Angel Felix - Ⓐ🏴 ⚛︎
LightNews LightNews
banner
italoromeno.bsky.social
Angel Felix - Ⓐ🏴 ⚛︎
@italoromeno.bsky.social
190 followers 220 following 230 posts
Ⓐ☭⚛︎H

«Know yourselves: be infertile and let the earth be silent after ye» -- The Last Messiah, P. W. Zapffe
--------------------------------------------------
#RRMS: #Tysabri, then #Tyruko, now #Ocrevus
Posts Replies Media Videos
Pinned
italoromeno.bsky.social
Angel Felix - Ⓐ🏴 ⚛︎ @italoromeno.bsky.social · Jan 24
www.science.org/doi/10.1126/...
Human endogenous retroviral protein triggers deficit in glutamate synapse maturation and behaviors associated with psychosis
Retroviral protein, expressed in patients with psychotic disorders, corrupts the development of excitatory synapses and behavior.
www.science.org
italoromeno.bsky.social
Dr. Lawrence Afrin presents “Mast Cell Activation Syndrome”
YouTube video by EDS Awareness
www.youtube.com
November 2, 2025 at 1:01 PM
italoromeno.bsky.social
youtu.be/PQBAhfUw_kQ?...
7 POWERFUL Ways to Reduce Histamine Inflammation Naturally
YouTube video by Dr. Paul Anderson
youtu.be
October 27, 2025 at 7:38 PM
italoromeno.bsky.social
pubmed.ncbi.nlm.nih.gov/23253152
Anti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic models - PubMed
We report here for the first time that artesunate possesses anti-allergic activity by blocking IgE-induced mast cell degranulation, providing a foundation for developing artesunate for the treatment o...
pubmed.ncbi.nlm.nih.gov
October 17, 2025 at 9:04 PM
italoromeno.bsky.social
www.sciencedirect.com/science/arti...
Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats
The gut microbiota affects intestinal permeability and mucosal mast cells (MMCs) responses. Activation of MMCs has been associated with absorption of …
www.sciencedirect.com
October 15, 2025 at 6:41 AM
Reposted by Angel Felix - Ⓐ🏴 ⚛︎
brandon-beaber.bsky.social
The effect on brain atrophy of different MS disease modifying therapies based on a network meta-analysis (click the image) pubmed.ncbi.nlm.nih.gov/41080911/
October 14, 2025 at 4:38 AM
italoromeno.bsky.social
www.drugtargetreview.com/news/189185/...
Pemafibrate and telmisartan combo may reverse fatty liver
Explore the latest findings on fatty liver disease and how approved drugs may reduce liver fat accumulation and cardiovascular risks.
www.drugtargetreview.com
October 14, 2025 at 7:04 AM
italoromeno.bsky.social
pubmed.ncbi.nlm.nih.gov/28057587/
Dual role of histamine on microglia-induced neurodegeneration - PubMed
Several hypotheses have been raised about the dual role of histamine in neurological disorders, and evidences have shown its crucial involvement in the modulation of microglia-mediated neuroinflammati...
pubmed.ncbi.nlm.nih.gov
October 11, 2025 at 1:11 AM
italoromeno.bsky.social
Title says it all.
pubmed.ncbi.nlm.nih.gov/27260166/
Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation - PubMed
Overall, our results highlight the relevance of histamine in the modulation of microglial activity that ultimately may interfere with neuronal survival in the context of Parkinson's disease (PD) and, ...
pubmed.ncbi.nlm.nih.gov
October 11, 2025 at 12:39 AM
italoromeno.bsky.social
pubmed.ncbi.nlm.nih.gov/33443845/
Mast Cell Changes the Phenotype of Microglia via Histamine and ATP - PubMed
Our results highlight the relevance of MC-derived histamine and ATP in the modulation of secretory and phagocytic activities that would explain the heterogeneity of microglial responses in different p...
pubmed.ncbi.nlm.nih.gov
October 11, 2025 at 12:26 AM
italoromeno.bsky.social
youtu.be/8NMvXD3JPJA?...
The POTScast E178: Mast Cell Matters: Psychiatric Manifestations of MCAS with Dr Janet Settle
YouTube video by Standing Up to POTS, Inc.
youtu.be
October 3, 2025 at 9:15 AM
italoromeno.bsky.social
www.nature.com/articles/s41...
Clemastine and metformin extend the window of NMDA receptor surface expression in ageing oligodendrocyte precursor cells - Scientific Reports
Scientific Reports - Clemastine and metformin extend the window of NMDA receptor surface expression in ageing oligodendrocyte precursor cells
www.nature.com
September 29, 2025 at 7:31 PM
italoromeno.bsky.social
pubmed.ncbi.nlm.nih.gov/16505314/
Allergy, histamine 1 receptor blockers, and the risk of multiple sclerosis - PubMed
These results do not support a strong link between allergic conditions and multiple sclerosis (MS) risk but suggest a possible beneficial effect of antihistamines on the onset of MS.
pubmed.ncbi.nlm.nih.gov
September 18, 2025 at 9:49 AM
italoromeno.bsky.social
pubmed.ncbi.nlm.nih.gov/31463682/
Calming Down Mast Cells with Ketotifen: A Potential Strategy for Multiple Sclerosis Therapy? - PubMed
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by extensive inflammation, demyelination, axonal loss and gliosis. Evidence indicates that mas...
pubmed.ncbi.nlm.nih.gov
September 18, 2025 at 7:07 AM
italoromeno.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC...
Viewpoints Sigma-1 receptor agonist fluvoxamine for multiple sclerosis
Accumulating evidence suggests that the Epstein-Barr virus (EBV) plays a key role in the development of multiple sclerosis (MS). Additionally, depressive symptoms often precede the onset of MS. Given ...
pmc.ncbi.nlm.nih.gov
August 15, 2025 at 2:57 PM
italoromeno.bsky.social
A Disease That Makes You Allergic to Meat And Dairy Is Spreading Around The World
Hours after savoring that perfectly grilled steak on a beautiful summer evening, your body turns traitor, declaring war on the very meal you just enjoyed.
www.sciencealert.com
August 7, 2025 at 6:04 PM
italoromeno.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC...
Long-Term Administration of Valacyclovir Reduces the Number of Epstein-Barr Virus (EBV)-Infected B Cells but Not the Number of EBV DNA Copies per B Cell in Healthy Volunteers
Epstein-Barr virus (EBV) establishes a latent infection in B cells in the blood, and the latent EBV load in healthy individuals is generally stable over time, maintaining a “set point.” It is unknown ...
pmc.ncbi.nlm.nih.gov
July 26, 2025 at 4:18 PM
Reposted by Angel Felix - Ⓐ🏴 ⚛︎
4aamari.bsky.social
ways of heron silhouettes
grey summer sky and its water mirror part to reveal pale glow surrounding far silhouette horizon and heron for a moment standing in ripples beyond framing branch and leaf of always marsh’s water’s edge
July 20, 2025 at 2:18 PM
italoromeno.bsky.social
pubmed.ncbi.nlm.nih.gov/24036412/
Fosinoprilat alleviates lipopolysaccharide (LPS)-induced inflammation by inhibiting TLR4/NF-κB signaling in monocytes - PubMed
The inhibitory effect of the fosinoprilat on the TRL4/NF-κB signaling pathway reveals a potential anti-inflammatory and anti-atherosclerosis target.
pubmed.ncbi.nlm.nih.gov
July 16, 2025 at 2:01 AM
italoromeno.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC...
Doxycycline increases neurogenesis and reduces microglia in the adult hippocampus
Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process of brain plasticity involved in learning and memory. Although inducible-reversible transgenic mouse m...
pmc.ncbi.nlm.nih.gov
July 5, 2025 at 12:55 PM
italoromeno.bsky.social
onlinelibrary.wiley.com/doi/full/10....
<em>Clinical & Translational Immunology</em> | ASI Journal | Wiley Online Library
This article proposes the novel hypothesis that bipolar disorder (BD) is a chronic autoimmune disease caused by Epstein–Barr virus (EBV) infection of autoreactive B cells, which accumulate in the bra....
onlinelibrary.wiley.com
July 3, 2025 at 4:38 PM
italoromeno.bsky.social
pubmed.ncbi.nlm.nih.gov/40458637/
Anti-EBV: Artificial intelligence driven predictive modeling for repurposing drugs as potential antivirals against Epstein-Barr virus - PubMed
Epstein-Barr virus (EBV) is linked to various cancers like gastric carcinoma, nasopharyngeal carcinoma, and Burkitt's lymphoma, leading to around 200,000 deaths annually. Despite efforts, FDA-approved...
pubmed.ncbi.nlm.nih.gov
July 2, 2025 at 8:09 PM
italoromeno.bsky.social
Small Molecule Screening Identifies Inhibitors of the Epstein-Barr Virus Deubiquitinating Enzyme, BPLF1 - PMC
Small Molecule Screening Identifies Inhibitors of the Epstein-Barr Virus Deubiquitinating Enzyme, BPLF1
Herpesviral deubiquitinating enzymes (DUBs) were discovered in 2005, are highly conserved across the family, and are proving to be increasingly important players in herpesviral infection. EBV’s DUB, B...
share.google
June 28, 2025 at 8:32 PM
italoromeno.bsky.social
www.nature.com/articles/s41...
Epstein–Barr virus pathogenesis and emerging control strategies - Nature Reviews Microbiology
Sixty years after the discovery of the Epstein–Barr virus (EBV), Münz discusses new developments in the immunobiology of the first discovered human tumour virus, including vaccines and the role of EBV...
www.nature.com
June 23, 2025 at 9:56 PM
italoromeno.bsky.social
pubmed.ncbi.nlm.nih.gov/23071729/
Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice - PubMed
NADH-quinone oxidoreductase 1 (NQO1) modulates cellular NAD(+)/NADH ratio which has been associated with the aging and anti-aging mechanisms of calorie restriction (CR). Here, we demonstrate that the ...
pubmed.ncbi.nlm.nih.gov
June 19, 2025 at 11:35 AM
italoromeno.bsky.social
jneuroinflammation.biomedcentral.com/articles/10....
β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia - Journal of Neuroinflammation
Background β-Lapachone (β-LAP) is a natural naphthoquinone compound isolated from the lapacho tree (Tabebuia sp.), and it has been used for treatment of rheumatoid arthritis, infection, and cancer. In...
jneuroinflammation.biomedcentral.com
June 19, 2025 at 11:33 AM