nanoscale imaging to map nuclear organization. Apply by Jan 7 to join Johannes Stein’s Lab @jmstein.bsky.social & #IMPRS-BAC #gradschool!

👉 www.molgen.mpg.de/5098010/stei...
November 25, 2025 at 2:18 PM
I 100% subscribe to this post!
I really do not want to read a paraphrased version of whatever is written on my website. Just write me a nice email if you're interested.
Students applying for grad school, or reaching out to professors. I have an important piece of advice for you: STOP DOING THIS 👇 (a thread) #STEM #PhD #gradschool #academictips
November 24, 2025 at 10:23 AM
Reposted by Daniel Ibrahim
Very proud of our new paper! Great job @mweilert.bsky.social, our experimentalists and modeling collaborator Rosa Martinez-Corral. It was fun to see the story grow and get feedback from various experts. Thank you all!
November 19, 2025 at 11:38 PM
Reposted by Daniel Ibrahim
IMPRS-BAC #gradschool: Our new groupleader @sedonamurphy.bsky.social has an open PhD project in her lab. Topic: Spatial feedback between epigenetic regulation and chromatin regulation. Apply by Jan 7, 2026!
👉 www.molgen.mpg.de/5091778/Murp...
November 18, 2025 at 4:05 PM
Reposted by Daniel Ibrahim
1. We start a major consortium programme funded by the sLoLa of BBSRC (shorturl.at/aUbnt) to decipher the semantic rules of enhancer arrangements driving regulator genes of development (shorturl.at/6qcjW).
shorturl.at
November 18, 2025 at 12:48 PM
Reposted by Daniel Ibrahim
This mural has gone up in Kingston, ostensibly for Christmas but AI has ensured it's actually to celebrate the return of our dark lord Cthulhu
November 18, 2025 at 9:44 AM
Reposted by Daniel Ibrahim
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨

#PhD #3DGenome
November 15, 2025 at 9:53 AM
Reposted by Daniel Ibrahim
We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
November 6, 2025 at 6:37 PM
Reposted by Daniel Ibrahim
🚀 WE ARE HIRING 3️⃣ Independent Group Leaders for #mdcBerlin's new cutting-edge Bioengineering Cluster within our Biomedical Engineering Program.

Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin.

👉 Apply now: www.mdc-berlin.de/career/jobs/...
October 9, 2025 at 11:00 AM
Reposted by Daniel Ibrahim
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
October 27, 2025 at 11:49 AM
Reposted by Daniel Ibrahim
What happens when you change the promoter of my favorite gene? Sox9?
October 25, 2025 at 8:04 AM
Reposted by Daniel Ibrahim
My new lab at the @molgen.mpg.de will be following up on some of the nuclear organization aspects of ecDNA so please do reach out if this is of interest :)
October 21, 2025 at 9:43 AM
Reposted by Daniel Ibrahim
Our publication is out today!Big Thanks go to my amazing collaborators: @sedonamurphy.bsky.social for her imaging brilliance and @mattjones.bsky.social for his computational support.They both saw the potential in this project and helped me to explore what turned out to be an exciting discovery.
October 21, 2025 at 1:34 PM
Reposted by Daniel Ibrahim
📢 We are hiring!
👩🏾‍⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution

Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...

#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
October 15, 2025 at 3:00 PM
Reposted by Daniel Ibrahim
Out now! 🎉 Check the thread & preprint to see why we think E–P specificity is real in mammals — and, well, a few other interesting things popped up too 👀
Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬
October 17, 2025 at 5:50 AM
Reposted by Daniel Ibrahim
super cool to see this out! looking forward to now read the details! Congratulations, Yad and @mmasoura.bsky.social
October 16, 2025 at 6:31 PM
Reposted by Daniel Ibrahim
What mediates enhancer-promoter compatibility? Get some answers & learn about the important of the promoter-proximal
region here 👇
Congratulations @blanka-majchrzycka.bsky.social @danielibrahim.bsky.social on this beautiful work!!!!🥂🥂
October 16, 2025 at 3:23 PM
Reposted by Daniel Ibrahim
Yay! Congratulations @blanka-majchrzycka.bsky.social and @danielibrahim.bsky.social ! Good to see this beautiful dissection out !
October 16, 2025 at 4:34 PM
Reposted by Daniel Ibrahim
A genetic engineering tour de force by @blanka-majchrzycka.bsky.social. Systematic dissection of promoter function in relevant genomic context! Spoiler, promoter matters! Happy we could help on this!
October 16, 2025 at 4:05 PM
What is a promoter? And how does it work?

We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters

www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 16, 2025 at 3:06 PM
a really cool work! everyone check it out! congratulations 🎉👏🏽
October 16, 2025 at 1:55 PM
If you’re interested in a PhD that explores the ins and outs of genomes and the nucleus - don’t look further but apply here!!!
It is excellent 👌
🚨 Please share! We are seeking motivated PhD students who wish to work at the intersection of molecular life sciences and computational sciences.
#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...
October 9, 2025 at 12:49 PM
Reposted by Daniel Ibrahim
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
October 6, 2025 at 1:02 PM
Reposted by Daniel Ibrahim
⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab
October 6, 2025 at 1:46 PM
Reposted by Daniel Ibrahim
🚨JOB ALERT🚨

FRIENDS PLEASE SPREAD and RT

We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.

See below 2 calls👇
October 2, 2025 at 11:00 AM