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JAMA Neurology @jamaneurology.com · 1m

Viewpoint: The APOE4 allele is associated with an increased risk of #Alzheimer disease and earlier onset, but more longitudinal studies with diverse populations are needed to accurately estimate this risk.

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JAMA Neurology viewpoint: "The Risk of Alzheimer Disease in APOE4 Homozygotes" by Eric M. Reiman, Valentina Ghisays, and Jessica B. Langbaum, published online April 14, 2025.

JAMA Neurology @jamaneurology.com · 2d

In patients with post-dural puncture headache who do not respond to conventional treatment, iatrogenic CSF-venous fistula should be considered as it may necessitate different treatment. ja.ma/48ecrCd

Figure 2. shows myelographic evidence of Transosseous Cerebrospinal Fluid(CSF) - Venous Fistula. A: CVF at initial needle position, with arrows. B: Delayed CT image showing resolution of fistula.

JAMA Neurology @jamaneurology.com · 3d

Brain arteriovenous malformations, also known as AVMs, are high flow cerebrovascular lesions with great potential to cause intracranial hemorrhage and epilepsy.

Learn more in this episode with author Helen Kim, PhD, and JAMA Neurology Web Editor Cynthia Armand.

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Hemorrhage and Risk Factors in Unruptured Brain AVM

Interview with Helen Kim, PhD, author of Risk of Future Hemorrhage From Unruptured Brain Arteriovenous Malformations: The Multicenter Arteriovenous Malformation Research Study (MARS). Hosted by Cynthia E. Armand, MD.

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JAMA Neurology @jamaneurology.com · 3d

The annual rate of first intracranial hemorrhage from unruptured brain AVMs was 1.4% in a multinational cohort, lower than commonly cited estimates.

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Kaplan-Meier survival curve showing the probability of hemorrhage over time since diagnosis of brain arteriovenous malformation. The curve rises from 0 to around 0.25 over 20 years, with a shaded area indicating the confidence interval.

JAMA Neurology @jamaneurology.com · 3d

Editorial: The ATIS-NVAF trial shows adding antiplatelet therapy to OAC in stroke patients with AF and atherosclerotic disease increases major bleeding without significant reduction in ischemic events.

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An editorial titled "Anticoagulation and Antiplatelet Therapy in Patients With Atrial Fibrillation and Atherosclerosis" by Richard A. Bernstein, MD, PhD; Lauren E. Previch, MD. The article discusses guidelines and treatments for stroke prevention.

JAMA Neurology @jamaneurology.com · 3d

In patients with ischemic stroke and concurrent nonvalvular atrial fibrillation and ASCVD, adding an antiplatelet agent to anticoagulant therapy offered no net clinical benefit over anticoagulant monotherapy.

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JAMA Neurology study: Optimal antithrombotics for ischemic stroke, atrial fibrillation, atherosclerosis. 316 patients analyzed. Findings: Antiplatelet agent didn't improve anticoagulant therapy. Graph shows cumulative event probability.

JAMA Neurology @jamaneurology.com · 5d

The VasCog-2-WSO criteria provide updated international guidelines for diagnosing vascular cognitive impairment and #dementia, incorporating recent biomarker advancements. ja.ma/4mOsJVY

JAMA Neurology article, "Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria." Published online September 16, 2025. Free article.

JAMA Neurology @jamaneurology.com · 8d

Case report: brain imaging of 2 patients with a disease course suggestive of autoimmune glial fibrillary acidic protein astrocytopathy. ja.ma/42IlRT1

Two brain scans are placed side by side. On the left, scan A: "T1 gradient echo gadolinium-enhanced sequence". On the right, scan B: "T1 spin echo gadolinium-enhanced sequence". Each shows a horizontal cross-section of a brain.

JAMA Neurology @jamaneurology.com · 10d

Case report: a patient with X-linked FHL1-related myofibrillar myopathy and Charcot-Marie-Tooth disease type 1A, a dual pathology revealed by imaging and genetic testing. ja.ma/3VXzdad

Axial T1-Weighted Magnetic Resonance Imaging of Pelvic Girdle and Thigh Muscles. The image contains two parts: (A) Pelvic girdle with yellow arrowheads and a white arrowhead, (B) Thigh muscles with a yellow arrowhead.

JAMA Neurology @jamaneurology.com · 10d

"The book is not closed on a more expansive view of the entire menopausal transition."

Learn more in this Editorial. ja.ma/46o48SW

An article titled 'Rethinking the Menopause Transition and Multiple Sclerosis Progression' by Jennifer S. Graves, MD, PhD, MAS; Mar Tintoré, MD, PhD. The article discusses the link between menopause and MS progression.

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JAMA Neurology @jamaneurology.com · 10d

In this study, menopause was not the primary driver of multiple sclerosis clinical progression in women at midlife.

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Figure 2. Predicted Extended Disability Status Scale (EDSS) Inflection Point Analysis. Graph shows EDSS score vs. time since menopause in years, with data points and trend lines indicating a correlation between menopause and disability status.

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JAMA Neurology @jamaneurology.com · 12d

OTOF gene therapy (GT) offers rapid improvements in auditory and speech performance, outperforming cochlear implantation (CI) in speech in noise and music perception.

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Figure with plots of event-related potentials for standard, deviant stimuli and mismatch negativity(MMN) at Fz Electrode. Includes graphs of MMN latency and amplitude, comparing GT vs. matched CI at 3, 6, and 12 months.

JAMA Neurology @jamaneurology.com · 12d

Local visual interpretations of clinical amyloid-PET scans closely matched central quantitative assessments, supporting the reliability of visual reads in real-world clinical settings. ja.ma/48CkQPT

Figure 4. Exploratory Data-Driven Centiloid (CL) Thresholds contains 4 graphs: Cohen к for visual-quantitative concordance; ROC predicting visual read outcome; Indices of the CL-visual read ROC; Inset of panel C graph indicated by square.

JAMA Neurology @jamaneurology.com · 14d

CT perfusion and CT angiography showed less than optimal accuracy for confirming death by neurologic criteria.

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JAMA Neurology article: "Computed Tomography Perfusion and Angiography for Death by Neurologic Criteria" by Michaël Chassé et al. Published online June 13, 2025. DOI: 10.1001/jamaneurol.2025.2375

JAMA Neurology @jamaneurology.com · 17d

Long-term adaptive deep brain stimulation (aDBS) provided tolerable, effective, and safe therapy in persons with Parkinson disease whose symptoms were previously stable while receiving continuous DBS. ja.ma/4pEY5RF

Four graphs titled 'Changes in Motor Diary'. The first two are scatter plots of 'Change in on-time, h/d' for ST and DT ADBS. The next two are bar graphs comparing 'Observed mean time, h/d' for cDBS baseline with ST and DT aDBS, including categories like 'Asleep' and 'Off-time'.

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JAMA Neurology @jamaneurology.com · 19d

Laser interstitial thermal therapy may be considered as a treatment option for durable seizure control and quality of life improvements in patients with mesial temporal lobe epilepsy. ja.ma/47LKm4W

Two bar graphs titled "Figure 1. Post-Laser Interstitial Thermal Therapy Seizure Outcome Data," displaying seizure outcomes (Engel & ILAE class) over time (1mo-5y). Engel 1 & ILAE 1 show highest success rates at all time points.

JAMA Neurology @jamaneurology.com · 20d

Editorial: A probabilistic approach to explicate the role of atherosclerotic and arteriolosclerotic CVD would represent the broader clinical-biological construct more accurately. ja.ma/3VTF4Nw

A JAMA Neurology journal page titled Editorial: Limitations of Categorical Diagnoses of CVD-Related Cognitive Impairment by David S. Knopman, MD. Published online September 16, 2025.

JAMA Neurology @jamaneurology.com · 21d

The VasCog-2-WSO criteria provide updated international guidelines for diagnosing vascular cognitive impairment and #dementia, incorporating recent biomarker advancements. ja.ma/4nhczpg

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JAMA Neurology @jamaneurology.com · 21d

Zero-degree head positioning for acute LVO patients is a protective maneuver to maintain clinical stability in the pre-thrombectomy phase while awaiting definitive treatment. ja.ma/3Kbk2r5

Figure 2. Change in Clinical Stability Over Time. Graph A shows patients worsening >=2 points and graph B >=4 points on the NIHSS. Both graphs show the 0° Group and 30° Group over 80 minutes, plotting probability of no neurological deterioration.

JAMA Neurology @jamaneurology.com · 21d

Case report: the appearance of autosomal recessive limb-girdle muscular dystrophy in a 30-year-old man with lower limb weakness, asymmetric atrophy of thigh muscles, and wasting of calf muscles. ja.ma/48f1UXa atabisneuro

Figure 1: Images show a patient with weakness, calf muscle wasting, and asymmetric atrophy of thigh muscles. Image A shows a bulge noted when knees are semiflexed, and Image B shows wasting in thighs in a recumbent position.

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JAMA Neurology @jamaneurology.com · 22d

A 62-year-old man presented with progressive limb weakness and involuntary movements. Take the Clinical Challenge. What is your diagnosis? ja.ma/4mdDmRS

MRI shows axial T1 & T2-weighted images of thighs. Hyperintense lesions, marked by arrowheads, are seen in bilateral thigh muscles, mainly in the posterior compartment. Text: "Axial T1-weighted MRI", "Axial T2-weighted MRI", and figure caption.

JAMA Neurology @jamaneurology.com · 23d

Subthalamic nucleus deep brain stimulation may improve motor function, activities of daily living, and reduces dyskinesia and medication needs in #Parkinson patients. ja.ma/46lMq14

The image shows outcomes at screening up to 5 years post-randomization for Parkinson's Disease. It includes graphs of motor scores, medication usage, patient satisfaction, and quality of life as assessed by PDQ-39 index score.

JAMA Neurology @jamaneurology.com · 24d

Viewpoint: Empowering primary care practitioners to manage common neurological conditions may improve access, reduce delays, and enhance care quality. ja.ma/462qhpJ

An opinion piece titled "Rethinking Neurology and Primary Care Teams—Two Heads Are Better Than One" by Ami Cuneo, Shuvro Roy, Raima M. Amin, and Thabele M. Leslie-Mazwi, discusses integrating PCPs in neurology care.

JAMA Neurology @jamaneurology.com · 24d

Plasma p-tau217 is a useful stand-alone marker and, when combined with confirmatory PET or CSF testing, may enhance precision in identifying cognitively unimpaired individuals with amyloid β pathology for preclinical #Alzheimer disease trials. ja.ma/41P4tvo

Figure 3 shows implications of recruitment strategies for a clinical trial enrolling amyloid beta-positive participants. Six bar graphs compare CSF, PET, plasma, and their combinations, focusing on screening needs, test numbers, and inclusion rates.

JAMA Neurology @jamaneurology.com · 25d

Home high-intensity aerobic training improved ataxia symptoms, fatigue, and aerobic fitness more effectively than dose-matched home balance training among individuals with cerebellar ataxias.

#ANA2025

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JAMA Neurology study on home training for cerebellar ataxias. The study included 33 men and 29 women, with aerobic and balance training interventions. Aerobic cycling showed statistically significant improvements in ataxia symptoms. Graph included.