Eric Peterman @errricpeterman.bsky.social, Jeffrey Rasmussen @jraslab.bsky.social @uwbiology.bsky.social & colleagues discover that microtubules regulate tissue-level navigation in skin-resident macrophages.
journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

Academic authors, here's a peek into the black box of journal publishing from an journal editor if you can bear it:

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com)‬ paper, Miranda Hunter (@mrndhntr.bsky.social‬) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

Had thought to test this wild idea in the future but so cool to see Francesca Peri lab making it real: Xenografted human microglia in zebrafish, doing their job 😍https://www.biorxiv.org/content/10.1101/2025.08.27.672578v1.full.pdf

🐟 Zebrafish (Danio rerio): Clear as glass, zebrafish embryos let you watch organs form in real time. A powerhouse for studying organogenesis and regeneration, they’re also champions of transgenic expression of fluorescent proteins 🌈 image from Gopi Shah 🧪 #ModelMonday #DevBio

But not right away at least. And they do not seems to be too unhappy even when stuck with them😉

Repulsive and attractive cues team up to sculpt the retina🔧👁️, Perfect positioning also for your neurons navigating in multipolar manner, no GPS required! Get your free pdf copy of the full story today: www.biorxiv.org/cgi/content/...

2. Attraction through Gfrα1 receptor (HC) and Neurturin secreted from apical photoreceptors.
-Weaker cue ensuring HCs reach the photoreceptors. Take both Neurturin and Robo2 out and majority of HCs (cyan + yellow) are misplaced in the amacrine cell layer (yellow).

1. Repulsion through Robo2 receptor (HC) and Slit1b/2, expressed by the basal amacrine cells (yellow).
-Without Robo2 HCs (cyan + yellow), especially the ones further away from photoreceptor cell layer (grey arrowheads), fail to laminate correctly.

So, what is going on? 🤔 Using transcriptomics, in vivo CRISPR screens and high-res live imaging in a transparent zebrafish retina 👁️, we now introduce “The Spatiotemporal Guidance System🗺️⏰” for multipolar migration with dual action:

But how then to know where to go? A problem many developing neurons face, including the retinal horizontal cells (HCs), we studied.
Neighboring cells as tracks? Removing 3/4 retinal cell types and HCs still navigate correctly. However, take out the 4th type (amacrine cells) and 💥 HCs are stuck.

Interested in cell migration yet bored of the canonical translocation modes? 😴 Don’t worry — we @nordenlab.bsky.social with @aiopticalbiolab.bsky.social have multipolar migration back in stock! No need to follow the other cells: extend long protrusions and roam more freely🪼 in the crowded brain.

Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!

Skimming through biorxiv might improve your climbing?

As a non-expert (climber and in this field), I was taught to climb the route mentally before physically. Movement coordination comes through repetitions as in any sport.🤔

Ever wondered how to manipulate mechanical forces in the developing zebrafish heart?🤓

Check out our new protocol by @cvagenapantoula.bsky.social and Hajime, where we describe magnetic bead grafting as an effective approach to study #mechanotransduction!🐟🔬

app.jove.com/t/67604/mani...

Also thrilled to start today a new chapter in @guijacquemet.bsky.social lab on microglia migration and their protrusion dynamics🧠🐠

After ~3.5 inspiring years @nordenlab.bsky.social, I’ve migrated back to 'apical' Finland. The last months, I appeared a lot like these multipolar retinal cells. Excited to share more soon about their fascinating in vivo navigation!