Ishfaq Ahamd Pandith
banner
ishfaqahamdpandith.bsky.social
Ishfaq Ahamd Pandith
@ishfaqahamdpandith.bsky.social
Pro Reason, Pro Logic and Pro Evidence ¦🧬🔬🔺🔺🔺🧫🦠☕¦ MAX PLANCK INSTITUTE ¦ NCBS-TIFR ¦
KU BIOTECH
Reposted by Ishfaq Ahamd Pandith
New paper out!

How can we force HIV genomes out of their capsid shells and what can we learn about HIV biology doing so?

Hint: capsid inhibitors actively re-route nuclear HIV complexes, and expose genomes via intriguing structural effects!
open access:
link.springer.com/article/10.1...
read below
Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles - The EMBO Journal
Following cell entry, HIV-1 capsids enter the nucleus by passage through nuclear pores and reach nuclear speckles with subsequent uncoating of the reverse-transcribed genome and its integration into s...
link.springer.com
December 4, 2025 at 1:58 PM
Reposted by Ishfaq Ahamd Pandith
What is LiTEC? A brand new method which targets arbitrary cargo or enzyme into condensates using blue light 🔵. LiTEC provides new insights into the composition and behavior of condensates without disturbing their natural state. Now in CELL. Congrats to @choongman.bsky.social & Cissé lab team
Bringing Cellular Condensates to Light
Researchers at the MPI of Immunobiology and Epigenetics have developed LiTEC, a method for studying biomolecular condensates—membraneless compartments in cells that regulate key processes such as gene...
www.ie-freiburg.mpg.de
December 12, 2024 at 9:22 PM