Vicki Metzis
@vmetzis.bsky.social
Developmental biologist. Interested in how cells make decisions, genetics, genomics, gene regulation and stem cells. Group leader
@mrc-lms.bsky.social @imperialmed.bsky.social
@mrc-lms.bsky.social @imperialmed.bsky.social
Pinned
Vicki Metzis
@vmetzis.bsky.social
· Jun 27
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting!
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
October 23, 2025 at 5:25 PM
I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting!
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Many thanks James - pleased to share this publication and to see it highlighted in the current issue @cp-devcell.bsky.social
Great to see this from @vmetzis.bsky.social & co published
Dissection of CDX2 regulatory elements identifies a repressive element that converts to an enhancer with a nuclear receptor motif switch
www.cell.com/developmenta...
Dissection of CDX2 regulatory elements identifies a repressive element that converts to an enhancer with a nuclear receptor motif switch
www.cell.com/developmenta...
A dual enhancer-attenuator element ensures transient Cdx2 expression during mouse posterior body formation
Amblard et al. dissect the function of cis-regulatory elements regulating transient
Cdx2 expression during mouse caudal body formation. They highlight the requirement
of an attenuator, a transiently r...
www.cell.com
September 23, 2025 at 12:54 PM
Many thanks James - pleased to share this publication and to see it highlighted in the current issue @cp-devcell.bsky.social
Application deadline for up to 5 @mrc-lms.bsky.social postdoc positions in developmental epigenetics closes soon - don’t miss out! Positions across both experimental and computational projects. Come and join our fantastic team science community!
Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc!
Multiple positions across multiple groups @mrc-lms.bsky.social
Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇
lms.mrc.ac.uk/work/vacanci...
Multiple positions across multiple groups @mrc-lms.bsky.social
Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇
lms.mrc.ac.uk/work/vacanci...
MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences
Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.
lms.mrc.ac.uk
August 1, 2025 at 9:47 AM
Application deadline for up to 5 @mrc-lms.bsky.social postdoc positions in developmental epigenetics closes soon - don’t miss out! Positions across both experimental and computational projects. Come and join our fantastic team science community!
Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc!
Multiple positions across multiple groups @mrc-lms.bsky.social
Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇
lms.mrc.ac.uk/work/vacanci...
Multiple positions across multiple groups @mrc-lms.bsky.social
Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇
lms.mrc.ac.uk/work/vacanci...
MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences
Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.
lms.mrc.ac.uk
July 14, 2025 at 5:15 PM
Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc!
Multiple positions across multiple groups @mrc-lms.bsky.social
Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇
lms.mrc.ac.uk/work/vacanci...
Multiple positions across multiple groups @mrc-lms.bsky.social
Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇
lms.mrc.ac.uk/work/vacanci...
Reposted by Vicki Metzis
My team @ebi.embl.org is open to hosting #ARISE2 fellows!
We‘re especially interested in projects that improve access to single-cell & spatial transcriptomics data (e.g. browsers, standards), or enhance AI-readiness.
Happy to chat if you are applying!
www.embl.org/training/ari...
We‘re especially interested in projects that improve access to single-cell & spatial transcriptomics data (e.g. browsers, standards), or enhance AI-readiness.
Happy to chat if you are applying!
www.embl.org/training/ari...
July 11, 2025 at 1:22 PM
My team @ebi.embl.org is open to hosting #ARISE2 fellows!
We‘re especially interested in projects that improve access to single-cell & spatial transcriptomics data (e.g. browsers, standards), or enhance AI-readiness.
Happy to chat if you are applying!
www.embl.org/training/ari...
We‘re especially interested in projects that improve access to single-cell & spatial transcriptomics data (e.g. browsers, standards), or enhance AI-readiness.
Happy to chat if you are applying!
www.embl.org/training/ari...
Congratulations to my colleague Will Scott @mrc-lms.bsky.social on his latest work resolving the molecular changes in fat tissue that emerge following weight loss www.nature.com/articles/s41...
July 12, 2025 at 12:52 PM
Congratulations to my colleague Will Scott @mrc-lms.bsky.social on his latest work resolving the molecular changes in fat tissue that emerge following weight loss www.nature.com/articles/s41...
Reposted by Vicki Metzis
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
July 9, 2025 at 10:05 AM
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Reposted by Vicki Metzis
Are you a recent UK graduate without an MSc, eager to launch your career in biomedical research?
Apply now for our two-year Science Technology Graduate Programme!
You'll gain hands-on experience in state-of-the-art research facilities, build technical expertise and earn a competitive salary.
Apply now for our two-year Science Technology Graduate Programme!
You'll gain hands-on experience in state-of-the-art research facilities, build technical expertise and earn a competitive salary.
Science Technology Graduate Programme - MRC Laboratory of Medical Sciences
Bioinformatics Facility - Dr George Young and Electron Microscopy Facility - Dr Ricardo Aramayo
lms.mrc.ac.uk
July 4, 2025 at 1:58 PM
Are you a recent UK graduate without an MSc, eager to launch your career in biomedical research?
Apply now for our two-year Science Technology Graduate Programme!
You'll gain hands-on experience in state-of-the-art research facilities, build technical expertise and earn a competitive salary.
Apply now for our two-year Science Technology Graduate Programme!
You'll gain hands-on experience in state-of-the-art research facilities, build technical expertise and earn a competitive salary.
Reposted by Vicki Metzis
🎉Excited to share our latest paper, published in Nature Communications!🎉
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications
Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...
doi.org
June 27, 2025 at 11:21 AM
🎉Excited to share our latest paper, published in Nature Communications!🎉
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
Reposted by Vicki Metzis
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 2, 2025 at 4:17 PM
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Many thanks to @drsingleman.bsky.social for interviewing us about our latest work @imperialmed.bsky.social @mrc-lms.bsky.social - here’s her news story in GEN
www.genengnews.com/topics/genom...
www.genengnews.com/topics/genom...
Genetic “Dimmer Switch” Offers Precise Gene Expression Control
The duration of expression of the gene Cdx2 is tightly regulated by a newly identified DNA sequence element called an “attenuator.”
www.genengnews.com
June 28, 2025 at 10:44 AM
Many thanks to @drsingleman.bsky.social for interviewing us about our latest work @imperialmed.bsky.social @mrc-lms.bsky.social - here’s her news story in GEN
www.genengnews.com/topics/genom...
www.genengnews.com/topics/genom...
Reposted by Vicki Metzis
I am happy and extremely proud to be able to contribute to this work with Irène Amblard and @vmetzis.bsky.social, where by changing one motif we completely rewired the function of a regulatory element!🔬🧬 Now out in Developmental Cell!
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
June 28, 2025 at 8:22 AM
I am happy and extremely proud to be able to contribute to this work with Irène Amblard and @vmetzis.bsky.social, where by changing one motif we completely rewired the function of a regulatory element!🔬🧬 Now out in Developmental Cell!
Reposted by Vicki Metzis
Research published today in Developmental Cell uncovers a new mechanism that controls how genes are switched ‘on’ and ‘off’ during embryonic development.
The work holds potential for a variety of biomedical applications by unlocking new ways to control gene expression where and when it’s needed.
The work holds potential for a variety of biomedical applications by unlocking new ways to control gene expression where and when it’s needed.
A new genetic tuner for embryo development
A team of scientists at the MRC Laboratory of Medical Sciences (LMS) has uncovered a previously unknown mechanism that controls how genes are switched ‘on’ and ‘off’ during embryonic development. Publ...
lms.mrc.ac.uk
June 27, 2025 at 3:32 PM
Research published today in Developmental Cell uncovers a new mechanism that controls how genes are switched ‘on’ and ‘off’ during embryonic development.
The work holds potential for a variety of biomedical applications by unlocking new ways to control gene expression where and when it’s needed.
The work holds potential for a variety of biomedical applications by unlocking new ways to control gene expression where and when it’s needed.
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
June 27, 2025 at 3:07 PM
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
Reposted by Vicki Metzis
#JobAlert! We have an opening for a postdoctoral scientist in #CancerMetabolism in my lab @mrc-lms.bsky.social. If you're interested in the role of metabolism in drug response and resistance in cancer, and would like to work in a fun and friendly team, check it out: lms.mrc.ac.uk/work/vacanci...
MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences
The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...
lms.mrc.ac.uk
June 25, 2025 at 8:57 AM
#JobAlert! We have an opening for a postdoctoral scientist in #CancerMetabolism in my lab @mrc-lms.bsky.social. If you're interested in the role of metabolism in drug response and resistance in cancer, and would like to work in a fun and friendly team, check it out: lms.mrc.ac.uk/work/vacanci...
Save the date! March 23-26 will be the dates for our 2026 @bsdb.bsky.social annual meeting: Molecules to Morphogenesis!
Excited to reveal more details soon!
Want to attend with a reduced rate, and have access to conference/travel grants for other meetings too? Don't forget to join the BSDB :)
Excited to reveal more details soon!
Want to attend with a reduced rate, and have access to conference/travel grants for other meetings too? Don't forget to join the BSDB :)
June 18, 2025 at 2:29 PM
Save the date! March 23-26 will be the dates for our 2026 @bsdb.bsky.social annual meeting: Molecules to Morphogenesis!
Excited to reveal more details soon!
Want to attend with a reduced rate, and have access to conference/travel grants for other meetings too? Don't forget to join the BSDB :)
Excited to reveal more details soon!
Want to attend with a reduced rate, and have access to conference/travel grants for other meetings too? Don't forget to join the BSDB :)
Reposted by Vicki Metzis
Used EMBL-EBI data resources to find, analyse, or archive your data? 🧬
Now’s your turn: tell us how you’ve used them + why they matter.
It takes 15 mins and helps keep these services open and free for all.
👉 tinyurl.com/bdf73zpp
Closes 16 July
#opendata #FAIRdata
Now’s your turn: tell us how you’ve used them + why they matter.
It takes 15 mins and helps keep these services open and free for all.
👉 tinyurl.com/bdf73zpp
Closes 16 July
#opendata #FAIRdata
June 17, 2025 at 8:00 PM
Used EMBL-EBI data resources to find, analyse, or archive your data? 🧬
Now’s your turn: tell us how you’ve used them + why they matter.
It takes 15 mins and helps keep these services open and free for all.
👉 tinyurl.com/bdf73zpp
Closes 16 July
#opendata #FAIRdata
Now’s your turn: tell us how you’ve used them + why they matter.
It takes 15 mins and helps keep these services open and free for all.
👉 tinyurl.com/bdf73zpp
Closes 16 July
#opendata #FAIRdata
How does intra-tumour heterogeneity affect drug uptake and efficacy? Checkout how @louisefets.bsky.social and co dissect this important question in their latest preprint using an array of approaches and patient samples 👇
We’re excited to share a new pre-print from the lab! Led by Carmen Ramirez Moncayo and a fantastic collaboration with several groups from across @mrc-lms.bsky.social & @imperialcollegeldn.bsky.social. Interested in #OvarianCancer, #PARPinhibitors or #DrugDistribution? please read on! bit.ly/45lpekS
June 12, 2025 at 7:36 AM
How does intra-tumour heterogeneity affect drug uptake and efficacy? Checkout how @louisefets.bsky.social and co dissect this important question in their latest preprint using an array of approaches and patient samples 👇
Job alert! An exciting opportunity for Black heritage PhD graduates looking to progress their academic career
@mrc-lms.bsky.social
Many exciting labs and opportunities - check it out 👇👇👇
@mrc-lms.bsky.social
Many exciting labs and opportunities - check it out 👇👇👇
There's still time to apply for an Emerging Innovators Fellowship for scientists of Black heritage!
If you’re ready to take the next step in your career and make an impact in the world of biomedical research, we encourage you to apply.
Applications close 11 May 2025.
Find out more 👇
If you’re ready to take the next step in your career and make an impact in the world of biomedical research, we encourage you to apply.
Applications close 11 May 2025.
Find out more 👇
Emerging Innovators Fellowship - MRC Laboratory of Medical Sciences
The Emerging Innovators Fellowship is a new 3-year fully-funded postdoctoral fellowship for scientists from Black Heritage Backgrounds.
lms.mrc.ac.uk
May 2, 2025 at 10:04 AM
Job alert! An exciting opportunity for Black heritage PhD graduates looking to progress their academic career
@mrc-lms.bsky.social
Many exciting labs and opportunities - check it out 👇👇👇
@mrc-lms.bsky.social
Many exciting labs and opportunities - check it out 👇👇👇
Great to meet new and familiar faces and share our latest thoughts on strategies to finely tune gene expression at #Epigenetics2025!
We continue the session with @vmetzis.bsky.social from @mrc-lms.bsky.social discussing how a dual enhancer-attenuator element ensures transient Cdx2 expression during development #Epigenetics2025
April 25, 2025 at 12:24 PM
Great to meet new and familiar faces and share our latest thoughts on strategies to finely tune gene expression at #Epigenetics2025!
En route to Belfast - looking forward to catching up with friends and meeting new colleagues at Epigenetics 2025
@gensocuk.bsky.social
#regulatorylogic
genetics.org.uk/events/epige...
@gensocuk.bsky.social
#regulatorylogic
genetics.org.uk/events/epige...
Epigenetics-2025, from mechanisms to disease | Genetics Society
Meeting background This international conference will bring together leading experts to foster dynamic discussions on the latest breakthroughs in epigenetics. It will cover mechanisms of epigenetic re...
genetics.org.uk
April 23, 2025 at 7:09 AM
En route to Belfast - looking forward to catching up with friends and meeting new colleagues at Epigenetics 2025
@gensocuk.bsky.social
#regulatorylogic
genetics.org.uk/events/epige...
@gensocuk.bsky.social
#regulatorylogic
genetics.org.uk/events/epige...
Reposted by Vicki Metzis
Thanks Vicki!! We had to take down this thread (something with Pacmanoid and copyright) but you can find the thread rework with animated Pacmanoid here: bsky.app/profile/jess...
😱 A very hungry #PacManoid ate the original post 🍬🍬🍬
Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again!
Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st...
Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again!
Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st...
Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
April 19, 2025 at 9:02 AM
Thanks Vicki!! We had to take down this thread (something with Pacmanoid and copyright) but you can find the thread rework with animated Pacmanoid here: bsky.app/profile/jess...
Nice work from Vanessa Ribes highlighting dual regulatory roles (and a silencer) mediated by Pax TFs in the dorsal neural tube #biologists100
Always a pleasure seeing previous lab members present their own lab's work
The wonderful Vanessa Ribes discussing recent work on txn regulation by Pax3/7 in neural progenitors #biologists100
www.biorxiv.org/content/10.1...
The wonderful Vanessa Ribes discussing recent work on txn regulation by Pax3/7 in neural progenitors #biologists100
www.biorxiv.org/content/10.1...
March 27, 2025 at 2:17 PM
Nice work from Vanessa Ribes highlighting dual regulatory roles (and a silencer) mediated by Pax TFs in the dorsal neural tube #biologists100
“Play and share” - inspiring and important words from Manu Prakash @prakashlab.bsky.social at this morning’s session #biologists100 @biologists.bsky.social
March 27, 2025 at 10:44 AM
“Play and share” - inspiring and important words from Manu Prakash @prakashlab.bsky.social at this morning’s session #biologists100 @biologists.bsky.social
Reposted by Vicki Metzis
The most deserving winner of the 2025 Tickle Medal is Muzlifah Haniffa!
bsdb.org/2025/03/24/2...
bsdb.org/2025/03/24/2...
March 24, 2025 at 9:13 AM
The most deserving winner of the 2025 Tickle Medal is Muzlifah Haniffa!
bsdb.org/2025/03/24/2...
bsdb.org/2025/03/24/2...