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The Jackson Laboratory @jacksonlab.bsky.social · 1d

Organoids and organs-on-chips bridge the gap between basic biology and human health, offering insights to scientists and more precise diagnostic and therapeutic strategies for patients. 🧬 🔬 🧪

Science in 3D: How organoids and organs-on-chips can help scientists study host-immune-microbiome interactions

Organoids and organs-on-chips bridge the gap between basic biology and human health, offering insights to scientists and more precise diagnostic and therapeutic strategies for patients.

www.jax.org

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The Jackson Laboratory @jacksonlab.bsky.social · 7d

Researchers at the Toulouse Institute for Infectious and Inflammatory Diseases characterized human mast cell development in the JAX CD34+ HSC humanized NSG-SGM3-IL15 model. Read the full publication: https://doi.org/10.1111/all.70058 & learn more by exploring the JAX HuMice Platform

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The Jackson Laboratory @jacksonlab.bsky.social · 13d

JAX researchers are training #AI to read tumor slides of rare pediatric sarcomas— delivering fast, consistent diagnoses that can lead families to better treatments, faster. 🧬 🧪

Seeing what’s hidden: Using AI to transform pediatric cancer care

Sarcomas account for only about 1% of pediatric cancers, but for the children and families who face them, that rarity makes them especially hard to diagnose.

www.jax.org

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The Jackson Laboratory @jacksonlab.bsky.social · 14d

🧪🤝🖥️ 🧬   Our buildings glow green for World Cancer Research Day—honoring the work of our scientists, including the JAX Cancer Center’s NCI rating of exceptional, and MCGI’s breakthroughs, setting a new standard for community-based oncology.

We’re proud to light the way forward in cancer research.

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Reposted by The Jackson Laboratory

JAX Genomic Education @jaxeducation.bsky.social · 19d

As National Postdoc Appreciation Week comes to a close, we’re celebrating the incredible contributions of postdocs at @jacksonlab.bsky.social and beyond.

Your work drives research and discovery forward. Thank you for your dedication and impact! 👏

#NPAW2025

www.jax.org/news-and-ins...

How JAX’s postdoctoral researchers are helping shape the future of human health

Postdoctoral fellows at The Jackson Laboratory (JAX) are at the forefront of scientific discovery, conducting cutting-edge research on complex diseases that impact the health of millions.

www.jax.org

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Reposted by The Jackson Laboratory

JAX Genomic Education @jaxeducation.bsky.social · 23d

🙌 💻 Did you know today is National #OnlineLearningDay?

Level up your genetics and genomics knowledge with @jacksonlab.bsky.social, anytime, anywhere: www.jax.org/education-an...

JAX Online MicroLessons and MiniCourses

Self-paced online learning from the genetics and genomics experts at The Jackson Laboratory, designed for graduate students, postdocs, research assistants, early career scientists, lab technicians and...

www.jax.org

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The Jackson Laboratory @jacksonlab.bsky.social · 26d

A partnership between JAX and the Connecticut Children’s Research Institute sets out to tackle pediatric intestinal inflammatory diseases (including Crohn’s disease, ulcerative colitis, eosinophilic esophagitis, and celiac disease) in innovative new ways. 🧬🧪 #medsky

JAX and Connecticut Children’s Research Institute Launch Collaboration to Advance Pediatric Gut Health

Collaborative initiative integrates clinical insight and cutting-edge holistic, human-relevant models to transform care

www.jax.org

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The Jackson Laboratory @jacksonlab.bsky.social · 27d

An unusual therapy developed at The Jackson Laboratory (JAX) could change the way the world fights influenza, one of the deadliest infectious diseases. 🧬🧪

A ‘universal’ therapy against the seasonal flu? Antibody cocktail targets virus weak spot

Unusual immune strategy protects against all tested flu strains and prevents viral escape

www.jax.org

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The Jackson Laboratory @jacksonlab.bsky.social · 28d

Same mission. Different methods. Radiation, chemo, immunotherapy—each fights cancer in its own way.

Want to understand how? 🎬 5 minutes of the basics: https://youtu.be/cT3E1OzxZnY

Discover more resources just like this: www.jax.org/patients

Reposted by The Jackson Laboratory

JAX Genomic Education @jaxeducation.bsky.social · Sep 8

🖥️ 🧬 UNDERGRADS: Take your #DataScience skills to the next level!

Applications are open for @jacksonlab.bsky.social's 2026 Biomedical Data Science in Context program, taking place January 3 – 17 at our campus in Bar Harbor, Maine.

💡 Questions? Join an info session to learn more: www.jax.org/bdsic

Info sessions for undergrads. Biomedical Data Science in Context. Learn how this experiential program can help you build data science skills and confidence through hands-on training and mentorship. September 30 or October 8 at 7 p.m. ET. Virtual (Zoom). Register at jax.org/bdsic.

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The Jackson Laboratory @jacksonlab.bsky.social · Sep 5

Organoids and organs-on-chips bridge the gap between basic biology and human health, offering insights to scientists and more precise diagnostic and therapeutic strategies for patients. 🧬🧪

Science in 3D: How organoids and organs-on-chips can help scientists study host-immune-microbiome interactions

Organoids and organs-on-chips bridge the gap between basic biology and human health, offering insights to scientists and more precise diagnostic and therapeutic strategies for patients.

www.jax.org

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The Jackson Laboratory @jacksonlab.bsky.social · Sep 4

The MorPhiC consortium — a program led in part by JAX scientists — aims to better understand the function of every human gene and generate a catalogue of the molecular and cellular consequences of inactivating genes. 🧪 🧬

https://youtu.be/5NfDpH9zVic

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The Jackson Laboratory @jacksonlab.bsky.social · Aug 29

As part of the MorPHic project, JAX is helping create a first-of-its-kind atlas of gene function that could transform our understanding of development, disease, and precision medicine. 🧬🧪 https://www.jax.org/news-and-insights/2025/august/morphic-cellular-modeling-at-scale

MorPhiC: Cellular modeling at scale

JAX plays key role in national effort to decode the function of every human gene.

www.jax.org

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The Jackson Laboratory @jacksonlab.bsky.social · Aug 27

Could routine eye exams reveal early signs of Alzheimer’s? New findings from The Jackson Laboratory (JAX) strengthen the link between retinal health and early dementia risk. 🧬 🧪 🧠 👁️

Could routine eye exams reveal early signs of Alzheimer’s?

New findings strengthen the link between retinal health and early dementia risk.

www.jax.org

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The Jackson Laboratory @jacksonlab.bsky.social · Aug 21

JAX research roundup: hidden DNA, genome editing and more — With #AI and next-generation genome editing, JAX scientists are paving the way for the future of precision medicine. 🧬 🧪 🔬

Catch up on some notable JAX news you may have missed!

JAX research roundup: hidden DNA, genome editing, and more

With artificial intelligence and next-generation genome editing, JAX scientists are paving the way for the future of precision medicine. Here is some notable news you may have missed.

www.jax.org

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The Jackson Laboratory @jacksonlab.bsky.social · Aug 19

Learn more:
www.jax.org/news-and-ins...

Study uncovers molecular “switch” behind chemoresistance in blood cancer

JAX scientists are beginning to understand how RNA biology affects resistance to chemotherapy in acute myeloid leukemia.

www.jax.org

The Jackson Laboratory @jacksonlab.bsky.social · Aug 19

In this state, cancer cells effectively hide from chemotherapy, which works best when cancer cells are actively dividing. In other words, dormant cancer cells go unnoticed and can “wake up” after treatment.

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The Jackson Laboratory @jacksonlab.bsky.social · Aug 19

Specifically, RUNX1C turned on a gene called BTG2. This interfered with the cells’ RNA, slowing down cell activity and pushing leukemia cells into a dormant or quiescent state where they stop dividing.

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The Jackson Laboratory @jacksonlab.bsky.social · Aug 19

That small change flipped a genetic switch, forcing cancer cells to make more of the RUNX1C isoform, activating a mechanism that made them far better at withstanding chemotherapy.

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The Jackson Laboratory @jacksonlab.bsky.social · Aug 19

By studying data from AML patients from before they received chemotherapy and again after their cancer returned, the team found that in many cases a chemical tag known as DNA methylation had appeared in a section of the genome that normally controls the RUNX1 gene.

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The Jackson Laboratory @jacksonlab.bsky.social · Aug 19

A team led by JAX Assistant Professor Eric Wang reported on the role of a protein called RUNX1C in this mechanism. A little-known variation, or “isoform” of a gene called RUNX1, the RUNX1C protein helps regulate how blood cells resist chemotherapy.

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The Jackson Laboratory @jacksonlab.bsky.social · Aug 19

New research from the Wang Lab at The Jackson Laboratory (JAX) points to a previously unknown molecular mechanism behind that chemoresistance... and a way to potentially disarm it.

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The Jackson Laboratory @jacksonlab.bsky.social · Aug 19

One of the biggest challenges in cancer treatment is that certain cancers reappear after chemotherapy — acute myeloid leukemia (#AML), an aggressive type of blood cancer, is notorious for this.

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The Jackson Laboratory @jacksonlab.bsky.social · Aug 19

JAX scientists are beginning to understand how #RNA biology affects resistance to #chemotherapy in acute myeloid leukemia. 🧪🧬🔬

Study uncovers molecular “switch” behind chemoresistance in blood cancer

JAX scientists are beginning to understand how RNA biology affects resistance to chemotherapy in acute myeloid leukemia.

www.jax.org

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Reposted by The Jackson Laboratory

The Jackson Laboratory @jacksonlab.bsky.social · Jul 25

Hope could be in sight for sufferers of myalgic encephalomyelitis/chronic fatigue syndrome #MECFS and long COVID.

New research shows how the gut microbiome may predict these so-called "invisible" diseases, which are notoriously hard to diagnose.

🧪🧬 #medicine

Gut microbiome may predict invisible chronic fatigue syndrome and long COVID

Previously undetectable biomarkers in gut bacteria, immune responses, and metabolism offer hope for future diagnostic tools.

www.jax.org

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