Lightnews — Scholar-powered news

JAMA Internal Medicine @jamainternalmed.com · 20h

Only 4 US states comprehensively regulate IV hydration spa governance, prescriber credentials, dispensing, and compounding practices.

ja.ma/48jpG4v

Map of the USA showing state-level policies for intravenous hydration spas. States are shaded or patterned to represent guidelines on dispensing, governance, prescribing, and compounding, with Alaska and Hawaii shown as insets.

1 1

JAMA Internal Medicine @jamainternalmed.com · 22h

This Teachable Moment describes a patient in their 60s with severe alcohol use disorder and alcohol-induced cirrhosis complicated by ascites who presented with an altered mental status.

ja.ma/4gZwtTb

JAMA Internal Medicine article titled, "A Case for Early High-Dose Thiamine—Moving From Reaction to Prevention," by Douglas N. Goldstein, Alan J. Hunter, and Patricio A. Riquelme. Published online: October 6, 2025.

1

JAMA Internal Medicine @jamainternalmed.com · 1d

Viewpoint: The Fifth Amendment ensures due process protections for acute medical care of immigration detainees; differential treatment based on custody is not justified.

ja.ma/47cMVvZ

JAMA Internal Medicine article titled "Rights of Immigration Detainees to Acute Medical Care" by Lawrence A. Haber, Hans P. Erickson, and Peter L. Markowitz, published online October 6, 2025.

JAMA Internal Medicine @jamainternalmed.com · 2d

Today the JAMA Internal Medicine editorial board met to discuss goals for the journal, which is dedicated to providing innovative and clinically relevant research for the field of internal medicine.

Watch this space for the latest updates.

JAMA Internal Medicine @jamainternalmed.com · 2d

This JAMA Internal Medicine Patient Page describes dense breasts and whether they might lead to higher risk for #BreastCancer.

ja.ma/3Wtbs9S

Diagram showing dense versus nondense breasts with labeled tissues. Below are mammogram images showing classifications from almost entirely fatty to extremely dense with noted cancer.

1

JAMA Internal Medicine @jamainternalmed.com · 2d

Only 4 US states comprehensively regulate IV hydration spa governance, prescriber credentials, dispensing, and compounding practices.

ja.ma/4pUxsYU

1

JAMA Internal Medicine @jamainternalmed.com · 3d

Among medical students with disabilities, 12.4% reported experiencing discrimination, with the highest rates among those with chronic illness, motor or sensory disabilities, and multiple disabilities. ja.ma/4mKkmKT

A JAMA Internal Medicine research letter titled "Prevalence and Sources of Disability-Based Discrimination in a National Sample of Graduating Medical Students" by Mytien Nguyen et al. Published online July 28, 2025.

JAMA Internal Medicine @jamainternalmed.com · 4d

Vancomycin in midline catheters for outpatient therapy was associated with increased risks of bloodstream infections, venous thromboembolism, and device failure compared to other treatments. ja.ma/3WnffFM

Two graphs display cumulative hazard curves for OPAT patients with midline catheters, comparing vancomycin receipt vs. no vancomycin. Graph A shows major device complications, Graph B shows device failure, over 30 days.

1 1 1

JAMA Internal Medicine @jamainternalmed.com · 5d

Among FDA anticancer drug approvals from 2009 to 2020, only 27 next-in-class drugs had direct randomized clinical trial comparisons with first-in-class drugs. ja.ma/4q79RV8

Network diagram of randomized clinical trials testing anticancer drugs. Categories include small-molecule inhibitors, chemotherapies, monoclonal antibodies, androgen inhibitors, and immunomodulatory agents, with connecting arrows.

JAMA Internal Medicine @jamainternalmed.com · 6d

Between 2020 and 2023, out-of-sequence kidney transplants in the U.S. increased without corresponding reductions in organ discard rates. ja.ma/46wxC11

JAMA Internal Medicine article: Socioeconomic Disparities in Out-of-Sequence Placement of Deceased Donor Kidneys in the US by Sumit Mohan et al. Published July 7, 2025.

1

JAMA Internal Medicine @jamainternalmed.com · 8d

💬 @jama.com Perspective: The evaluation of moderate alcohol consumption on health is complex due to known harms of heavy drinking, potential benefits of low consumption, varying evidence quality, and biases.

ja.ma/4nXpNHB

A JAMA article titled "The Complexity of Research on Moderate Alcohol Consumption and Health: The Consensus Report From NASEM" by Ned Calonge et al., published online September 30, 2025.

JAMA Internal Medicine @jamainternalmed.com · 9d

PREVENT risk equations identify fewer adults aged 40–59 as aspirin-eligible for primary ASCVD prevention than PCEs.

ja.ma/4h3jxfj

Two bar graphs compare eligibility for primary prevention aspirin in US adults aged 40-59. Graph A shows eligibility by risk calculator (PCES vs. PREVENT) across age, sex, race, and comorbidities. Graph B shows adults eligible by PCEs but not PREVENT.

JAMA Internal Medicine @jamainternalmed.com · 9d

Special Communication: Doubling of early-onset cancer incidence since 1992 in US adults <50 reflects increased diagnosis; mortality remains stable or declines.

ja.ma/46HkfK8

The image shows two line graphs comparing cancer diagnoses and mortality from 1990-2025. The first graph shows the incidence of thyroid, colorectal, endometrial, kidney, anal, pancreatic, myeloma and small intestinal cancers. The second graph shows cancer mortality.

1

JAMA Internal Medicine @jamainternalmed.com · 11d

The Patient Driven Payment Model was associated with increased coding intensity and Medicare expenditures in skilled nursing facilities, especially for medically complex patients, without affecting rehospitalization or mortality rates. ja.ma/42O774P

Line graph showing changes in coding intensity before and after PDPM implementation. The x-axis is 'Admission date relative to October 2019, d,' and the y-axis is 'Elixhauser Comorbidity Index score'. Lines represent data for Hospitals and SNFs.

1

JAMA Internal Medicine @jamainternalmed.com · 11d

This Guide to Statistics and Methods explains how covariate-constrained randomization (CCR) enhances rigor in cluster randomized clinical trials. ja.ma/3ICwGz1

Covariate-Constrained Randomization (CCR) is illustrated. Section A shows all ways to allocate practices across study arms. Section B shows constrained randomization space. Rural (A, B) and Urban (C, D) practices are randomized.

3

JAMA Internal Medicine @jamainternalmed.com · 14d

In adults with acute mild to moderate #COVID19, metformin did not shorten recovery time compared to placebo, with similar median times to symptom resolution in both groups. ja.ma/3UWpQHi

Metformin and Time to Sustained Recovery in Adults With COVID-19

This randomized clinical trial examines metformin compared with placebo for symptom resolution during acute infection with SARS-CoV-2.

ja.ma

1

JAMA Internal Medicine @jamainternalmed.com · 16d

In the latest episode of JAMA Internal Medicine Author Interviews, author Sammy Saab, MD, MPH, and guest expert Guadalupe Garcia-Tsao, MD, discuss metabolic-associated steatotic liver disease with Eve Rittenberg, MD.

Listen now: ja.ma/4pxWbSy

Targeting MASLD and MASH in the US Hispanic/Latino Population

Interview with Sammy Saab, MD, MPH, author of Targeting MASLD and MASH in the US Hispanic/Latino Population: A Review. Hosted by Eve Rittenberg, MD.

ja.ma

1 1

JAMA Internal Medicine @jamainternalmed.com · 16d

This Review explores the factors that predispose Hispanic/Latino patients to metabolic dysfunction–associated steatotic liver disease and metabolic dysfunction–associated steatohepatitis.

ja.ma/4nlpAhp

Figure 2: Interventions for Hispanic/Latino patients with MASLD/MASH, focusing on social support (SNAP, WIC), multidisciplinary care (nutrition), and medications (Glucagon, Resmetirom). It emphasizes tailored social services and community health workers.

1 1

JAMA Internal Medicine @jamainternalmed.com · 16d

Cognitive behavioral therapy for #insomnia was associated with improvements in insomnia severity, sleep efficiency, and sleep onset latency, with high treatment acceptability.

ja.ma/3Ium59e

Research article titled: Cognitive Behavioral Therapy for Insomnia in People With Chronic Disease: A Systematic Review and Meta-Analysis. It highlights the importance, objective, data sources, and results of the study.

JAMA Internal Medicine @jamainternalmed.com · 17d

Viewpoint: While the Inflation Reduction Act may initially lower anticancer drug costs, long-term spending could increase due to improved affordability and mandatory coverage. ja.ma/46SMkhZ

A bar graph compares estimated spending on the top 25 anticancer drugs under the status quo vs. under Medicare price negotiation by 2022 gross spending. '2025 Prices' are shown alongside 'Negotiated prices'.

JAMA Internal Medicine @jamainternalmed.com · 19d

Integrating lifestyle factors like diet and physical activity with #GLP1 receptor agonists is essential for managing symptoms, maintaining nutrition, preserving lean mass, and promoting regular physical activity. ja.ma/4nEsmhB

A pie chart titled, "Integrating Nutrition and Physical Activity with GLP-1 and Dual Receptor Agonist Therapy." It details dietary recommendations, including hydration, micronutrients, fruits, protein, healthy fats, and whole grains.

1 1

JAMA Internal Medicine @jamainternalmed.com · 20d

A nurse-led, interprofessional family support intervention in ICUs showed improvements in family satisfaction, communication quality, and cognitive and emotional support for families of critically ill patients. ja.ma/47NoC8V

JAMA Internal Medicine visual abstract: RCT: Nurse-Led Family Support Intervention for Families of Critically Ill Patients. Population: 281 Men, 568 Women, 36 Other/unknown. Findings: family support intervention had statistically significant improvements.

1

JAMA Internal Medicine @jamainternalmed.com · 21d

First-year over-the-counter naloxone sales showed limited uptake and did not effectively bridge gaps from pharmacy or distribution programs, likely due to high prices. ja.ma/46lB1yw

A graph titled 'Mean Over-the-Counter Naloxone Units Sold per Million Residents in the Continental US States From September 2, 2023, to September 28, 2024' shows units sold per million residents (biweekly) over time.

1

JAMA Internal Medicine @jamainternalmed.com · 22d

#HormoneTherapy reduces vasomotor symptoms w/o increasing #cardiovascular risk in postmenopausal women aged 50 to 59, but raises cardiovascular risk in those over 70, finds this secondary analysis of 2 RCTs. ja.ma/41TpDIG

Graph: Hormone therapy's influence on vasomotor symptoms (VMS), stratified by age (50-79). Y-axis: % participants with moderate/severe VMS. X-axis: Baseline & Year 1. HT & placebo results shown. All groups saw reduction in VMS from baseline to year 1.

2

JAMA Internal Medicine @jamainternalmed.com · 23d

From @jama.com: Centralizing data from diverse reporting systems enables timely, actionable measles surveillance, helping guide public health interventions, improve vaccination efforts, and model outbreak risk more precisely within communities.

ja.ma/46nWgQ7

JAMA research letter, published online September 15, 2025, shows county-level measles cases in the US. 'A' plots cumulative measles cases reported in the US in 2025, differentiating between imported (red) and local (blue) cases with varying circle sizes. Key locations: Los Angeles, New York.