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JAC-AMR @jac-amr.bsky.social · 20h

This study shows that more isolates of Escherichia coli, Klebsiella pneumoniae and other Enterobacterales are susceptible to amoxicillin/clavulanate than ampicillin/sulbactam:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

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JAC-AMR @jac-amr.bsky.social · 1d

Social determinants of health impact the risk of antimicrobial resistance
It’s time to refocus the research lens for knowledge, attitude and practice studies in AMR and prioritize change to address the upstream determinants:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

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JAC-AMR @jac-amr.bsky.social · 2d

Interdisciplinary approach to blood culture result management linked to decrease in mortality in community-onset S. aureus infections:
doi.org/10.1093/jaca...
@kasic.bsky.social #JACAMRNews #IDSky

doi.org

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JAC-AMR @jac-amr.bsky.social · 13d

Eravacycline: a further weapon against NDM-producing Klebsiella pneumoniae? The case of a man with surgical site infection successfully treated with eravacycline plus ceftazidime/avibactam plus aztreonam
doi.org/10.1093/jaca...
#JACAMRNews #IDSky #AMRrounds @wwrighid.bsky.social

Antibiogram showing the resistance profiles of the wound isolate (panel a) and intra-operative isolate (panel b) of NDM-producing Klebsiella pneumoniae complex according to CLSI and EUCAST interpretations for a range of antimicrobial agents, as described in Galfo et al., AMRrounds: susceptibility to the new tetracycline-derivative eravacycline of New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae complex, JAC-Antimicrobial Resistance, Volume 7, Issue 4, August 2025, dlaf153, https://doi.org/10.1093/jacamr/dlaf153

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Reposted by JAC-AMR

Global Strategy Lab @gstrategylab.bsky.social · 26d

Check out this new #SAFEAMR study published in @jac-amr.bsky.social, which examines how antimicrobial resistance #AMR is framed in global policy, and the importance of clear, targeted messaging to drive action across all sectors.

📎 Publication: bit.ly/42ekH0Z

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JAC-AMR @jac-amr.bsky.social · 16d

Study of differences in the intestinal microbiome & resistome among high-risk patients who are & are not colonized with CRE found statistically significant changes in the resistome
Longitudinally shifts were associated with antibiotic exposure
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

doi.org

JAC-AMR @jac-amr.bsky.social · 19d

Prolonged IV antibiotics aren’t just a patient safety issue - they generate considerable CO₂e
#AMS is climate action
doi.org/10.1093/jaca...
#JACAMRNews #Stewardship #Sustainability #IDSky @saiedali.bsky.social

doi.org

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JAC-AMR @jac-amr.bsky.social · 21d

This single-centre, prospective, observational pharmacokinetic study showed administering 3 g of ampicillin/sulbactam every 3 h maintained sufficient plasma concentration among adult liver transplant recipients even with excessive bleeding:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

doi.org

JAC-AMR @jac-amr.bsky.social · 23d

What is the optimal teicoplanin target for E. faecium bacteraemia? Yamaguchi et al. found a freeAUC24/MICEtest of ≥462 reduces treatment failure:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky #AMR #PKPD

doi.org

JAC-AMR @jac-amr.bsky.social · 26d

Infection with antimicrobial-resistant organisms significantly worsens outcomes in cancer patients
A survey of oncologists offers data that could support the development of oncology-specific AMS strategies and training programs:
doi.org/10.1093/jaca...
#IDSky #JACAMRNews

doi.org

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JAC-AMR @jac-amr.bsky.social · 28d

First-in-human study of the bezothiazinone and DpRE1 inhibitor, BTZ-043, a novel anti-TB drug candidate
Single ascending doses of BTZ-043 administered to healthy participants showed a good safety profile and favourable PK properties:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

doi.org

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JAC-AMR @jac-amr.bsky.social · Sep 8

Fluoroquinolone use in France dropped over the past decade amid efforts to curb resistance and side effects, but continued efforts are needed to promote safe use:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky #AntibioticStewardship #Fluoroquinolones #DrugUtilisation #France

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JAC-AMR @jac-amr.bsky.social · Sep 5

Meštrović et al. present a comprehensive set of pre-COVID-19 AMR burden estimates (deaths & DALYs) for Germany for 23 bacterial pathogens & 88 pathogen-drug combinations, and pursue comparative analysis with previous estimates
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

doi.org

JAC-AMR @jac-amr.bsky.social · Sep 3

This paper explores patients’ views of their experiences of penicillin allergy de-labelling. Their insights will be used to further optimize penicillin allergy de-labelling implementation interventions:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

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AbstractBackground. Penicillin allergy (penA) records are common, but true penA is rare. PenA records are associated with broad spectrum antibiotic prescri

doi.org

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JAC-AMR @jac-amr.bsky.social · Sep 1

New research by @evakrockow.bsky.social et al. finds #AMR messages too technical and unclear
We need clearer, more relatable comms to drive change:
doi.org/10.1093/jaca...
@evakrockow.bsky.social @bsacandjac.bsky.social #JACAMRNews #IDSky

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doi.org

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JAC-AMR @jac-amr.bsky.social · Aug 28

FI-Lab is a predictor of mortality in CDI patients and a valuable tool for early risk stratification:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

Validate User

doi.org

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JAC-AMR @jac-amr.bsky.social · Aug 26

Genomic and phenotypic analysis reveals high antimicrobial resistance in A. baumannii from combat wounds in Ukraine, posing treatment challenges:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky @bsacandjac.bsky.social

doi.org

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JAC-AMR @jac-amr.bsky.social · Aug 22

Genome report of MDR and ESBL-producing Shigella flexneri from Japan highlights antimicrobial resistance and virulence genes:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

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doi.org

JAC-AMR @jac-amr.bsky.social · Aug 20

In vivo emergence of ceftazidime/avibactam resistance in an OXA-244-positive E. coli strain, driven by a YRIK insertion in PBP3 & mutations in the AcrB efflux pump & PBP2—a multifaceted resistance mechanism beyond β-lactamase activity:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

In vivo evolution of ceftazidime–avibactam resistance in blaOXA-244-positive E. coli potentially linked to PBP3 insertion and mutations in acrB and PBP2

AbstractBackground. Ceftazidime/avibactam has been introduced as a promising treatment option against multidrug-resistant Gram-negative bacteria.Objectives

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JAC-AMR @jac-amr.bsky.social · Aug 18

Phage vB_AbaSt_W16 shows potent efficacy and favourable PK/PD profiles against CRAB infections in mice, supporting its clinical potential:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

JAC-AMR @jac-amr.bsky.social · Aug 14

During the 2023 epidemic in China, M. pneumoniae isolates were highly resistant to macrolides but susceptible to tetracycline & quinolones
To treat macrolide-resistant M. pneumoniae, tetracycline, moxifloxacin & doxycycline would be the recommended antibiotics
doi.org/10.1093/jaca...
#JACAMRNews

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JAC-AMR @jac-amr.bsky.social · Aug 13

HCV Genotype 5 & 34 Genotype 2 unclassified subtypes reported in Cameroon: no resistance mutations to NS5B polymerase inhibitor sofosbuvir—evidence that sofosbuvir-containing regimens are effective for 1st line hepatitis C treatment in Cameroon
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

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JAC-AMR @jac-amr.bsky.social · Aug 12

Paediatric antibiotic use in Belgian ambulatory care dropped sharply during the pandemic but rebounded post-pandemic, approaching pre-pandemic levels
Findings emphasize the need for continued #AntimicrobialStewardship efforts:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

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JAC-AMR @jac-amr.bsky.social · Aug 7

Aztreonam/avibactam is a potential therapeutic option for difficult-to-treat infections caused by MBL-producing Gram-negative bacteria:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

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JAC-AMR @jac-amr.bsky.social · Aug 5

Retrospective, single-centre study of adult patients with monomicrobial, uncomplicated BSI caused by AMP- or AMX-susceptible Streptococcus or Enterococcus:
No significant difference in 90-day all-cause mortality between oral switch & IV therapy groups
doi.org/10.1093/jaca...
#JACAMRNews