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JAMA Cardiology @jamacardiology.com · 15h

Integrating common, rare, and somatic genetic variants with clinical factors improves risk prediction for incident atrial fibrillation, aiding screening and prevention efforts.

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Figure 1 shows the carrier status of rare variants linked to Atrial Fibrillation (AF). Two bar graphs display 'Carrier No.' vs 'Genes'. Graph A charts 'AFgeneset' genes, while Graph B focuses on 'CHIP-associated genes.'

JAMA Cardiology @jamacardiology.com · 15h

RCT: Intracardiac echocardiography is non-inferior to transesophageal echocardiography for thromboembolic prevention in atrial fibrillation ablation, with added benefits in safety, efficiency, and patient comfort.

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JAMA Cardiology graphic: RCT comparing Intracardiac vs Transesophageal Echocardiography in Atrial Fibrillation Ablation. Population: 942 men, 868 women. Intervention: 1810 patients randomized. Findings: ICE noninferior to TEE. Settings: 10 hospitals, China.

JAMA Cardiology @jamacardiology.com · 18h

Invited Commentary: In their study, Jhee et al show that maintaining strong #cardiovascular health in young adulthood substantially decreases midlife risks for cardiovascular and kidney diseases.

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An article titled 'How Cardiovascular Health in Young Adulthood Affects Kidney and Cardiovascular Risk Later in Life—Lifespan Lessons' by Sarah Haeger, MD, PhD; Nisha Bansal, MD, MAS.

JAMA Cardiology @jamacardiology.com · 19h

A higher cumulative #cardiovascular health score from 30 to 40 years of age was associated with markedly lower risks of CVD and kidney events in midlife.

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Figure shows risk of CVD and kidney events from ages 30-40 based on CVH score. Hazard ratios decline as CVH score increases, plotted for CVD events, kidney events, and either CVD or kidney events.

JAMA Cardiology @jamacardiology.com · 1d

Persistent underrepresentation in cardiovascular clinical trials undermines generalizability and equitable care. This review provides a strategic framework to enhance representation.

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Table outlining timelines, policy names, and relevance summaries for enhancing representative participation in trials. Includes executive orders, FDA & NIH strategic plans related to diversity, equity, inclusion, and accessibility (DEIA).

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JAMA Cardiology @jamacardiology.com · 2d

Invited Commentary: In their study, Jhee et al show that maintaining strong #cardiovascular health in young adulthood substantially decreases midlife risks for cardiovascular and kidney diseases.

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JAMA Cardiology @jamacardiology.com · 2d

A higher cumulative #cardiovascular health score from 30 to 40 years of age was associated with markedly lower risks of CVD and kidney events in midlife.

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JAMA Cardiology @jamacardiology.com · 2d

In this cohort and nested case-control study, moderate to vigorous–intensity physical activity declined from early adulthood to midlife, with further drops pre- and post-cardiovascular events. ja.ma/3Vc7EcG

Trajectories of Physical Activity Before and After Cardiovascular Disease Events in CARDIA Participants

This cohort and nested case-control study among CARDIA (Coronary Artery Risk Development in Young Adults) participants evaluates trajectories of moderate to vigorous physical activity across adulthood, before and after cardiovascular disease, and by demographic variations.

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JAMA Cardiology @jamacardiology.com · 4d

Preoperative cardiovascular risk did not affect outcomes related to continuing vs discontinuing RAS inhibitors before major noncardiac surgery. ja.ma/4mTltZ1

JAMA Cardiology brief report: "Preoperative Cardiovascular Risk and Postoperative Outcomes by Renin-Angiotensin System Inhibitor Use". Authors: Justine Tang, Romain Pirracchio, Bernard Cholley, et al. Published online June 25, 2025.

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JAMA Cardiology @jamacardiology.com · 4d

In a binational study of older adults with #diabetes, nearly 60% in the US and 31% in Japan discontinued #GLP-1RAs within 12 months of starting injectable #semaglutide.

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Figure 1 shows bar graphs and lines depicting the annual volume of TAVR procedures. A-TAVR procedures from 2012-2024. B-Total TAVR reintervention procedures. C-Redo-TAVR procedures. D-TAVR explant procedures.

JAMA Cardiology @jamacardiology.com · 4d

PREVENT risk age equations show U.S. adults typically have a higher risk age than chronological age, offering a tool to improve communication for cardiovascular disease prevention. ja.ma/46SfiOG

Bar graphs show discordance between chronological and PREVENT risk age in the US, by sex. For women, the number of individuals whose risk age is >10 years older decreases with age. Men have higher numbers whose risk age is >5 years younger.

JAMA Cardiology @jamacardiology.com · 5d

Invited Commentary: In their study, Jhee et al show that maintaining strong #cardiovascular health in young adulthood substantially decreases midlife risks for cardiovascular and kidney diseases.

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JAMA Cardiology @jamacardiology.com · 5d

A higher cumulative #cardiovascular health score from 30 to 40 years of age was associated with markedly lower risks of CVD and kidney events in midlife.

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JAMA Cardiology @jamacardiology.com · 7d

Patients with peripartum, alcohol-induced, and cancer therapy–related cardiomyopathies had enriched monogenic variants and high polygenic risk scores for dilated cardiomyopathy, indicating shared genetic susceptibility.

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Figure 1 shows the distribution of participants by the number of antecedent clinical risk factors for cardiomyopathy. It's a bar graph comparing PPCM, ACM, and CCM with risk factors 0, 1, 2, and 3.

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JAMA Cardiology @jamacardiology.com · 7d

Invited Commentary: In their study, Jhee et al show that maintaining strong #cardiovascular health in young adulthood substantially decreases midlife risks for cardiovascular and kidney diseases.

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JAMA Cardiology @jamacardiology.com · 7d

A higher cumulative #cardiovascular health score from 30 to 40 years of age was associated with markedly lower risks of CVD and kidney events in midlife.

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JAMA Cardiology @jamacardiology.com · 8d

EAST-AFNET 4 RCT: Early rhythm control therapy is effective and safe for treating atrial fibrillation in patients with and without #obesity or #diabetes. ja.ma/47AT3Pn

Diabetes and Obesity and Treatment Effect of Early Rhythm Control vs Usual Care in Atrial Fibrillation

This secondary analysis of the EAST-AFNET 4 randomized clinical trial assesses the effects of body mass index and diabetes on outcomes in EAST-AFNET 4.

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JAMA Cardiology @jamacardiology.com · 9d

From 2001 to 2020 in King County, Washington, out-of-hospital #cardiacarrest incidence showed varied temporal patterns across subgroups, while overall survival rates improved. ja.ma/46TqcoF

Three line graphs showing OHCA incidence from 2001 to 2020. Graph A shows "All-rhythm OHCA incidence", B shows "Shockable rhythm OHCA incidence", and C shows "Nonshockable rhythm OHCA incidence", each broken down by sex and age groups.

JAMA Cardiology @jamacardiology.com · 12d

A previously healthy 55-year-old man presented to his local family medicine clinic after waking up with a buzzing sensation in his chest. What would you do next?

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Medical imaging shows phonocardiogram with S1, S2, murmur labels, an abdominal aorta pulse wave Doppler with retrograde flow arrowheads, and a transesophageal echocardiography of the aortic valve in long axis.

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JAMA Cardiology @jamacardiology.com · 13d

In a binational study of older adults with diabetes, nearly 60% in the US and 31% in Japan discontinued #GLP-1RAs within 12 months of starting injectable #semaglutide, with higher discontinuation among those with cardiovascular disease or chronic kidney disease.

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JAMA Cardiology @jamacardiology.com · 13d

In a national US analysis of TAVR procedures from 2012 to 2024, annual volumes of redo TAVR and TAVR explant increased, TAVR reintervention beyond 5 years is predominantly performed via redo TAVR.

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A research letter titled "Discontinuation of Semaglutide Among Older Adults With Diabetes in the US and Japan", followed by a table comparing patient characteristics in the US and Japan.

JAMA Cardiology @jamacardiology.com · 15d

An intervention that combined team-based primary care with automated identification of patients with antihypertensive medication nonadherence did not lead to improvements in adherence or blood pressure. ja.ma/3IDVw1k

JAMA Cardiology study on medication adherence in hypertension, comparing a multicomponent intervention vs. usual care. Key findings: no significant difference in antihypertensive medication adherence between the groups.

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JAMA Cardiology @jamacardiology.com · 16d

In a nationwide study of outpatients with heart failure, a majority eligible for SGLT2i therapy did not receive it, particularly those who were older, female, or with higher blood pressure. ja.ma/4nA6GDa

Graph showing practice-level variation in percentage of patients prescribed Sodium-Glucose Cotransporter 2 Inhibitor, or SGLT2i. It shows an increasing trend between practice and patients prescribed.

JAMA Cardiology @jamacardiology.com · 17d

Case report: a diagnosis of patent foramen ovale in a man in his 60s presenting with stroke symptoms and multifocal infarcts on magnetic resonance imaging of the brain. ja.ma/41GLz9R

Patent Foramen Ovale and Dysarthria in a Man in His 60s

This case report describes a diagnosis of patent foramen ovale in a man in his 60s presenting with stroke symptoms and multifocal infarcts on magnetic resonance imaging of the brain.

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JAMA Cardiology @jamacardiology.com · 18d

PREVENT risk age equations show U.S. adults typically have a higher risk age than chronological age, offering a tool to improve communication for cardiovascular disease prevention. ja.ma/4nKkT0x

Two bar graphs compare chronological age vs. cardiovascular risk age in the US population by sex. Graph A shows women, and Graph B shows men. Bars are segmented to show age discordance ( >5y younger, within 5y, 5-10y older, >10y older)