@canaztekin.bsky.social
Group Leader @mpi-bio-fml.bsky.social/Branco Weiss Fellow. Studying how to regrow limbs! Alum: @EPFL ELISIR / @Cambridge_Uni @GurdonInstitute
EN/TR
EN/TR
Pinned
🚨Why can’t mammals regenerate legs or arms like frog tadpoles or salamanders?
Our preprint tackles (part of) this BIG question with surprising findings about oxygen sensing
🔗 www.biorxiv.org/content/10.1...
Happy New Year, everyone! 🎉
🐭 vs 🐸 #evodevo #regenerative #cellbio 🧵👇
Our preprint tackles (part of) this BIG question with surprising findings about oxygen sensing
🔗 www.biorxiv.org/content/10.1...
Happy New Year, everyone! 🎉
🐭 vs 🐸 #evodevo #regenerative #cellbio 🧵👇
Reposted
Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
Cadherins modulate the self-organizing potential of pseudo-embryos
Gastruloids derived from ES cells mimic embryonic patterning through robust self-organization.
Mayran et al. uncover that this competence depends on a cadherin switch regulated
by Snai1-driven E-cadhe...
www.cell.com
November 17, 2025 at 10:37 AM
Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
Reposted
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
🔬 Limb regeneration depends on regenerative signaling center cells — but how do these cells influence others to proliferate, migrate, or differentiate?
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
October 21, 2025 at 6:56 AM
🔬 Limb regeneration depends on regenerative signaling center cells — but how do these cells influence others to proliferate, migrate, or differentiate?
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
Reposted
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
October 11, 2025 at 8:22 AM
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
Reposted
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Induction of menstruation in mice reveals the regulation of menstrual shedding
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
October 10, 2025 at 12:50 PM
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Reposted
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
October 2, 2025 at 11:00 AM
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
Reposted
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted
Are you interested on how regenerating tissues transit between stages? Am sharing here our work showing that during #Xenopus tail regeneration, tissue stiffening activates a Piezo1-Yap1 mechanosensitive cascade to allow wounded epithelia to transit into regenerative states!
September 23, 2025 at 7:39 PM
Are you interested on how regenerating tissues transit between stages? Am sharing here our work showing that during #Xenopus tail regeneration, tissue stiffening activates a Piezo1-Yap1 mechanosensitive cascade to allow wounded epithelia to transit into regenerative states!
Reposted
📢 Institut Jacques Monod Seminars
📅 Oct. 7th
📍 Institut Jacques Monod
Invited by the @stemdevevo.bsky.social Lab , @canaztekin.bsky.social will present an Institut Jacques Monod seminar on the theme « Signaling centers of appendage regeneration: from single cells to species »
➡️ buff.ly/Nvw4YZn
📅 Oct. 7th
📍 Institut Jacques Monod
Invited by the @stemdevevo.bsky.social Lab , @canaztekin.bsky.social will present an Institut Jacques Monod seminar on the theme « Signaling centers of appendage regeneration: from single cells to species »
➡️ buff.ly/Nvw4YZn
September 23, 2025 at 8:01 AM
📢 Institut Jacques Monod Seminars
📅 Oct. 7th
📍 Institut Jacques Monod
Invited by the @stemdevevo.bsky.social Lab , @canaztekin.bsky.social will present an Institut Jacques Monod seminar on the theme « Signaling centers of appendage regeneration: from single cells to species »
➡️ buff.ly/Nvw4YZn
📅 Oct. 7th
📍 Institut Jacques Monod
Invited by the @stemdevevo.bsky.social Lab , @canaztekin.bsky.social will present an Institut Jacques Monod seminar on the theme « Signaling centers of appendage regeneration: from single cells to species »
➡️ buff.ly/Nvw4YZn
Reposted
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
September 22, 2025 at 9:37 AM
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
George, our very first postdoc (super brave!), has been central to so many projects. Had a hugely risky project that paved the way for his regeneration work. Proud to share it here again
#PostdocAppreciationWeek 🐸 vs 🐭 👇
🔗 www.biorxiv.org/content/10.1...
#PostdocAppreciationWeek 🐸 vs 🐭 👇
🔗 www.biorxiv.org/content/10.1...
September 18, 2025 at 1:39 PM
George, our very first postdoc (super brave!), has been central to so many projects. Had a hugely risky project that paved the way for his regeneration work. Proud to share it here again
#PostdocAppreciationWeek 🐸 vs 🐭 👇
🔗 www.biorxiv.org/content/10.1...
#PostdocAppreciationWeek 🐸 vs 🐭 👇
🔗 www.biorxiv.org/content/10.1...
Reposted
Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.
September 18, 2025 at 1:20 PM
Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.
Reposted
Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr
September 17, 2025 at 5:30 PM
Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr
🚀 Looking for a Bioinformatician / Data Scientist to join our crew and explore regeneration through single-cell genomics & evolutionary biology! @mpi-bio-fml.bsky.social
📩 Questions? Contact us ✉️
🔗 Apply here: www.mpg.de/25243280/bio...
📩 Questions? Contact us ✉️
🔗 Apply here: www.mpg.de/25243280/bio...
Bioinformatician / Data Scientist (m/f/d)
Bioinformatician / Data scientist position in the Aztekin Lab focusing on Structural Regeneration and support the working group together with the other members
www.mpg.de
September 15, 2025 at 6:58 AM
🚀 Looking for a Bioinformatician / Data Scientist to join our crew and explore regeneration through single-cell genomics & evolutionary biology! @mpi-bio-fml.bsky.social
📩 Questions? Contact us ✉️
🔗 Apply here: www.mpg.de/25243280/bio...
📩 Questions? Contact us ✉️
🔗 Apply here: www.mpg.de/25243280/bio...
Reposted
Excited to share our Review on human PGC development covering the latest in vivo observations & in vitro developments, esp. in the last 5 years. Have a read! journals.biologists.com/dev/article/...
From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social
From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social
Emerging principles and models of human primordial germ cell development
Summary: This Review examines recent insights into early human germ cell development and how these regulatory principles guide stem cell-derived models aiming to reconstitute human gametogenesis in vi...
journals.biologists.com
September 12, 2025 at 4:21 PM
Excited to share our Review on human PGC development covering the latest in vivo observations & in vitro developments, esp. in the last 5 years. Have a read! journals.biologists.com/dev/article/...
From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social
From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social
Reposted
Excited and very grateful to announce that I have been awarded an ERC Starting Grant by @erc.europa.eu! 🎉 This is a fantastic opportunity to further build my team at the Max Planck Institute of Immunobiology and Epigenetics (@mpi-ie.bsky.social) exploring new grounds in fundamental research:
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 7:19 PM
Excited and very grateful to announce that I have been awarded an ERC Starting Grant by @erc.europa.eu! 🎉 This is a fantastic opportunity to further build my team at the Max Planck Institute of Immunobiology and Epigenetics (@mpi-ie.bsky.social) exploring new grounds in fundamental research:
Reposted
🥳 Very grateful for the support of the ERC Starting Grant for my newly established lab! We will study how transposable elements contribute to mammalian embryonic development.
We will have positions available next year. Stay tuned!
We will have positions available next year. Stay tuned!
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 1:27 PM
🥳 Very grateful for the support of the ERC Starting Grant for my newly established lab! We will study how transposable elements contribute to mammalian embryonic development.
We will have positions available next year. Stay tuned!
We will have positions available next year. Stay tuned!
🥳 Thrilled to share that our lab has been awarded an ERC StGrant for our project SigReg: Signal to Regeneration!
How can we unlock limb regeneration in adult mammals?
It’s time to apply what we learned from 🐸 ➡️ 🐭
Thank you @erc.europa.eu for supporting ambitious science!!!
How can we unlock limb regeneration in adult mammals?
It’s time to apply what we learned from 🐸 ➡️ 🐭
Thank you @erc.europa.eu for supporting ambitious science!!!
Massive congratulations to @canaztekin.bsky.social for being awarded an ERC Starting Grant @erc.europa.eu ! 🎉 His "Signal to Regeneration" (SigReg) project will explore the potential of limb regeneration in mammals.
Read more and watch Can introduce his project: s.gwdg.de/cLAmJE
Read more and watch Can introduce his project: s.gwdg.de/cLAmJE
September 4, 2025 at 1:27 PM
🥳 Thrilled to share that our lab has been awarded an ERC StGrant for our project SigReg: Signal to Regeneration!
How can we unlock limb regeneration in adult mammals?
It’s time to apply what we learned from 🐸 ➡️ 🐭
Thank you @erc.europa.eu for supporting ambitious science!!!
How can we unlock limb regeneration in adult mammals?
It’s time to apply what we learned from 🐸 ➡️ 🐭
Thank you @erc.europa.eu for supporting ambitious science!!!
Reposted
If you want to feel like you know nothing about biology, read this paper. 😭 I want to get it. But brain not cooperating.
Look at this crazy thing!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...
www.nature.com
September 4, 2025 at 1:59 AM
If you want to feel like you know nothing about biology, read this paper. 😭 I want to get it. But brain not cooperating.
Reposted
Thrilled to share 🎉 I’m starting my lab at University of Zurich,
DMLS as Assistant Professor (tenure track) from Jan 2026!
The Neural MorphoGenomics & Developmental Dynamics Lab will be exploring how genes + morphogenesis shape brain development with organoids, imaging & spatial genomics 🧠🔬🧬
DMLS as Assistant Professor (tenure track) from Jan 2026!
The Neural MorphoGenomics & Developmental Dynamics Lab will be exploring how genes + morphogenesis shape brain development with organoids, imaging & spatial genomics 🧠🔬🧬
September 3, 2025 at 10:43 PM
Thrilled to share 🎉 I’m starting my lab at University of Zurich,
DMLS as Assistant Professor (tenure track) from Jan 2026!
The Neural MorphoGenomics & Developmental Dynamics Lab will be exploring how genes + morphogenesis shape brain development with organoids, imaging & spatial genomics 🧠🔬🧬
DMLS as Assistant Professor (tenure track) from Jan 2026!
The Neural MorphoGenomics & Developmental Dynamics Lab will be exploring how genes + morphogenesis shape brain development with organoids, imaging & spatial genomics 🧠🔬🧬
Reposted
1) I am delighted to present this terrific tour de force research conducted by my post-doc Dr. Gayani Senevirathne @gayani.bsky.social and published today in Nature -
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The evolution of hominin bipedalism in two steps - Nature
The human pelvis exhibits distinct spatiotemporal ossification patterns and an ilium cartilage growth plate that is shifted perpendicularly compared with those of other mammals and non-human primates—...
www.nature.com
August 27, 2025 at 3:13 PM
1) I am delighted to present this terrific tour de force research conducted by my post-doc Dr. Gayani Senevirathne @gayani.bsky.social and published today in Nature -
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
Announcing this year's Life Time Achievement Award. The one and only amazing Professor Brigette Galliot. Our inspiration with both her research and her service.
August 18, 2025 at 3:46 PM
Announcing this year's Life Time Achievement Award. The one and only amazing Professor Brigette Galliot. Our inspiration with both her research and her service.
Reposted
We are excited to highlight our Rising Star Awardee, Dr. Can Aztekin @canaztekin.bsky.social whose work highlighting the importance of oxygen in regulating regeneration is inspiring. #Onetowatch
August 18, 2025 at 3:38 PM
We are excited to highlight our Rising Star Awardee, Dr. Can Aztekin @canaztekin.bsky.social whose work highlighting the importance of oxygen in regulating regeneration is inspiring. #Onetowatch
Reposted
Very proud of our @canaztekin.bsky.social on his Rising Star Award 2025 from @isrbio.bsky.social! Find out more about his work on the structural limb #regeneration, specifically in understanding the differences in regeneration abilities across various species: s.gwdg.de/QidoUL #biology #maxplanck
August 18, 2025 at 8:50 AM
Very proud of our @canaztekin.bsky.social on his Rising Star Award 2025 from @isrbio.bsky.social! Find out more about his work on the structural limb #regeneration, specifically in understanding the differences in regeneration abilities across various species: s.gwdg.de/QidoUL #biology #maxplanck